Find Southern Indiana Boutique Hotels
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Southern Indiana Boutique Hotels

21c Museum Hotel Louisville
700 W Main Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
$173 nightly
The price is $204 total per night
$204 total
Oct 4 - Oct 5
Total with taxes and fees
Guests staying at 21c Museum Hotel Louisville enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 32 per night, and there's also limo/town car service. The front desk has multilingual staff on hand 24/7 to help with securing valuables, tours or tickets, and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include meeting rooms, conference space, and a 24-hour business center.

Market Street Inn
330 West Market Street Jeffersonville IN
$176 nightly
The price is $199 total per night
$199 total
Sep 9 - Sep 10
Total with taxes and fees
At Market Street Inn, guests have access to a rooftop terrace, free WiFi in public areas, and a terrace. Free parking is included with your stay. Front-desk staff can assist with luggage storage and concierge services. Other amenities at this boutique bed & breakfast include a garden, a picnic area, and a gift shop.
Breakfast included
Parking included

The Brown Hotel
335 W Broadway Louisville KY
$152 nightly
The price is $179 total per night
$179 total
Sep 9 - Sep 10
Total with taxes and fees
The Brown Hotel features a gym, free WiFi in public areas, and meeting rooms. Valet parking is offered for USD 45 per night. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, dry cleaning/laundry, and luggage storage. Other amenities at this luxury hotel include conference space, a 24-hour business center, and free newspapers.
Free WiFi
Restaurant

Embassy Suites Louisville Downtown
501 South Fourth Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
$147 nightly
The price is $173 total per night
$173 total
Oct 4 - Oct 5
Total with taxes and fees
At Embassy Suites Louisville Downtown, guests enjoy features like an indoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is USD 45 per night if you plan to drive, or hop aboard the free airport shuttle (available on request). The front desk is staffed 24/7 to help with tours or tickets, securing valuables, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Galt House Hotel Trademark Collection by Wyndham
140 North Fourth Street Louisville KY
$159 nightly
The price is $187 total per night
$187 total
Sep 9 - Sep 10
Total with taxes and fees
Guests staying at Galt House Hotel Trademark Collection by Wyndham enjoy access to a full-service spa, a gym, and free WiFi in public areas. Valet parking is available for USD 55 per night. Front-desk staff can answer questions 24/7, and assist with tours or tickets, luggage storage, and securing valuables. Other amenities at this spa hotel include conference space, a 24-hour business center, and a seasonal outdoor pool.
Don't see what you're looking for?
See all available properties in Southern Indiana
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southern Indiana hotels essential information
Accommodation | 1,632 hotels |
|---|---|
Lowest Price | $173 |
Highest Price | $204 |
Popular hotels | 21c Museum Hotel Louisville, Market Street Inn, The Brown Hotel, Embassy Suites Louisville Downtown, Galt House Hotel Trademark Collection by Wyndham |
Recent Boutique Hotels Reviews

Derby Hotel & Suites
4/5 Good
"Just became aware of that this was now a separate Hotel from Ramada. It's the same building it's just certain wings on the back side of the hotel. It's an older building but well maintained. The price was ridiculously low. Didn't have access to ramadas inside pool but they had a nice pool outside. Only complaint is that the Wi-Fi signal was terrible and could not connect to it."
A verified traveler stayed at Derby Hotel & Suites
Posted 1 hour ago
More to Explore
- Hotels near Lake Barkley
- Castles in Southeastern Indiana
- Boutique Hotels in Southeastern Indiana
- Casino Resorts & in Southeastern Indiana
- Hotels with Free Parking in Southeastern Indiana
- Hotels with Hot Tubs in Southeastern Indiana
- Hotels with Kitchenettes in Southeastern Indiana
- Oceanfront Hotels in Southeastern Indiana
- Pet Friendly Hotels in Southeastern Indiana
- Ski Resorts & in Southeastern Indiana
- 5 Star Hotels in Ohio River Valley
- B&B in Ohio River Valley
- Cabin Rentals in Ohio River Valley
- Condo Rentals in Ohio River Valley
- Extended Stay Hotels in Ohio River Valley
- Hostels in Ohio River Valley
- Beach Resorts & in Ohio River Valley
- Gay Friendly Hotels in Ohio River Valley
- Golf Resorts & in Ohio River Valley
- Hotels with a Lazy River in Ohio River Valley
- Hotels with Bar in Ohio River Valley
- Hotels with Hot Tubs in Ohio River Valley
- Hotels with Kitchenettes in Ohio River Valley
- Romantic Getaways & Hotels in Ohio River Valley
- Ski Resorts & in Ohio River Valley
- Spa Resorts & in Ohio River Valley
- Ohio River Valley Hotels
- Lodges in Ohio River Valley
- Vacation Homes in Ohio River Valley
- Ranches in Ohio River Valley
- Resorts in Ohio River Valley
- Cabin Rentals in Southwestern Indiana
- Boutique Hotels in Southwestern Indiana
- Golf Resorts & in Southwestern Indiana
- Hotels with Hot Tubs in Southwestern Indiana
- Spa Resorts & in Southwestern Indiana
- Southwestern Indiana Hotels
- Vacation Homes in Southwestern Indiana
- Hotels near Kentucky Lake
- Hotels near Cumberland River
- Flights from Indianapolis to Southeastern Indiana
- Flights from Bangkok to Ohio River Valley
- Flights from London to Ohio River Valley
- Flights from Miami to Ohio River Valley
- Flights from Minneapolis - St. Paul to Ohio River Valley
- Flights from Oklahoma City to Ohio River Valley
- Flights from Ohio River Valley
- Flights to Southwestern Indiana
- Flights from Guayaquil to Southwestern Indiana
- Flights from Charlotte to Southwestern Indiana
- Flights from Minneapolis - St. Paul to Southwestern Indiana
- Flights from Phoenix to Southwestern Indiana
- Flights from Raleigh to Southwestern Indiana
- Flights from Seattle to Southwestern Indiana
- Flights from Paris to Southwestern Indiana
- Flights from Bengaluru to Southwestern Indiana
- Flights from San Salvador to Southwestern Indiana


