Business Hotels in Lake City, FL
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Featured Lake City Business Hotels

Fairfield Inn & Suites Lake City
538 Sw Corporate Dr Lake City FL
Free Cancellation
Reserve now, pay when you stay
$89 nightly
The price is $100 total per night
$100 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
At Fairfield Inn & Suites Lake City, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The front desk is staffed 24 hours a day to help with dry cleaning/laundry and securing valuables. Additional amenities include a hot tub, a 24-hour business center, and coffee/tea in a common area.
Pool
Hot Tub

Holiday Inn Express & Suites Live Oak by IHG
6694 Us Highway 129 Live Oak FL
Free Cancellation
$121 nightly
The price is $133 total per night
$133 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests staying at Holiday Inn Express & Suites Live Oak by IHG enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Holiday Inn & Suites Lake City by IHG
213 Sw Commerce Dr Lake City FL
Free Cancellation
$95 nightly
The price is $107 total per night
$107 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests staying at Holiday Inn & Suites Lake City by IHG enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Pet friendly

Comfort Suites Lake City
3690 W Us Highway 90 Lake City FL
Free Cancellation
Reserve now, pay when you stay
$107 nightly
The price is $120 total per night
$120 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Guests staying at Comfort Suites Lake City enjoy an outdoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a meeting room, and a computer station.
Pool
Breakfast included

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
Free Cancellation
Reserve now, pay when you stay
$87 nightly
The price is $98 total per night
$98 total
Dec 23 - Dec 24
Total with taxes and fees
At Best Western Plus Lake City, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, take advantage of free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include a 24-hour business center, coffee/tea in a common area, and express check-out.
Pool
Breakfast included

Quality Inn & Suites Live Oak I-10 Exit 283
6819 Us Highway 129 Live Oak FL
Free Cancellation
Reserve now, pay when you stay
$99 nightly
The price is $109 total per night
$109 total
Jan 21 - Jan 22, 2026
Total with taxes and fees
Quality Inn & Suites Live Oak I-10 Exit 283 features an outdoor pool, free WiFi in public areas, and a business center. If you drive, take advantage of free parking. The 24-hour front desk has staff always at the ready. Additional amenities include coffee/tea in a common area, a computer station, and free newspapers.
Pool
Breakfast included

Hampton Inn & Suites Lake City
450 SW Florida Gateway Drive Lake City FL
Free Cancellation
Reserve now, pay when you stay
$114 nightly
The price is $128 total per night
$128 total
Dec 25 - Dec 26
Total with taxes and fees
At Hampton Inn & Suites Lake City, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Baymont by Wyndham Lake City I-75
3598 W Us Highway 90 Lake City FL
Free Cancellation
Reserve now, pay when you stay
$58 nightly
The price is $65 total per night
$65 total
Dec 23 - Dec 24
Total with taxes and fees
Guests of Baymont by Wyndham Lake City I-75 have access to an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub

Home2 Suites by Hilton Lake City
414 Southwest Florida Gateway Boulevard Lake City FL
Free Cancellation
Reserve now, pay when you stay
$122 nightly
The price is $138 total per night
$138 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Home2 Suites by Hilton Lake City, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff standing by 24 hours a day to assist with securing valuables and luggage storage. Additional amenities include a business center, coffee/tea in a common area, and a computer station.
Pool
Breakfast included

Quality Inn Lake City
285 Sw Commerce Dr Lake City FL
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $76 total per night
$76 total
Jan 20 - Jan 21, 2026
Total with taxes and fees
At Quality Inn Lake City, guests enjoy an outdoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Super 8 by Wyndham Lake City
3954 SW State Road 47 Lake City FL
Free Cancellation
Reserve now, pay when you stay
$66 nightly
The price is $75 total per night
$75 total
Dec 24 - Dec 25
Total with taxes and fees
At Super 8 by Wyndham Lake City, guests have access to an outdoor pool, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include coffee/tea in a common area, laundry facilities, and a vending machine.
Pool
Breakfast included

Americas Best Value Inn Lake City
3835 West US Highway 90 Lake City FL
Free Cancellation
Reserve now, pay when you stay
$71 nightly
The price is $80 total per night
$80 total
Dec 23 - Dec 24
Total with taxes and fees
Guests of Americas Best Value Inn Lake City enjoy features like an outdoor pool, free WiFi in public areas, and express check-out. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a picnic area and a vending machine.
Pool
Breakfast included

Days Inn by Wyndham Lake City I-10
3430 N Us Highway 441 Lake City FL
Free Cancellation
Reserve now, pay when you stay
$60 nightly
The price is $68 total per night
$68 total
Dec 23 - Dec 24
Total with taxes and fees
Days Inn by Wyndham Lake City I-10 features an outdoor pool, free WiFi in public areas, and a business center. Free parking is included with your stay. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a computer station, express check-out, and free newspapers.
Pool
Breakfast included

Quality Inn White Springs Suwanee
3119 County Road 136 Live Oak FL
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $75 total per night
$75 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests of Quality Inn White Springs Suwanee enjoy features like an outdoor pool, free WiFi in public areas, and express check-out. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with securing valuables and tours/tickets. Additional amenities include a TV in a common area, a vending machine, and a picnic area.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lake City hotels essential information
Accommodation | 386 hotels |
|---|---|
Lowest Price | $65 |
Highest Price | $138 |
Popular hotels | Fairfield Inn & Suites Lake City, Holiday Inn Express & Suites Live Oak by IHG, Holiday Inn & Suites Lake City by IHG, Comfort Suites Lake City, Best Western Plus Lake City, Quality Inn & Suites Live Oak I-10 Exit 283, Hampton Inn & Suites Lake City, Baymont by Wyndham Lake City I-75, Home2 Suites by Hilton Lake City, Quality Inn Lake City, Super 8 by Wyndham Lake City, Americas Best Value Inn Lake City, Days Inn by Wyndham Lake City I-10, Quality Inn White Springs Suwanee |
Recent Business Hotels Reviews

Tru by Hilton Lake City
5/5 Excellent
"Dese'rae (sp) was lovely. Very helpful, informative and friendly. "
A verified traveler stayed at Tru by Hilton Lake City
Posted 5 hours ago


