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Featured Southern Indiana Boutique Hotels

21c Museum Hotel Louisville
700 W Main Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
$143 nightly
The price is $169 total per night
$169 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Guests staying at 21c Museum Hotel Louisville enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 32 per night, and there's also limo/town car service. The front desk has multilingual staff on hand 24/7 to help with securing valuables, luggage storage, and concierge services. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include meeting rooms, conference space, and a 24-hour business center.
Spa
Pet friendly

Market Street Inn
330 West Market Street Jeffersonville IN
$185 nightly
The price is $209 total per night
$209 total
Dec 24 - Dec 25
Total with taxes and fees
At Market Street Inn, guests have access to a rooftop terrace, free WiFi in public areas, and a terrace. Free parking is included with your stay. Front-desk staff can assist with luggage storage and concierge services. Other amenities at this boutique bed & breakfast include a fireplace in the lobby, a garden, and a picnic area.
Breakfast included
Parking included

The Brown Hotel
335 W Broadway Louisville KY
Free Cancellation
Reserve now, pay when you stay
$168 nightly
The price is $198 total per night
$198 total
Dec 23 - Dec 24
Total with taxes and fees
The Brown Hotel features a gym, free WiFi in public areas, and meeting rooms. Parking is USD 30 per night (USD 36 per night for valet parking)—but if you prefer not to drive, catch a ride in the free airport shuttle (available 24 hours). Multilingual staff at the front desk are standing by 24/7 to help with luggage storage, securing valuables, and concierge services. Other amenities at this luxury hotel include conference space, a 24-hour business center, and free newspapers.
Free airport shuttle
Free WiFi

Embassy Suites Louisville Downtown
501 South Fourth Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
$114 nightly
The price is $134 total per night
$134 total
Dec 29 - Dec 30
Total with taxes and fees
At Embassy Suites Louisville Downtown, guests enjoy features like an indoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is USD 45 per night if you plan to drive, or hop aboard the free airport shuttle (available on request). The front desk is staffed 24/7 to help with securing valuables, luggage storage, and concierge services. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Galt House Hotel Trademark Collection by Wyndham
140 North Fourth Street Louisville KY
Free Cancellation
Reserve now, pay when you stay
$133 nightly
The price is $157 total per night
$157 total
Dec 27 - Dec 28
Total with taxes and fees
Guests staying at Galt House Hotel Trademark Collection by Wyndham enjoy access to a full-service spa, a gym, and free WiFi in public areas. Valet parking is available for USD 55 per night. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, tours or tickets, and luggage storage. Other amenities at this spa hotel include conference space, a 24-hour business center, and a seasonal outdoor pool.
Pool
Spa
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southern Indiana hotels essential information
Accommodation | 1,603 hotels |
|---|---|
Lowest Price | $134 |
Highest Price | $209 |
Popular hotels | 21c Museum Hotel Louisville, Market Street Inn, The Brown Hotel, Embassy Suites Louisville Downtown, Galt House Hotel Trademark Collection by Wyndham |
Recent Boutique Hotels Reviews

Hyatt Place Evansville
5/5 Excellent
"Everything was outstanding! Reason why I'm coming back"
A verified traveler stayed at Hyatt Place Evansville
Posted 2 days ago
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