Hotels in Southeast Missouri
Search over 663 hotels from $63
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Top Rated Southeast Missouri Hotels

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
$100 nightly
The price is $113 total per night
$113 total
Jun 14 - Jun 15
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
54.11 mi from city center
$111 nightly
The price is $128 total per night
$128 total
Jun 10 - Jun 11
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
$58 nightly
The price is $63 total per night
$63 total
Jun 21 - Jun 22
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Breakfast included

Candlewood Suites Cape Girardeau by IHG
485 S Mount Auburn Rd Cape Girardeau MO
Free Cancellation
47.19 mi from city center
$75 nightly
The price is $90 total per night
$90 total
Jun 21 - Jun 22
Total with taxes and fees
At Candlewood Suites Cape Girardeau by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you drive, take advantage of free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include meeting rooms, a business center, and free newspapers.
Pool
Pet friendly

The Riverview
777 Main St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
50.35 mi from city center
$121 nightly
The price is $136 total per night
$136 total
Jul 5 - Jul 6
Total with taxes and fees
Guests of The Riverview enjoy features like a casino, free WiFi in public areas, and meeting rooms. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a conference center, a microwave in a common area, and a gift shop.
Parking included
Free WiFi

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
51.43 mi from city center
$141 nightly
The price is $152 total per night
$152 total
Jul 6 - Jul 7
Total with taxes and fees
At Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy, guests have access to features like express check-out. You can put free parking to good use if you drive.
Kitchen
Pet friendly

Drury Inn & Suites Hayti Caruthersville
1317 E Highway 84 Hayti MO
Free Cancellation
Reserve now, pay when you stay
78.5 mi from city center
$98 nightly
The price is $112 total per night
$112 total
Jun 21 - Jun 22
Total with taxes and fees
At Drury Inn & Suites Hayti Caruthersville, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
30.36 mi from city center
$93 nightly
The price is $105 total per night
$105 total
Jul 5 - Jul 6
Total with taxes and fees
Guests of Hampton Inn Poplar Bluff have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Free Cancellation
Reserve now, pay when you stay
45.36 mi from city center
$82 nightly
The price is $87 total per night
$87 total
Jun 21 - Jun 22
Total with taxes and fees
Guests of Drury Inn & Suites Jackson MO have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
1001 Veterans Blvd Festus MO
Free Cancellation
Reserve now, pay when you stay
68.37 mi from city center
$84 nightly
The price is $96 total per night
$96 total
Jun 7 - Jun 8
Total with taxes and fees
Guests of La Quinta Inn & Suites by Wyndham Festus - St. Louis South enjoy a gym, free WiFi in public areas, and a business center. Free parking is available if you drive. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. This smoke-free hotel also has a convenience store.
Breakfast included
Pet friendly

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
$93 nightly
The price is $100 total per night
$100 total
Jun 7 - Jun 8
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a banquet hall.
Pool
Breakfast included

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
29.15 mi from city center
$75 nightly
The price is $84 total per night
$84 total
Jun 9 - Jun 10
Total with taxes and fees
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
How much is a Southeast Missouri hotel?
Check Southeast Missouri hotel room prices by star rating

4 Star Hotels
2 properties
Cheap Southeast Missouri hotels options

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
$75 nightly
The price is $84 total per night from Jun 9 to Jun 10
$84 total
Jun 9 - Jun 10
Total with taxes and fees
8/10 Very Good! (1,000 reviews)

Super 8 by Wyndham Farmington
930 Valley Creek Dr Farmington MO
$60 nightly
The price is $66 total per night from Jun 14 to Jun 15
$66 total
Jun 14 - Jun 15
Total with taxes and fees
8/10 Very Good! (653 reviews)

Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
$75 nightly
The price is $86 total per night from Jun 8 to Jun 9
$86 total
Jun 8 - Jun 9
Total with taxes and fees

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
$72 nightly
The price is $81 total per night from Jun 14 to Jun 15
$81 total
Jun 14 - Jun 15
Total with taxes and fees
9/10 Wonderful! (1,002 reviews)

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$58 nightly
The price is $63 total per night from Jun 21 to Jun 22
$63 total
Jun 21 - Jun 22
Total with taxes and fees
8/10 Very Good! (1,001 reviews)

