See all properties

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Hotel in Cape Girardeau with a full-service spa and free breakfast

Choose dates to view prices

Photo gallery for Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Exterior
Indoor pool, open 8 AM to 11 PM, sun loungers
Exterior
Free breakfast
Premium bedding, down comforters, pillowtop beds, in-room safe

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Parking included
  • Free WiFi
  • Air conditioning

Explore the area

View in a map
3253 William Street, Cape Girardeau, MO, 63701
  • Place, Saint Francis Medical Center
    ‪6 min walk‬
  • Place, Southeast Missouri State University
    ‪6 min drive‬
  • Place, Isle Casino Cape Girardeau
    ‪8 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪5 min drive‬

Room options

View all photos for Suite, 2 Queen Beds, Accessible (Roll-In Shower)

Suite, 2 Queen Beds, Accessible (Roll-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Roll-In Shower)

8.0 out of 10
Very good
(6 reviews)
  • 400 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Roll-In Shower)

9.4 out of 10
Exceptional
(6 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed

9.6 out of 10
Exceptional
(32 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 2 Queen Beds

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds

9.6 out of 10
Exceptional
(54 reviews)
  • Sleeps 6
  • 2 Queen Beds

View all photos for Suite, 2 Queen Beds, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Mobility)

9.4 out of 10
Exceptional
(14 reviews)
  • 400 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 Queen Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room, 1 Queen Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 400 sq ft
  • Sleeps 2
  • 1 Queen Bed

View all photos for Standard Room

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room

8.4 out of 10
Very good
(5 reviews)
  • 400 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 Bedroom (Feature)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 Bedroom (Feature)

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 2
  • 1 Queen Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Mobility)

10.0 out of 10
Exceptional
(2 reviews)
  • Sleeps 2
  • 1 King Bed

About the neighborhood

Cape Girardeau

Located within a leisurely stroll of Saint Francis Medical Center, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is within a few miles (5 km) of Saint Francis Healthcare System. This hotel has 102 rooms and welcomes guests with conveniences like free breakfast, a full-service spa, and an indoor pool.

What's nearby

  • Saint Francis Medical Center - 6 min walk - 0.4 miles
  • Southeast Missouri State University - 6 min drive - 3.9 miles
  • Riverfront Park - 6 min drive - 4.8 miles
  • Isle Casino Cape Girardeau - 8 min drive - 5.7 miles
  • Show Me Center - 9 min drive - 5.7 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 10 min drive

Restaurants

  • ‪Chick-fil-A - ‬7 min walk
  • ‪Rhodes - ‬20 min walk
  • ‪McDonald's - ‬10 min walk
  • ‪White Castle - ‬10 min walk
  • ‪Wings Etc. - ‬9 min walk

About this property

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotel in Cape Girardeau with a full-service spa and free breakfast
At Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, guests enjoy a full-service spa, an indoor pool, and a gym. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with dry cleaning/laundry, securing valuables, and luggage storage. Other amenities at this spa hotel include free WiFi in public areas, conference space, and a business center.
52-inch flat-screen TVs come with cable channels, and guests can stay connected with free WiFi and wired Internet. Bathrooms offer hair dryers and free toiletries, and pillowtop beds with premium bedding and pillow menus ensure a restful night. Other amenities include sitting areas, microwaves, and coffee makers.
Recreational amenities at the hotel include an indoor pool and a fitness center.
Guests can indulge in a pampering treatment at the hotel's full-service spa.

Similar properties

Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau
  • Pool
  • Breakfast included
  • Parking included
  • Free WiFi
9.4 out of 10, Exceptional, 143 reviews
$88 nightly
The price is $99
Jan 4 - Jan 5, 2026
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau

Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Free self parking on site
  • Limited onsite self parking
  • Wheelchair-accessible parking available

Food and drink

  • Free breakfast available

Things to do

  • Full-service spa
  • Gym
  • Indoor pool

Family friendly

  • In-room microwave
  • Indoor pool
  • Laundry facilities
  • Mini-fridge

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Vending machine

Guest services

  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop

Business services

  • 118 square feet of conference space
  • Business center
  • Meeting room

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator

More

  • 1 building
  • 4 floors
  • Banquet hall
  • Smoking not allowed

Room amenities

Bedroom

  • Down comforter
  • Pillow menu
  • Pillowtop mattress
  • Premium bedding

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 52-inch flat-screen TV with premium cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Mini-fridge

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Separate sitting area

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: anytime
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property doesn't allow pets

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a smoke detector
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)
  • Check-in: 3:00 PM—-anytime
  • Check-out: 11 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • Onsite safety features include a smoke detector.
  • Cashless payment methods are available for all transactions.
  • This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG).

Additional information about polices, regulations, and more:

  • Pool access available from 8 AM to 11 PM.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • No cribs or infant beds are available.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Holiday Inn Express Cape Girardeau I-55
Holiday Inn Express Hotel Cape Girardeau I-55
Holiday Inn Hotel I-55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Inn Express Cape Girarau I55
Holiday Inn Express Hotel Suites Cape Girardeau I 55
Holiday Inn Express Hotel Suites Cape Girardeau I 55 by IHG

Frequently asked questions

Is a free cancellation option available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG provides free cancellation on some room rates. For more details, review the cancellation policy on our site.

