Luxury Hotels in Clayton, St. Louis
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Featured Clayton Luxury Hotels

The Ritz-Carlton, St. Louis
100 Carondelet Plaza, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
The Ritz-Carlton, St. Louis features a gym, free WiFi in public areas, and conference space. Valet parking is available for USD 32 per night. The front desk has multilingual staff on hand 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. Other amenities at this luxury hotel include a business center, express check-in, and express check-out.
Spa
Pet friendly

Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
Guests of Clayton Plaza Hotel & Extended Stay have access to an indoor pool, a 24-hour gym, and a sauna. Self parking is offered for USD 6.00 per day. Front-desk staff can answer questions 24/7, and assist with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include free WiFi in public areas, meeting rooms, and conference space.
Pool
Breakfast included

Le Méridien St. Louis Clayton
7730 Bonhomme Ave, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
At Le Méridien St. Louis Clayton, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is offered for USD 35 per day. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and tours or tickets. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include conference space, a 24-hour business center, and a seasonal outdoor pool.
Pool
Pet friendly

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
26 North Meramec Avenue, St. Louis, MO
Free Cancellation
Reserve now, pay when you stay
Guests of Seven Gables, St. Louis West, a Tribute Portfolio Hotel enjoy free WiFi in public areas, coffee in a common area, and a computer station. Self parking is offered for USD 9.00 per night. The 24-hour front desk has staff standing by to help with securing valuables and concierge services. Other amenities at this boutique hotel include express check-out, free newspapers, and a terrace.
Pet friendly
Free WiFi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Clayton hotels essential information
Accommodation | 1,762 hotels |
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Lowest Price | |
Highest Price | |
Popular hotels | The Ritz-Carlton, St. Louis, Clayton Plaza Hotel & Extended Stay, Le Méridien St. Louis Clayton, Seven Gables, St. Louis West, a Tribute Portfolio Hotel |
Recent Luxury Hotels Reviews

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
5/5 Excellent
Clayton - June 2025
"The hotel was clean and comfortable. The room was very quiet, with no road noise. We would stay here again."
A verified traveler stayed at Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Posted 23 hours ago
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