Hotels in Southeast Missouri
Search over 626 hotels from $66
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Top Rated Southeast Missouri Hotels

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
$100 nightly
The price is $113 total per night
$113 total
Mar 29 - Mar 30
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub

The Riverview
777 Main St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
50.35 mi from city center
$95 nightly
The price is $108 total per night
$108 total
Mar 25 - Mar 26
Total with taxes and fees
Guests of The Riverview enjoy features like a casino, free WiFi in public areas, and meeting rooms. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a conference center, a microwave in a common area, and a gift shop.
Parking included
Free WiFi

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
54.11 mi from city center
$94 nightly
The price is $108 total per night
$108 total
Mar 29 - Mar 30
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.73 mi from city center
$91 nightly
The price is $103 total per night
$103 total
Apr 12 - Apr 13
Total with taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
$89 nightly
The price is $96 total per night
$96 total
Mar 29 - Mar 30
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a banquet hall.
Pool
Breakfast included

Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
52.79 mi from city center
$97 nightly
The price is $110 total per night
$110 total
Apr 12 - Apr 13
Total with taxes and fees
At Hampton Inn Sikeston, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
$58 nightly
The price is $66 total per night
$66 total
Mar 30 - Mar 31
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Breakfast included

Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Free Cancellation
Reserve now, pay when you stay
45.36 mi from city center
$80 nightly
The price is $85 total per night
$85 total
Apr 5 - Apr 6
Total with taxes and fees
Guests of Drury Inn & Suites Jackson MO have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
29.15 mi from city center
$73 nightly
The price is $77 total per night
$77 total
Mar 24 - Mar 25
Total with taxes and fees
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included

Silo Farm Haus- located in the heart of wine country!
Ste. Genevieve MO
41.04 mi from city center
$329 nightly
The price is $351 total per night
$351 total
Mar 24 - Mar 25
Total with taxes and fees
At this farm stay, guests have access to features like laundry facilities.
Laundry

The Farmstead Hotel
778 E 3rd St Caruthersville MO
Free Cancellation
Reserve now, pay when you stay
83.3 mi from city center
$92 nightly
The price is $105 total per night
$105 total
Apr 1 - Apr 2
Total with taxes and fees
Guests of The Farmstead Hotel enjoy features like a casino, free WiFi in public areas, and microwave in a common area. A stay here includes free parking. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a TV in a common area and an ATM.
Parking included
Free WiFi

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
Free Cancellation
47.02 mi from city center
$103 nightly
The price is $116 total per night
$116 total
Apr 5 - Apr 6
Total with taxes and fees
At Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG, guests enjoy a full-service spa, an indoor pool, and a gym. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Other amenities at this spa hotel include free WiFi in public areas, conference space, and a business center.
Pool
Breakfast included
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
How much is a Southeast Missouri hotel?
Check Southeast Missouri hotel room prices by star rating

4 Star Hotels
2 properties
Cheap Southeast Missouri hotels options

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$73 nightly
The price is $77 total per night from Mar 24 to Mar 25
$77 total
Mar 24 - Mar 25
Total with taxes and fees
8/10 Very Good! (1,001 reviews)

Super 8 by Wyndham Farmington
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $68 total per night from Mar 30 to Mar 31
$68 total
Mar 30 - Mar 31
Total with taxes and fees
8/10 Very Good! (629 reviews)

Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$82 nightly
The price is $94 total per night from Apr 19 to Apr 20
$94 total
Apr 19 - Apr 20
Total with taxes and fees
5.6/10 (838 reviews)

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Mar 29 to Mar 30
$81 total
Mar 29 - Mar 30
Total with taxes and fees
9/10 Wonderful! (1,001 reviews)

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$58 nightly
The price is $66 total per night from Mar 30 to Mar 31
$66 total
Mar 30 - Mar 31
Total with taxes and fees
8/10 Very Good! (1,004 reviews)

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$68 nightly
The price is $78 total per night from Mar 25 to Mar 26
$78 total
Mar 25 - Mar 26
Total with taxes and fees
7.4/10 Good! (1,001 reviews)
Southeast Missouri hotels essential information
Accommodation | 626 hotels |
|---|---|
Lowest Price | $66 |
Highest Price | $351 |
Popular hotels | Drury Plaza Hotel Cape Girardeau Conference Center, The Riverview, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Hampton Inn Sikeston, Baymont Inn and Suites by Wyndham Farmington, MO, Drury Inn & Suites Jackson MO, Motel 6 Poplar Bluff, MO, Silo Farm Haus- located in the heart of wine country!, The Farmstead Hotel, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG |
Recent Reviews

Hampton Inn Sikeston
5/5 Excellent
"Very nice and helpful staff "
A verified traveler stayed at Hampton Inn Sikeston
Posted 7 hours ago
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