St. Louis Vacation Homes

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Featured Vacation Homes in St. Louis

Don't see what you're looking for?
See all available properties in St. Louis
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in St. Louis

    Pear Tree Inn St. Louis Near Union Station

    Pear Tree Inn St. Louis Near Union Station

    2211 Market Street St. Louis MO
    $98 nightly
    The price is $115 total per night from Mar 9 to Mar 10
    $115 total
    Mar 9 - Mar 10
    Total with taxes and fees
    8.8/10 Excellent! (1,865 reviews)
    Pear Tree Inn St. Louis Airport

    Pear Tree Inn St. Louis Airport

    10810 Pear Tree Ln St. Ann MO
    $90 nightly
    The price is $106 total per night from Mar 8 to Mar 9
    $106 total
    Mar 8 - Mar 9
    Total with taxes and fees
    9.4/10 Exceptional! (2,852 reviews)
    21C Museum Hotel St Louis

    21C Museum Hotel St Louis

    1528 Locust street St. Louis MO
    $138 nightly
    The price is $162 total per night from Mar 10 to Mar 11
    $162 total
    Mar 10 - Mar 11
    Total with taxes and fees
    9/10 Wonderful! (1,636 reviews)

St. Louis Vacation Homes

Book vacation homes in St. Louis
Next time you take a group getaway top St. Louis, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of St. Louis vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every St. Louis vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in St. Louis; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a St. Louis rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to St. Louis is sure to be a winner.

St. Louis Vacation Homes essential information

Accommodation
531 Vacation Homes
Lowest Price
$106
Highest Price
$268
Popular accommodation
Centrally located in the Tower Grove East neighborhood!, beautiful small house, 4bed/3bath House in St. Louis, St. Charles 1860's Gem - Sleeps 6!, Entire 4BR Home near Lafayette Square, Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!, 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟, Cozy Unit on Historic Main Street , Sweet Escape Near Historic Main Street & MO River

More to Explore