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
$71 nightly
The price is $81 total per night from Jun 7 to Jun 8
$81 total
Jun 7 - Jun 8
Total with taxes and fees
7.2/10 Good! (1,002 reviews)
Southeast Missouri hotels essential information
Accommodation | 663 hotels |
|---|---|
Lowest Price | $63 |
Highest Price | $152 |
Popular hotels | Drury Plaza Hotel Cape Girardeau Conference Center, Drury Inn & Suites Sikeston, MO, Baymont Inn and Suites by Wyndham Farmington, MO, Candlewood Suites Cape Girardeau by IHG, The Riverview, Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy, Drury Inn & Suites Hayti Caruthersville, Hampton Inn Poplar Bluff, Drury Inn & Suites Jackson MO, La Quinta Inn & Suites by Wyndham Festus - St. Louis South, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Motel 6 Poplar Bluff, MO |
Recent Reviews

Drury Inn & Suites Sikeston, MO
5/5 Excellent
"Clean rooms and was ready when we arrived. We did not use the pool but other guests were enjoying it. Breakfast and Kick back were both great meals."
A verified traveler stayed at Drury Inn & Suites Sikeston, MO
Posted 15 hours ago
More to Explore
- Wappapello Hotels
- Cabin Rentals in Belleview
- Belleview Hotels
- 2 Star Hotels in Central Fredericktown
- Caledonia Hotels
- Cabin Rentals in Piedmont
- Condo Rentals in Piedmont
- Pet Friendly Hotels in Piedmont
- Piedmont Hotels
- Lodges in Piedmont
- Motels in Piedmont
- Lodges in Greenville
- Rv Parks in Greenville
- Resorts in Greenville
- 3 Star Hotels in Ironton
- B&B in Ironton
- Cottages in Ironton
- Cheap Hotels in Ironton
- Historic Hotels in Ironton
- Hotels with Bar in Ironton
- Ironton Hotels
- Motels in Ironton
- Vacation Homes in Ironton
- B&B in Doe Run
- Cabin Rentals in Doe Run
- Cottages in Doe Run
- Hotels near Crown Valley Winery
- Bismarck Hotels
- 3 Star Hotels in Fredericktown
- 5 Star Hotels in Fredericktown
- B&B in Fredericktown
- Cabin Rentals in Fredericktown
- Condo Rentals in Fredericktown
- Cottages in Fredericktown
- Pet Friendly Hotels in Fredericktown
- Fredericktown Hotels
- Motels in Fredericktown
- 3 Star Hotels in Arcadia
- 4 Star Hotels in Arcadia
- Cabin Rentals in Arcadia
- Cottages in Arcadia
- Hotels with Pool in Arcadia
- Motels in Arcadia
- Mill Spring Hotels
- Motels in Mill Spring
- Hotels near Johnson's Shut-ins State Park
- Hotels near Taum Sauk Mountain State Park
- Hotels near Elephant Rocks State Park
- Hotels near Fort Davidson State Historic Site
- Ellington Hotels
- Advance Hotels
- Sturdivant Hotels
- Park Hills Hotels
- Cottages in Middle Brook
- Cobalt Hotels
- Black Hotels
- Farmington Hotels
- Hotels near Twin Oaks Vineyard & Winery
- B&B in Pilot Knob
- Kid Friendly Hotels in Pilot Knob
- Hotels with Pool in Pilot Knob
- Hotels with Air Conditioning in Pilot Knob
- Pilot Knob Hotels
- Hotels near Millstream Gardens Conservation Area
- 4 Star Hotels in Lesterville
- Apartments in Lesterville
- Cabin Rentals in Lesterville
- Cottages in Lesterville
- Kid Friendly Hotels in Lesterville
- Hotels with Pool in Lesterville
- Pet Friendly Hotels in Lesterville
- Lodges in Lesterville
- Vacation Homes in Lesterville
- Hotels near St. Joe State Park
- Hotels near Crown Pointe Golf Club
- Hotels near K Bridge Recreation Area
- Apartments in Arcadia Valley Station
- Cabin Rentals in Arcadia Valley Station
- B&B in Annapolis
- Cabin Rentals in Annapolis
- Vacation Homes in Annapolis
- Hotels near Lake Wappapello
- Centerville Hotels
- Cabin Rentals in Marble Hill
- Marble Hill Hotels
- Motels in Marble Hill
- Des Arc Hotels