What's there to see close to Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

This hotel is located in Cape Girardeau, close to Show Me Center, Riverfront Bridge Park, and Riverfront Park. You'll also find Mississippi River and Shawnee National Forest within a short drive.

Is parking available on site at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, self parking is offered for free at the hotel. Accessible parking is also available for guests.

Is there a spa available at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

There is a full-service spa at this available for guests to enjoy at this hotel.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG include a casino at the property?

No, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG doesn't have a casino.

Will I find an indoor pool at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Yes, this hotel has an indoor pool. Guests have pool access between 8 AM and 11 PM.

Is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG a good place to stay for couples?

Couples staying at this hotel will appreciate amenities like a pillowtop mattress and free Internet access as well as an indoor pool.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a hot tub?

No, this hotel doesn't have a spa tub.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a restaurant that serves breakfast?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG offers free breakfast though there is no restaurant.

Will Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG allow pets to stay for free?

No, pets aren't allowed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG.

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have connecting rooms?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

How close is the airport from Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

The closest major airport to Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is 6.1 mi away (10 minutes by car). Another top airport is Cairo, IL (CIR-Cairo Regional), which is around 25.5 mi away.

Can I book a room with a balcony at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

No, at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, there aren't any guestrooms that list a balcony.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 780 out of 1000 reviews
Rating 8 - Good. 149 out of 1000 reviews
Rating 6 - Okay. 38 out of 1000 reviews
Rating 4 - Poor. 16 out of 1000 reviews
Rating 2 - Terrible. 17 out of 1000 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.2/10

Amenities

9.6/10

Property conditions & facilities

9.4/10

Eco-friendliness

Reviews

6/10 Okay

Denise

Business traveler, Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Disliked: Staff & service
When I checked in for some reason I had two rooms booked. While talking to the front desk lady she started yelling at me and was very rude. She needs a new job.
Stayed 1 night in Oct 2025

10/10 Excellent

David

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great staff and clean rooms.
Stayed 1 night in Sep 2025

8/10 Good

Mark

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The beds were so uncomfortable and the pillows were worse. I did not sleep well. The breakfast buffet was nice, but the sausage was served cold and it gave us all a stomach ache. The whole hotel was very clean and the staff were all very nice. They even gave me a free tooth rush because I had forgotten mine at home.
Stayed 1 night in Sep 2025

8/10 Good

Douglas

Liked: Cleanliness, staff & service, property conditions & facilities
No shuttle service
Stayed 1 night in Sep 2025

10/10 Excellent

Debra

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Everything was wonderful.
Stayed 2 nights in Jul 2025

10/10 Excellent

Cherish

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We got greeted with such a friendly smile and attitude as soon as we got in. The room was clean and roomy. Would highly recommend and come back.
Stayed 1 night in Sep 2025

10/10 Excellent

Lynn

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

10/10 Excellent

Kelly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was right off the interstate with lots of restaurant options
Stayed 1 night in Sep 2025

8/10 Good

Terri

Stayed 3 nights in May 2025

8/10 Good

David, Caruthersville

Traveled with partner
Liked: Cleanliness, staff & service, amenities
The hotel itself was very warm, along with the room which the thermostat did not work correctly. But no complaints other than that
Stayed 1 night in Sep 2025

10/10 Excellent

Shana

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Darlene Cassidy

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Nice hotel

Great
Stayed 1 night in Sep 2025

10/10 Excellent

Richie

Stayed 1 night in Sep 2025

10/10 Excellent

Douglas

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Sep 2025

10/10 Excellent

Suzanne

Traveled with family
Liked: Staff & service, property conditions & facilities
Everything was good except for our bathroom not being really clean.
Stayed 1 night in Sep 2025

10/10 Excellent

Laura

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Lovely stay

Our stay was wonderful. The rooms are so nice. Bed was comfortable. The jaccuzi tub is excellent. The free breakfast was lovely. Even had healthy options with turkey sausage and egg white omelets. Delicious.
Stayed 1 night in Aug 2025

10/10 Excellent

Christian

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Aug 2025

10/10 Excellent

Carey

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Very Friendly check in Parking lot was very Safe A lot of know restaurants within walking distance from Hotel,Very Clean.
Stayed 2 nights in Aug 2025

10/10 Excellent

Gay

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Felt like I was in a mansion.
Stayed 1 night in Aug 2025

6/10 Okay

Jessica

Stayed 1 night in Aug 2025

8/10 Good

stephanie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Amy Lynn

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was great had a wonderful time with my in-laws.
Stayed 2 nights in Aug 2025

10/10 Excellent

COYT

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Nashon

Stayed 3 nights in Jul 2025

10/10 Excellent

Jessica

Traveled with family
Liked: Amenities
The hotel was very nice and the staff were super helpful. I would stay here again!
Stayed 1 night in Aug 2025

Hotels