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Hilton Jacksonville At Mayo Clinic

4.5 star property

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Photo gallery for Hilton Jacksonville At Mayo Clinic

Breakfast, lunch, dinner served; American cuisine
Lobby
Lobby
Lake view
Terrace/patio

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym
  • Breakfast available

Explore the area

View in a map
4745 Transformation Way, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪1 min walk‬
  • Place, St. Johns Town Center
    ‪8 min drive‬
  • Place, Mayport Naval Station
    ‪17 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪37 min drive‬

Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

8.4 out of 10
Very good
(5 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

9.6 out of 10
Exceptional
(22 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

8.0 out of 10
Very good
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

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About the neighborhood

Jacksonville

Mayo Clinic Florida is a short stroll from Hilton Jacksonville At Mayo Clinic, and other popular attractions like St. Johns Town Center are within a 10-minute drive. This 252-room, 4.5-star hotel has a restaurant, an outdoor pool, and free in-room WiFi.

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 miles
  • University of North Florida - 6 min drive - 5.2 miles
  • St. Johns Town Center - 8 min drive - 7.2 miles
  • TPC Sawgrass - 13 min drive - 9.1 miles
  • Mayport Naval Station - 17 min drive - 11.6 miles

Getting around

  • Jacksonville Station - 28 min drive
  • Jacksonville International Airport (JAX) - 33 min drive

Restaurants

  • ‪Culver’s - ‬3 min drive
  • ‪Starbucks - ‬3 min drive
  • ‪Circle K - ‬16 min walk
  • ‪Starbucks - ‬13 min walk
  • ‪M Brothers at Mayo - ‬14 min walk

About this property

Hilton Jacksonville At Mayo Clinic

Built in 2025, the brand new Hilton Jacksonville At Mayo Clinic offers an outdoor pool, a gym, and free WiFi in public areas. If you drive, self parking is USD 12.00 per night, and there's also a free area shuttle. The 24-hour front desk has staff standing by to help with dry cleaning/laundry, concierge services, and luggage storage. Other amenities at this luxury hotel include meeting rooms, conference space, and express check-out.
Guests can expect to find free WiFi and 55-inch Smart TVs with cable channels and Netflix. Beds sport premium bedding and bathrooms offer hair dryers. Other amenities include coffee makers, free long-distance calls, and free local calls.
Recreational amenities at the hotel include an outdoor pool and a fitness center.

Children under 16 years old are not allowed in the swimming pool without adult supervision. Guests under 21 years old are not allowed in the fitness facility.

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Apr 19 - Apr 20
Total with taxes and fees
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Uncovered self parking on site (USD 12 per night)

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 30 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoking not allowed
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property doesn't allow pets

Children and extra beds

  • Up to 2 kids 18 years old and younger stay free, per registered adult, when using existing bedding
  • Rollaway/extra beds are available for USD 50.00 per night
  • Free cribs/infant beds are available

Property payment types

Important information

Fees

You'll be asked to pay these charges at the property:

  • Breakage deposit: USD 100 per day

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 30 for children
  • Uncovered self parking fee: USD 12.00 per night
  • Rollaway bed fee: USD 50.00 per night

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, and a smoke detector
  • Check-in: 4:00 PM—-5:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day, and checking out is easy with express services. Driving? This property offers parking (fees apply), along with a car charging station.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A credit card for incidental charges and a government-issued photo ID may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards and debit cards. Cash is not accepted. 
  • The credit card used at check-in for incidentals must be in the name of the primary guest who made the reservation.
  • This property reserves the right to pre-authorize the guest's credit card prior to arrival.
  • Onsite safety features include a carbon monoxide detector, a fire extinguisher, and a smoke detector.
  • Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.

Additional information about polices, regulations, and more:

  • Pool access available from 8:00 AM to 10:00 PM.
  • Registered guests are the only ones allowed in guestrooms.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Frequently asked questions

What is there to do within easy reach of Hilton Jacksonville At Mayo Clinic?

This hotel is located in Jacksonville, close to St. Johns Town Center and TPC Sawgrass. You'll also find Windsor Commons Shopping Center and Windsor Parke Golf Club within a short drive.

How much does it cost to stay at Hilton Jacksonville At Mayo Clinic?

As of Apr 7, 2026, prices found for a 1-night stay for 2 adults at Hilton Jacksonville At Mayo Clinic on Apr 18, 2026 start from $204, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is parking available on site at Hilton Jacksonville At Mayo Clinic?

Yes, uncovered parking is offered for USD 12.00 per night. Electric car charging is also available for guests.

Does Hilton Jacksonville At Mayo Clinic feature a casino?

No, Hilton Jacksonville At Mayo Clinic doesn't have a casino.

Will I find an indoor pool at Hilton Jacksonville At Mayo Clinic?

No, this hotel doesn't have an indoor pool; however, there is an outdoor pool. Guests have pool access between 8:00 AM and 10:00 PM.

