Book 2 Star Hotels in Southeast Missouri
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Southeast Missouri 2 Stars Hotels

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
$54 nightly
The price is $62 total per night
$62 total
Dec 10 - Dec 11
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Breakfast included

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
$90 nightly
The price is $102 total per night
$102 total
Dec 11 - Dec 12
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub

The Riverview
777 Main St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
50.35 mi from city center
$107 nightly
The price is $121 total per night
$121 total
Dec 4 - Dec 5
Total with taxes and fees
Guests of The Riverview enjoy features like a casino, free WiFi in public areas, and meeting rooms. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a conference center, a microwave in a common area, and wedding services.
Parking included
Free WiFi

Baymont by Wyndham Festus
1200 W. Gannon Drive Festus MO
Free Cancellation
Reserve now, pay when you stay
68.15 mi from city center
$77 nightly
The price is $87 total per night
$87 total
Dec 4 - Dec 5
Total with taxes and fees
At Baymont by Wyndham Festus, guests enjoy an indoor pool, a gym, and free WiFi in public areas. There's free parking and a free beach shuttle. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
29.15 mi from city center
$76 nightly
The price is $80 total per night
$80 total
Dec 7 - Dec 8
Total with taxes and fees
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
$84 nightly
The price is $91 total per night
$91 total
Dec 4 - Dec 5
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a vending machine.
Pool
Breakfast included

Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Free Cancellation
Reserve now, pay when you stay
53.02 mi from city center
$95 nightly
The price is $108 total per night
$108 total
Dec 14 - Dec 15
Total with taxes and fees
At Hampton Inn Sikeston, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with securing valuables and luggage storage. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included

Holiday Inn Poplar Bluff by IHG
2781 N Westwood Blvd Poplar Bluff MO
Free Cancellation
30.18 mi from city center
$99 nightly
The price is $112 total per night
$112 total
Dec 7 - Dec 8
Total with taxes and fees
At Holiday Inn Poplar Bluff by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. Additional amenities include meeting rooms, conference space, and a business center.
Pool
Pet friendly

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.79 mi from city center
$70 nightly
The price is $79 total per night
$79 total
Dec 8 - Dec 9
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau West enjoy free WiFi in public areas, a 24-hour business center, and a TV in a common area. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations.
Breakfast included
Pet friendly
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 618 hotels |
|---|---|
Lowest Price | $62 |
Highest Price | $121 |
Popular hotels | Baymont Inn and Suites by Wyndham Farmington, MO, Drury Plaza Hotel Cape Girardeau Conference Center, The Riverview, Baymont by Wyndham Festus, Motel 6 Poplar Bluff, MO, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Hampton Inn Sikeston, Holiday Inn Poplar Bluff by IHG, Pear Tree Inn Cape Girardeau West |
Recent Reviews

Baymont Inn and Suites by Wyndham Farmington, MO
5/5 Excellent
"Was very good stay"
A verified traveler stayed at Baymont Inn and Suites by Wyndham Farmington, MO
Posted 20 hours ago
More to Explore
- Apartments in Arcadia Valley Station
- Cabin Rentals in Arcadia Valley Station
- 4 Star Hotels in Park Hills
- 3 Star Hotels in Flat River
- 5 Star Hotels in Black
- Des Arc Hotels
- 5 Star Hotels in Farmington
- 5 Star Hotels in Mineral Point
- Cottages in Middle Brook
- Cobalt Hotels
- 3 Star Hotels in Van Buren
- 4 Star Hotels in Van Buren
- 5 Star Hotels in Van Buren
- 5 Star Hotels in Fruitland
- Lodges in Greenville
- Rv Parks in Greenville
- Resorts in Greenville
- 3 Star Hotels in Potosi
- Hotels near Taum Sauk Mountain State Park
- Hotels near Elephant Rocks State Park
- 3 Star Hotels in Poplar Bluff
- B&B in Annapolis
- Cabin Rentals in Annapolis
- Vacation Homes in Annapolis
- 5 Star Hotels in Bonne Terre
- 4 Star Hotels in Jackson
- Mill Spring Hotels
- Motels in Mill Spring
- 5 Star Hotels in Desloge
- 5 Star Hotels in Bloomfield
- Hotels near Fort Davidson State Historic Site
- B&B in Pilot Knob
- