$51 Cheap flight deals from Orlando (ORL) to Seneca (GSP)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Orlando to Seneca

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 10 - Mon, Oct 20
MCO
Orlando Intl.
GSP
Greenville-Spartanburg Intl.
$198 Roundtrip, found 1 day ago
$198
Roundtrip
found 1 day ago
Select Breeze Airways flight, departing Fri, Oct 10 from Orlando Intl. to Greenville-Spartanburg Intl., returning Mon, Oct 20, priced at $198 found 1 day ago

Airfares from $51 One Way, $101 Round Trip from Orlando to Seneca

Prices starting at $101 for return flights and $51 for one-way flights to Seneca were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Jan 26 - Mon, Feb 2
MCO
Orlando
GSP
Greenville
$101 Roundtrip, found 1 day ago
$101
Roundtrip
found 1 day ago
Select Breeze Airways flight, departing Mon, Jan 26 from Orlando to Greenville, returning Mon, Feb 2, priced at $101 found 1 day ago
Mon, Jan 26 - Mon, Feb 2
MCO
Orlando
GSP
Greenville
$103 Roundtrip, found 18 hours ago
$103
Roundtrip
found 18 hours ago
Select Breeze Airways flight, departing Mon, Jan 26 from Orlando to Greenville, returning Mon, Feb 2, priced at $103 found 18 hours ago
Fri, Jan 16 - Fri, Jan 23
MCO
Orlando
GSP
Greenville
$107 Roundtrip, found 5 days ago
$107
Roundtrip
found 5 days ago
Select Breeze Airways flight, departing Fri, Jan 16 from Orlando to Greenville, returning Fri, Jan 23, priced at $107 found 5 days ago
Fri, Jan 16 - Fri, Jan 23
MCO
Orlando
GSP
Greenville
$113 Roundtrip, found 4 days ago
$113
Roundtrip
found 4 days ago
Select Breeze Airways flight, departing Fri, Jan 16 from Orlando to Greenville, returning Fri, Jan 23, priced at $113 found 4 days ago
Mon, Dec 8 - Thu, Dec 25
MCO
Orlando
GSP
Greenville
$122 Roundtrip, found 1 day ago
$122
Roundtrip
found 1 day ago
Select Breeze Airways flight, departing Mon, Dec 8 from Orlando to Greenville, returning Thu, Dec 25, priced at $122 found 1 day ago

Seneca economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Hartness
4.0-star property

Hotel Hartness

9.8/10 Exceptional! (587 reviews)

Nov 10 - Nov 13

3 night stay

Orlando (MCO) to Greenville (GSP)

Breeze Airways • Coach

Greenville (GSP) to Orlando (MCO)

American Airlines • Coach
Price was $563, price is now $418 per person
$418
per person
found 1 day ago
First of all, LOVE the staff. We get drinks regularly at the hotel bar and the staff is amazing. We decided to stay in the hotel for a special occasion even though we have been loyal local customers since the restaurant and hotel opened. Overall, the experience was ok. The rooms are like a typical Hyatt or Hilton- nothing special. Our biggest issue was with breakfast. It was also ok, but sparse. Waiting for another batch of eggs to be cooked is understandable, but not having the pastries or cups restocked shows a lack of desire when the employee is standing there on her phone. And there must have been 7 employees standing around and snacking on the breakfast items around the time it closed, which is very bad optics. Our biggest issues was that the coffee was moved to the bar after breakfast but the creamer was spoiled. It appeared that it had not been refrigerated and was actually curdled; chunks came into our coffee cups. I think that Hotel Hartness needs to lean less on the architecture and surroundings and more on the little things that make a hotel experience something that is above average.

Reviewed on Mar 18, 2025

Hilton Greenville
3.5-star property

Hilton Greenville

8.2/10 Very Good! (1,015 reviews)

Nov 7 - Nov 14

7 night stay

Orlando (MCO) to Greenville (GSP)

Breeze Airways • Roundtrip • Coach
Save 100% on your flight
Price was $834, price is now $605 per person
$605
per person
found 7 hours ago
This is our go-to hotel for all events at Clemson! Amazing hotel with the greatest staff!

Reviewed on Aug 22, 2025

Holiday Inn Greenville - Woodruff Road by IHG
3.0-star property

Holiday Inn Greenville - Woodruff Road by IHG

8.6/10 Excellent! (636 reviews)

Nov 7 - Nov 14

7 night stay

Orlando (MCO) to Greenville (GSP)

Breeze Airways • Roundtrip • Coach
Price was $728, price is now $543 per person
$543
per person
found 7 hours ago
Clean new hotel, friendly staff. The bathroom was nice and spacious. The beds were comfortable. Breakfast was made to order, priced well. Downtown Greenville is about 15 minutes drive but there are a lot of restaurants near by the hotel. Also Trader Joe’s and Wholefoods are really close.

Reviewed on May 10, 2022

Don't see what you're looking for?
See all available trips from Orlando to Seneca
View all trips

More About Flying To Seneca from Orlando

Route Information for Flights from Orlando to Seneca

Origin Airport IATA Code
ORL
Destination Airport IATA Code
GSP
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Orlando to Seneca

For guaranteed low prices on flights from Orlando to Seneca, search no further than Orbitz. Planning the perfect trip is simple with Orbitz; our range of bargain holiday packages and cutting edge mobile tools makes it quick and easy.

Mobile Movers

Never miss out on bargain prices on Orlando to Seneca flights with free mobile apps for Android and iPhone. On the road? Not a problem – just use m.orbitz.com in your mobile browser to book flights from Orlando to Seneca or check the latest details of your flights.

All-in-One

With Orbitz’s Display Matrix, it is so easy to book your perfect vacation package. Just add in flights from Orlando to Seneca, decide if you want hotels and car rental included and click the button! Orbitz’s Display Matrix clearly shows all the deals and great savings available, including extra discounts, such as free nights.

Cheap Flights Equals Extra Miles

Enjoy great deals on Orlando to Seneca flights and rack up those air miles at the same time! With Orbitz you just add in your frequent flyer number when asked and your qualifying miles are instant. Store your number to your account profile and next time you book your miles will be automatically added.

Safeguard with our Low Price Guarantee

Feel confident when you book your Orlando to Seneca flights, a great hotel or a full vacation package that you are getting the best deal around. Orbitz’s low price guarantee assures you of peace of mind.

More Destinations

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.