Business Hotels in Clayton, St. Louis

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Featured Clayton Business Hotels

Don't see what you're looking for?
See all available properties in Clayton
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Clayton hotels essential information

Accommodation
1,762 hotels
Lowest Price
Highest Price
Popular hotels
Clayton Plaza Hotel & Extended Stay, Le Méridien St. Louis Clayton, Hampton Inn & Suites Clayton/St. Louis-Galleria Area, Seven Gables, St. Louis West, a Tribute Portfolio Hotel, The Ritz-Carlton, St. Louis

Recent Business Hotels Reviews