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Featured Vacation Homes in Missouri

Maison Du Lac, Brand New For You With The View! Next to Margaritaville
Maison Du Lac, Brand New For You With The View! Next to Margaritaville
Osage Beach, MO
This vacation home features a water park and barbecue grills.
Beautiful Historic Home Near Downtown With Off-street Parking
Beautiful Historic Home Near Downtown With Off-street Parking
St. Louis, MO
At this vacation home, guests have access to a garden.
Vintage French Beauty - Newly Renovated & Spacious
Vintage French Beauty - Newly Renovated & Spacious
St. Charles, MO
This vacation home is a smoke-free vacation home.
Frog's Hollow Home - 8 Miles to Table Rock Lake!
Frog's Hollow Home - 8 Miles to Table Rock Lake!
Branson, MO
At this vacation home, guests have access to a fitness center, a spa tub, and an outdoor tennis court. This smoke-free vacation home also has barbecue ...
Lakefront Home ~ Miles & Miles Of Lake Views!! Pontoon or Fishing Boat Rental!
Lakefront Home ~ Miles & Miles Of Lake Views!! Pontoon or Fishing Boat Rental!
Camdenton, MO
This vacation home features a water park and barbecue grills.
Secluded, Lakefront Enjoy Nature During Social Distancing!
Secluded, Lakefront Enjoy Nature During Social Distancing!
Kimberling City, MO
$250
At this vacation home, guests have access to features like an arcade/game room. This family-friendly vacation home also has barbecue grills.
Private Luxury Lakefront Lodge-hot Tub~ Huge Pool~theater~close to Branson
Private Luxury Lakefront Lodge-hot Tub~ Huge Pool~theater~close to Branson
Kimberling City, MO
Guests staying at this vacation home enjoy a water park, a spa tub, and an arcade/game room. This family-friendly vacation home also has barbecue grills.
Private Indoor Swimming Pool-game Rooms-walk to Lake-hot Tub-chateau-on-the-cove
Private Indoor Swimming Pool-game Rooms-walk to Lake-hot Tub-chateau-on-the-cove
Branson, MO
Guests staying at this vacation home enjoy an indoor pool, an outdoor pool, and a spa tub. Other amenities at this family-friendly vacation home include an arcade/game ...
Big Cedar Lodge Wilderness Club S101
Big Cedar Lodge Wilderness Club S101
3.0 out of 5.0 1285 Estate Drive, Ridgedale, MO
Guests of this vacation home have access to an outdoor pool, a fitness center, and a spa tub. A stay here includes free parking. Additional amenities include ...
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Missouri Vacation Homes

Book vacation homes in Missouri
Next time you take a group getaway top Missouri, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Missouri vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Missouri vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Missouri; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Missouri rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Missouri is sure to be a winner.

Hotel Options in Missouri

See all 8,164 Properties in Missouri
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.