$275 Cheap flight deals from Santa Cruz (SRZ) to Santiago (SCL)

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This Weekend's Flight Deals from Santa Cruz to Santiago

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jan 4 - Wed, Jan 28
VVI
Viru Viru Intl.
SCL
Arturo Merino Benitez
$822 Roundtrip, found 3 days ago
$822
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Sun, Jan 4 from Viru Viru Intl. to Arturo Merino Benitez, returning Wed, Jan 28, priced at $822 found 3 days ago

Airfares from $275 One Way, $458 Round Trip from Santa Cruz to Santiago

Prices starting at $458 for return flights and $275 for one-way flights to Santiago were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Apr 4 - Mon, Apr 13
VVI
Santa Cruz
SCL
Santiago
$458 Roundtrip, found 9 hours ago
$458
Roundtrip
found 9 hours ago
Select Boliviana De Aviacion flight, departing Sat, Apr 4 from Santa Cruz to Santiago, returning Mon, Apr 13, priced at $458 found 9 hours ago
Sat, May 2 - Sat, May 9
VVI
Santa Cruz
SCL
Santiago
$465 Roundtrip, found 6 days ago
$465
Roundtrip
found 6 days ago
Select Aerolineas Argentinas flight, departing Sat, May 2 from Santa Cruz to Santiago, returning Sat, May 9, priced at $465 found 6 days ago
Sat, Apr 4 - Mon, Apr 13
VVI
Santa Cruz
SCL
Santiago
$467 Roundtrip, found 9 hours ago
$467
Roundtrip
found 9 hours ago
Select LATAM Airlines Group flight, departing Sat, Apr 4 from Santa Cruz to Santiago, returning Mon, Apr 13, priced at $467 found 9 hours ago
Sat, May 16 - Wed, May 20
VVI
Santa Cruz
SCL
Santiago
$467 Roundtrip, found 5 days ago
$467
Roundtrip
found 5 days ago
Select Boliviana De Aviacion flight, departing Sat, May 16 from Santa Cruz to Santiago, returning Wed, May 20, priced at $467 found 5 days ago
Sat, Apr 4 - Mon, Apr 13
VVI
Santa Cruz
SCL
Santiago
$468 Roundtrip, found 9 hours ago
$468
Roundtrip
found 9 hours ago
Select Aerolineas Argentinas flight, departing Sat, Apr 4 from Santa Cruz to Santiago, returning Mon, Apr 13, priced at $468 found 9 hours ago

Santiago economy flight packages

Price found within the past 48 hours. Click for updated prices.
ICON Hotel
4.0-star property

ICON Hotel

8.6/10 Excellent! (1,000 reviews)

Jan 31 - Feb 2

2 night stay

Santa Cruz (VVI) to Santiago (SCL)

LATAM Airlines Group • Coach

Santiago (SCL) to Santa Cruz (VVI)

Aerolineas Argentinas • Coach
Price was $706, price is now $594 per person
$594
per person
found 1 day ago
The staff are amazing. Mattias at checking was very friendly and helpful. Daniela from rooftop restaurant was very friendly and service very nice.

Reviewed on Apr 20, 2023

Hotel Boutique Castillo Rojo
4.0-star property

Hotel Boutique Castillo Rojo

9.6/10 Exceptional! (635 reviews)

Jan 31 - Feb 2

2 night stay

Santa Cruz (VVI) to Santiago (SCL)

LATAM Airlines Group • Coach

Santiago (SCL) to Santa Cruz (VVI)

Aerolineas Argentinas • Coach
Price was $756, price is now $671 per person
$671
per person
found 1 day ago
A great boutique hotel Wonderful in all respects

Reviewed on Mar 25, 2025

Noi Vitacura
5.0-star property

Noi Vitacura

8.6/10 Excellent! (540 reviews)

Jan 31 - Feb 2

2 night stay

Santa Cruz (VVI) to Santiago (SCL)

LATAM Airlines Group • Coach

Santiago (SCL) to Santa Cruz (VVI)

Aerolineas Argentinas • Coach
Price was $760, price is now $675 per person
$675
per person
found 1 day ago
Great location . Beautiful views . The room with the terrace is big and nice.

Reviewed on Dec 4, 2018

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More About Flying To Santiago from Santa Cruz

Route Information for Flights from Santa Cruz to Santiago

Origin Airport IATA Code
SRZ
Destination Airport IATA Code
SCL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Santa Cruz to Santiago

Great Deals on Flights From Santa Cruz to Santiago

Spend more of your time and money at Santiago instead of sitting at your computer, searching for discount Santa Cruz to Santiago flights. This is why Orbitz makes it easy for you to check out destinations, plan your trip, and book your air fare, hotel, car rental, and more in just one place. Our low price guarantee means that you get great deals on flights from Santa Cruz to Santiago.

Flights That Fit Your Budget

Traveling on a budget? Not to worry if you are using Orbitz. We monitor thousands of fares to make sure we show you the best air ticket prices available for your travel dates. Besides amazing prices on Santa Cruz to Santiago flights, we offer you great deals on hotels, vacation packages, and last-minute getaways for the perfect trip.

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Search for Flights from Santa Cruz to Santiago on the Go

Orbitz offers free mobile apps for iPad, iPhone, and Android-based devices, so even the busiest trip-planner can research and book flights from Santa Cruz to Santiago. Find cheap Santa Cruz to Santiago flights, research local festivities and attractions, and book reservations while sitting in the salon. Orbitz will also update you on flight delays with free alerts sent to your mobile phone or email address, so you’re never left in the dark.

Frequently asked questions

Are there non-stop flights from Santa Cruz to Santiago?
Yep, LATAM Airlines will fly you nonstop from Santa Cruz (VVI-Viru Viru Intl.) to SCL, so you won't have to worry about long layovers or missing that connecting flight.
What is the shortest flight from Santa Cruz to Santiago?
The shortest flight from Viru Viru to Arturo Merino Benitez Airport (SCL) is 3 hours and 39 minutes. Slip a few things into your carry-on to help pass the time, like a fascinating read or a crossword puzzle.
What airlines fly from Santa Cruz to Santiago most frequently?
LATAM Airlines operates the most services from Santa Cruz to Santiago, with 13 monthly flights.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.