Business Hotels in Southeast Missouri, MO
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Featured Southeast Missouri Business Hotels

Pear Tree Inn Sikeston
2602 E Malone Avenue, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$80 nightly
The price is $92 total per night
$92 total
Jul 27 - Jul 28
Total includes taxes and fees
Pear Tree Inn Sikeston features an indoor pool, an outdoor pool, and a gym. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include free WiFi in public areas, a hot tub, and a business center.
Pool
Hot Tub

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
$97 nightly
The price is $109 total per night
$109 total
Aug 22 - Aug 23
Total includes taxes and fees
At Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, guests enjoy a full-service spa, an indoor pool, and a gym. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Other amenities at this spa hotel include free WiFi in public areas, conference space, and a business center.
Pool
Breakfast included

Drury Inn & Suites Jackson MO
225 Drury Lane, Jackson, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $95 total per night
$95 total
Jul 29 - Jul 30
Total includes taxes and fees
Guests of Drury Inn & Suites Jackson MO have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$88 nightly
The price is $100 total per night
$100 total
Aug 10 - Aug 11
Total includes taxes and fees
Guests of Best Western Plus Sikeston have access to an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a computer station, and express check-out.
Pool
Breakfast included

Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Jul 31 - Aug 1
Total includes taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Microtel Inn & Suites by Wyndham Sainte Genevieve
21958 Hwy 32, Ste Genevieve, MO
Free Cancellation
Reserve now, pay when you stay
$89 nightly
The price is $100 total per night
$100 total
Aug 14 - Aug 15
Total includes taxes and fees
Guests of Microtel Inn & Suites by Wyndham Sainte Genevieve enjoy access to free WiFi in public areas, meeting rooms, and conference space. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a business center, laundry facilities, and a vending machine.
Breakfast included
Pet friendly

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Jul 27 - Jul 28
Total includes taxes and fees
Guests of Pear Tree Inn Cape Girardeau West enjoy a gym, free WiFi in public areas, and a 24-hour business center. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. This smoke-free hotel also has a TV in a common area.
Breakfast included
Pet friendly

Quality Inn Festus
1200 W Gannon Dr, Festus, MO
At Quality Inn Festus, guests enjoy an indoor pool, a gym, and free WiFi in public areas. There's free parking and a free beach shuttle. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Free Cancellation
Reserve now, pay when you stay
$56 nightly
The price is $64 total per night
$64 total
Aug 12 - Aug 13
Total includes taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Breakfast included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$72 nightly
The price is $82 total per night
$82 total
Jul 27 - Jul 28
Total includes taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a banquet hall.
Breakfast included
Pet friendly

Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr, Sikeston, MO
Free Cancellation
$128 nightly
The price is $145 total per night
$145 total
Aug 17 - Aug 18
Total includes taxes and fees
Guests staying at Holiday Inn Express & Suites Sikeston Southwest by IHG enjoy an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Comfort Inn Festus - St Louis South
1303 Veterans Blvd, Festus, MO
Free Cancellation
Reserve now, pay when you stay
$84 nightly
The price is $95 total per night
$95 total
Aug 24 - Aug 25
Total includes taxes and fees
At Comfort Inn Festus - St Louis South, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, securing valuables, and tours or tickets. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Breakfast included
Parking included

Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd, Jackson, MO
Free Cancellation
Reserve now, pay when you stay
$93 nightly
The price is $101 total per night
$101 total
Jul 27 - Jul 28
Total includes taxes and fees
At Comfort Suites Jackson-Cape Girardeau, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you decide to drive, there's free parking. The front desk is staffed 24 hours a day to help with dry cleaning/laundry and securing valuables. Additional amenities include conference space, a 24-hour business center, and a computer station.
Pool
Breakfast included

Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd, Poplar Bluff, MO
Free Cancellation
$97 nightly
The price is $110 total per night
$110 total
Aug 3 - Aug 4
Total includes taxes and fees
At Holiday Inn Poplar Bluff by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. Additional amenities include meeting rooms, conference space, and a business center.
Pool
Pet friendly

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $103 total per night
$103 total
Aug 14 - Aug 15
Total includes taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included
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See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 587 hotels |
---|---|
Lowest Price | $64 |
Highest Price | $145 |
Popular hotels | Pear Tree Inn Sikeston, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, Drury Inn & Suites Jackson MO, Best Western Plus Sikeston, Drury Inn & Suites Cape Girardeau, Microtel Inn & Suites by Wyndham Sainte Genevieve, Pear Tree Inn Cape Girardeau West, Quality Inn Festus, Baymont Inn and Suites by Wyndham Farmington, MO, Days Inn and Suites by Wyndham Sikeston, Holiday Inn Express & Suites Sikeston Southwest by IHG, Comfort Inn Festus - St Louis South, Comfort Suites Jackson-Cape Girardeau, Holiday Inn Poplar Bluff by IHG, Drury Inn & Suites Sikeston, MO |
Recent Business Hotels Reviews

The Riverview
5/5 Excellent
"This hotel was very clean and super nice. The people were so friendly. I would definitely recommend booking this hotel. It’s beautiful and so so clean. "
A verified traveler stayed at The Riverview
Posted 3 days ago
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