What amenities will couples enjoy at Hilton Jacksonville At Mayo Clinic?

There are plenty of amenities for couples at this hotel, including an outdoor pool, a bar, and a restaurant.

Does Hilton Jacksonville At Mayo Clinic have a hot tub?

No, there isn't a spa tub at this hotel.

Does Hilton Jacksonville At Mayo Clinic feature a restaurant that includes a breakfast menu?

Yes, Hilton Jacksonville At Mayo Clinic serves buffet breakfast for a surcharge each morning at Coastal Kitchen.

Will Hilton Jacksonville At Mayo Clinic allow pets to stay for free?

No, pets aren't allowed at Hilton Jacksonville At Mayo Clinic.

Does Hilton Jacksonville At Mayo Clinic have connecting rooms?

No, this hotel doesn't feature connecting guestrooms.

How far is the airport from Hilton Jacksonville At Mayo Clinic?

The closest major airport to Hilton Jacksonville At Mayo Clinic is Jacksonville, FL (CRG-Jacksonville Executive at Craig), which is 10.9 mi away (14 minutes by car). Another top airport is Jacksonville International Airport (JAX), which is located 26.9 mi away (33-minute drive).

Can I book a room with a balcony at Hilton Jacksonville At Mayo Clinic?

No, there aren't any guestrooms with balconies at Hilton Jacksonville At Mayo Clinic.

Does Hilton Jacksonville At Mayo Clinic host weddings?

There are wedding services available at Hilton Jacksonville At Mayo Clinic if that's in your vacation plans.

Hilton Jacksonville At Mayo Clinic Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 155 out of 191 reviews
Rating 8 - Good. 17 out of 191 reviews
Rating 6 - Okay. 8 out of 191 reviews
Rating 4 - Poor. 6 out of 191 reviews
Rating 2 - Terrible. 5 out of 191 reviews

9.6/10

Cleanliness

9.8/10

Staff & service

9.4/10

Amenities

10/10

Property conditions & facilities

Reviews

10/10 Excellent

Tyree Alan

Liked: Cleanliness, property conditions & facilities
Very impressed must come back
Stayed 2 nights in Feb 2026

10/10 Excellent

Samuel

Nice room
Stayed 2 nights in Oct 2025

10/10 Excellent

Andrea

Stayed 1 night in Jan 2026

10/10 Excellent

Cassandra

Stayed 4 nights in Dec 2025

10/10 Excellent

Timothy

Stayed 1 night in Dec 2025

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities
Room was spotless, amenities were great, and staff was super nice!
Stayed 5 nights in Dec 2025

10/10 Excellent

Keyante

Business traveler, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful shuttle to Mayo!
Stayed 2 nights in Dec 2025

8/10 Good

Diana

Stayed 4 nights in Dec 2025

10/10 Excellent

Jonelle

Stayed 1 night in Dec 2025

10/10 Excellent

Julio

Stayed 1 night in Dec 2025

10/10 Excellent

Nancy

Traveled with group, Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Just a short overnight stay to attend NYE event. Spent a short time at the very nice bar. Will stay again.
Stayed 1 night in Dec 2025

10/10 Excellent

Catesha

Liked: Cleanliness, amenities, property conditions & facilities
Very clean
Stayed 1 night in Dec 2025

10/10 Excellent

Julie

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, clean, great atmosphere, very nice staff!
Stayed 2 nights in Dec 2025

10/10 Excellent

anjillica

Liked: Cleanliness, amenities, property conditions & facilities
Very nice enjoyed visiting
Stayed 1 night in Dec 2025

8/10 Good

Tristan

Liked: Cleanliness, staff & service, amenities
The staff were courteous, the amenities fantastic. Only problem was a clump of hair from a previous guest found in the shower.
Stayed 1 night in Dec 2025

8/10 Good

Lee

Business traveler
Liked: Cleanliness, staff & service, amenities
Clean room.
Stayed 1 night in Dec 2025

8/10 Good

Gregory

Stayed 5 nights in Nov 2025

10/10 Excellent

Adam

Stayed 7 nights in Dec 2025

10/10 Excellent

Adam

Stayed 1 night in Dec 2025

10/10 Excellent

Kelley

Stayed 1 night in Dec 2025

10/10 Excellent

Robert

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Most everything
Stayed 4 nights in Dec 2025

10/10 Excellent

Ricardo

Stayed 1 night in Dec 2025

10/10 Excellent

Stanislav

Liked: Cleanliness, property conditions & facilities
Cleanliness
Stayed 1 night in Dec 2025

10/10 Excellent

DeAnna

Stayed 2 nights in Nov 2025

10/10 Excellent

Jose

Liked: Cleanliness, staff & service, amenities
Staff was courteous. Room was clean and comfortable. Everything looked brand new. Very clean. Beautiful hotel. Will definitely go back.
Stayed 2 nights in Dec 2025