St. Louis Vacation Homes

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Featured Vacation Homes in St. Louis

Don't see what you're looking for?
See all available properties in St. Louis
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in St. Louis

    Hyatt Regency St. Louis at The Arch

    Hyatt Regency St. Louis at The Arch

    315 Chestnut St St. Louis MO
    $152 nightly
    The price is $179 total per night from Oct 4 to Oct 5
    $179 total
    Oct 4 - Oct 5
    Total with taxes and fees
    8.6/10 Excellent! (4,202 reviews)
    Clayton Plaza Hotel & Extended Stay

    Clayton Plaza Hotel & Extended Stay

    7750 Carondelet Avenue St. Louis MO
    $104 nightly
    The price is $121 total per night from Oct 5 to Oct 6
    $121 total
    Oct 5 - Oct 6
    Total with taxes and fees
    Renaissance St. Louis Airport Hotel

    Renaissance St. Louis Airport Hotel

    9801 Natural Bridge Road St. Louis MO
    $123 nightly
    The price is $144 total per night from Oct 2 to Oct 3
    $144 total
    Oct 2 - Oct 3
    Total with taxes and fees
    8.4/10 Very Good! (1,172 reviews)

St. Louis Vacation Homes

Book vacation homes in St. Louis
Next time you take a group getaway top St. Louis, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of St. Louis vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every St. Louis vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in St. Louis; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a St. Louis rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to St. Louis is sure to be a winner.

St. Louis Vacation Homes essential information

Accommodation
509 Vacation Homes
Lowest Price
$121
Highest Price
$279
Popular accommodation
HotTub-2br2b-near Historic Main Street, Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!, House in Soulard near Busch Stadium, Ballpark Village and Anheuser Busch Brewery, 4bed/3bath House in St. Louis, Pet-Friendly Soulard 2BR – King Bed, Balcony, Fireplace, Free Parking, Centrally located in the Tower Grove East neighborhood!, beautiful small house, Chateau St. Louis ~New~ Historic Home ~ 9min > DT, Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

More to Explore