$100 Cheap flight deals from Santo Domingo (SDQ) to Mayagüez (SJU)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Santo Domingo to Mayagüez
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $100 One Way, $158 Round Trip from Santo Domingo to Mayagüez
Prices starting at $158 for return flights and $100 for one-way flights to Mayagüez were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Mayagüez economy flight packages
Fairmont El San Juan Hotel
Aug 14 - Aug 17
Santo Domingo (SDQ) to San Juan (SJU)
San Juan (SJU) to Santo Domingo (SDQ)
Reviewed on Mar 22, 2026
More About Flying To Mayagüez from Santo Domingo
Route Information for Flights from Santo Domingo to Mayagüez
Origin Airport IATA Code | SDQ |
|---|---|
Destination Airport IATA Code | SJU |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Santo Domingo to Mayagüez
Orbitz On-the-Go is your one-stop shop for discount vacation air travel. Our cutting-edge mobile tools leave you time to pack for the trip. Shop our sales on domestic flights from Santo Domingo to Mayagüez.
Best Bargains Anywhere
Cheap vacations start at Orbitz On-the-Go. Find the best deals on international flights from Santo Domingo to Mayagüez.
Complete Travel Planning
Your phone becomes a full-service vacation travel agency with Orbitz mobile phone apps. From reservations to arrivals, every detail is in the palm of your hand. Book budget flights from Santo Domingo to Mayagüez; add a car and hotel, share your itinerary and keep up with changes. Orbitz apps cover all the bases for you.
Totally Stress-Free
Free Alerts from Orbitz On-the-Go keep your vacation free from worry. Free Alerts updates you the moment any changes occur. You’ll always have the most current flight, gate and baggage claim details. So sit back and enjoy your low fare on Santo Domingo to Mayagüez flights.
More Miles Faster = Maximum Value
Orbitz On-the-Go securely stores your frequent flier and loyalty program information. Watch your miles add up when you book discount Santo Domingo to Mayagüez flights with Orbitz. Make your vacation mileage-friendly with low cost air tickets on Santo Domingo to Mayagüez flights. Orbitz is your destination for vacation value.
- Flights to Mayagüez
- Flights from Santo Domingo
- Santo Domingo Airports
- Mayagüez Airports
- Airlines Operating
Flights from Santo Domingo
- Santo Domingo to New York
- Santo Domingo to Toronto
- Santo Domingo to Orlando
- Santo Domingo to Montreal
- Santo Domingo to Dallas
- Santo Domingo to Madrid
- Santo Domingo to Washington
- Santo Domingo to Chicago
- Santo Domingo to Columbus
- Santo Domingo to San Francisco
- Santo Domingo to Paris
- Santo Domingo to London
- Santo Domingo to Rome
- Santo Domingo to Milan
- Santo Domingo to São Paulo
- Santo Domingo to Atlantic City
- Santo Domingo to Málaga
Santo Domingo Airports
More Destinations
- Hotels near Surf 'N Fun Water Park
- Hotels near Mayagüez Mall
- Hotels near Buye Beach
- Guest Houses in San German
- Historic Hotels in San German
- Pet Friendly Hotels in San German
- San German Hotels
- Las Marias Hotels
- Villas in Las Marias
- Hormigueros Hotels
- Apartments in Cabo Rojo
- Cabin Rentals in Cabo Rojo
- Hotels with Bar in Cabo Rojo
- Pet Friendly Hotels in Cabo Rojo
- Hotels with a Wedding Venue in Cabo Rojo
- Cabo Rojo Hotels
- Vacation Homes in Cabo Rojo
- Rv Parks in Cabo Rojo
- Villas in Cabo Rojo
- Cotuí Hotels
- Aguada Hotels
- Vacation Homes in Aguada
- Villas in Aguada
- Hotels near University of Puerto Rico Mayagüez Campus
- La Mela Hotels
- Mayagüez Pueblo Hotels
- Hotels near Club Deportivo Del Oeste
- Hotels near Eugenio María de Hostos
- Santurce Hotels
- Hotels near La Torre de Piedra
- Stella Hotels
- Vacation Homes in Stella
- Añasco Hotels
- Flights from Barrero
- Flights from San German
- Flights to Cabo Rojo
- Flights from Cabo Rojo
- Flights from Boston to Rincon
- Flights from Charlotte to Rincon
- Flights from Newark to Rincon
- Flights from Tampa to Rincon
- Flights from Nashville to Desecheo Island
- Flights from St. Louis to Desecheo Island
- Flights from Buffalo to Desecheo Island
- Flights from Jacksonville to Desecheo Island
- Flights from Charleston to Desecheo Island
- Flights from Eugenio María de Hostos
- Flights from Kolkata (CCU) to Mayagüez (MAZ)
- Flights from Charlotte (CLT) to Mayagüez (MAZ)
- Flights from Bangkok (DMK) to Mayagüez (MAZ)
- Flights from Panama City (ECP) to Mayagüez (MAZ)
- Flights from Newark Liberty Intl. Airport (EWR) to Mayagüez (MAZ)
- Flights from Yopal (EYP) to Mayagüez (MAZ)
- Flights from Fairbanks (FAI) to Mayagüez (MAZ)
- Flights from Puerto del Rosario (FUE) to Mayagüez (MAZ)
- Flights from La Gomera (GMZ) to Mayagüez (MAZ)
- Flights from Green Bay (GRB) to Mayagüez (MAZ)
- Flights from Klawock (KLW) to Mayagüez (MAZ)
- Flights from Ciudad de Catamayo (LOH) to Mayagüez (MAZ)
- Flights from Lynchburg (LYH) to Mayagüez (MAZ)
- Flights from Harrisburg (MDT) to Mayagüez (MAZ)
- Flights from Manchester (MHT) to Mayagüez (MAZ)
- Flights from Merida (MID) to Mayagüez (MAZ)
- Flights from Montes Claros (MOC) to Mayagüez (MAZ)
- Flights from Madison (MSN) to Mayagüez (MAZ)
- Flights from Sao Paulo de Olivenca (OLC) to Mayagüez (MAZ)
- Flights from Philadelphia (PHL) to Mayagüez (MAZ)
- Flights from Pensacola (PNS) to Mayagüez (MAZ)
- Flights from Reggio di Calabria (REG) to Mayagüez (MAZ)
- Flights from San Angelo (SJT) to Mayagüez (MAZ)
- Flights from Orange County (SNA) to Mayagüez (MAZ)
- Flights from Whangarei (WRE) to Mayagüez (MAZ)
- Flights from Winnipeg (YWG) to Mayagüez (MAZ)
- Flights to Santurce
- Flights from Killeen to Aguadilla
- Flights from Portland to Aguadilla
- Flights from Seattle to Aguadilla
- Flights from Omaha to Aguadilla
- Flights from Pittsburgh to Aguadilla
- Flights from Scranton to Aguadilla
- Flights from Allentown to Aguadilla
- Flights from White Plains to Aguadilla
- Flights from Palm Beach to Aguadilla
- Flights to Añasco
- Flights from Añasco
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.