St. Louis Vacation Homes

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Featured Vacation Homes in St. Louis

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in St. Louis

    Hyatt Regency St. Louis at The Arch

    Hyatt Regency St. Louis at The Arch

    315 Chestnut St St. Louis MO
    $127 nightly
    The price is $149 total per night from May 25 to May 26
    $149 total
    May 25 - May 26
    Total with taxes and fees
    8.6/10 Excellent! (4,020 reviews)
    Clayton Plaza Hotel & Extended Stay

    Clayton Plaza Hotel & Extended Stay

    7750 Carondelet Avenue St. Louis MO
    $99 nightly
    The price is $116 total per night from May 10 to May 11
    $116 total
    May 10 - May 11
    Total with taxes and fees
    8.8/10 Excellent! (3,172 reviews)
    Drury Plaza Hotel St. Louis at the Arch

    Drury Plaza Hotel St. Louis at the Arch

    2 South 4th Street St. Louis MO
    $162 nightly
    The price is $189 total per night from May 8 to May 9
    $189 total
    May 8 - May 9
    Total with taxes and fees
    9.4/10 Exceptional! (3,398 reviews)

St. Louis Vacation Homes

Book vacation homes in St. Louis
Next time you take a group getaway top St. Louis, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of St. Louis vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every St. Louis vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in St. Louis; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a St. Louis rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to St. Louis is sure to be a winner.

St. Louis Vacation Homes essential information

Accommodation
560 Vacation Homes
Lowest Price
$116
Highest Price
$272
Popular accommodation
Brand New! Soulard Charmer - Pet Friendly. , 🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟, Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!, Entire 4BR Home near Lafayette Square, Cottage on Historic Main Street- Low Cleaning fee, Cozy, historic South St. Louis bungalow. Right off I-55 making trips 10-20min!, House in Soulard near Busch Stadium, Ballpark Village and Anheuser Busch Brewery, Centrally located in the Tower Grove East neighborhood!, 3-bedroom house in charming St. Louis historic district Free shuttle to games

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