Hotels on the Lake in Upstate South Carolina
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Tomorrow night
Check prices in Upstate South Carolina for tomorrow night, Dec 30 - Dec 31Featured Upstate South Carolina Hotels on the Lake

Relax on the shore of Lake Hartwell in our Fair Play retreat
Fair Play SC
Guests staying at this vacation home enjoy a water park, a hot tub, and a computer station. Additional amenities include laundry facilities, a garden, and barbecue grills.
Hot Tub
Kitchen

😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks
Seneca SC
At this vacation home, guests have access to an arcade/game room, laundry facilities, and a garden. This beach vacation home also has barbecue grills.
Pool
Kitchen

Clemson University's James F. Martin Inn
240 Madren Center Drive Clemson SC
Free Cancellation
Reserve now, pay when you stay
$149 nightly
The price is $165 total per night
$165 total
Dec 30 - Dec 31
Total with taxes and fees
Guests staying at Clemson University's James F. Martin Inn enjoy access to a golf course, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with concierge services, securing valuables, and luggage storage. Other amenities at this golf hotel include meeting rooms, a 24-hour business center, and a seasonal outdoor pool.
Pool
Pet friendly

Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street Seneca SC
Free Cancellation
Reserve now, pay when you stay
$121 nightly
The price is $134 total per night
$134 total
Jan 15 - Jan 16, 2026
Total with taxes and fees
Hampton Inn & Suites Seneca-Clemson Area features a 24-hour gym, free WiFi in public areas, and a 24-hour business center. There's free parking if you drive. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Best Western Seneca-Clemson
511 Bypass Highway 123 Seneca SC
Free Cancellation
Reserve now, pay when you stay
$89 nightly
The price is $98 total per night
$98 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests of Best Western Seneca-Clemson enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready. Additional amenities include a computer station, free newspapers, and a vending machine.
Pool
Breakfast included

Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd Seneca SC
Free Cancellation
Reserve now, pay when you stay
$73 nightly
The price is $80 total per night
$80 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests of Days Inn by Wyndham Seneca / Clemson Area enjoy access to free WiFi in public areas, a seasonal outdoor pool, and coffee in a common area. A stay here includes free parking. The 24-hour front desk has staff always at the ready. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Pool
Breakfast included

Fall fun at the cabin! Convenient to Lake Keowee and Clemson
Seneca SC
Guests staying at this cabin enjoy a gym, an arcade/game room, and laundry facilities. Additional amenities include barbecue grills and a garden.
Kitchen
Washer

Hampton Inn Clemson-University Area
851 Tiger Blvd Clemson SC
Free Cancellation
Reserve now, pay when you stay
$110 nightly
The price is $122 total per night
$122 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Hampton Inn Clemson-University Area, guests have access to a gym, free WiFi in public areas, and conference space. There's free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage and dry cleaning/laundry. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and coffee/tea in a common area.
Pool
Breakfast included

Days Inn by Wyndham Clemson
1387 Tiger Blvd Clemson SC
Free Cancellation
Reserve now, pay when you stay
$85 nightly
The price is $94 total per night
$94 total
Dec 30 - Dec 31
Total with taxes and fees
At Days Inn by Wyndham Clemson, guests have access to free WiFi in public areas, a business center, and a computer station. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include free newspapers, a vending machine, and a TV in a common area.
Breakfast included
Parking included

Studio 6 Greenville, SC - I-85 Near Downtown
12 Impact Dr Greenville SC
Free Cancellation
Reserve now, pay when you stay
$57 nightly
The price is $63 total per night
$63 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Studio 6 Greenville, SC - I-85 Near Downtown features free WiFi in public areas, coffee in a common area, and laundry facilities. If you drive, take advantage of free parking. The 24-hour front desk has staff always at the ready. Additional amenities include a vending machine, an ATM, and barbecue grills.
Pet friendly
Parking included

WoodSpring Suites Greenville Central I-85
116 Chalmers Rd Greenville SC
Free Cancellation
Reserve now, pay when you stay
$65 nightly
The price is $71 total per night
$71 total
Dec 30 - Dec 31
Total with taxes and fees
WoodSpring Suites Greenville Central I-85 features free WiFi in public areas, express check-out, and laundry facilities. If you drive, put free parking to good use. Friendly staff can provide front-desk service during limited hours, and also offer advice about sightseeing. This smoke-free hotel also has a vending machine.
Pet friendly
Parking included

Budget Inn Greenville By Hotel O I-85
224 Bruce Rd Greenville SC
Free Cancellation
$58 nightly
The price is $63 total per night
$63 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Guests staying at Budget Inn Greenville By Hotel O I-85 enjoy free WiFi in public areas, laundry facilities, and a vending machine. If you plan to drive, free parking is available. The 24-hour front desk has staff standing by to help with dry cleaning or laundry, and answer any questions about the accommodations.
Pet friendly
Parking included
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Upstate South Carolina hotels essential information
Accommodation | 2,925 hotels |
|---|---|
Lowest Price | $63 |
Highest Price | $165 |
Popular hotels | Relax on the shore of Lake Hartwell in our Fair Play retreat, 😎Anchors Down Lakeside Retreat 15 min to Clemson🏈 Dock, Padle boat, Kayaks, Clemson University's James F. Martin Inn, Hampton Inn & Suites Seneca-Clemson Area, Best Western Seneca-Clemson, Days Inn by Wyndham Seneca / Clemson Area, Fall fun at the cabin! Convenient to Lake Keowee and Clemson, Hampton Inn Clemson-University Area, Days Inn by Wyndham Clemson, Studio 6 Greenville, SC - I-85 Near Downtown, WoodSpring Suites Greenville Central I-85, Budget Inn Greenville By Hotel O I-85 |
Recent Hotels on the Lake Reviews

Hilton Greenville
5/5 Excellent
"Friendly staff, clean room"
A verified traveler stayed at Hilton Greenville
Posted 2 days ago
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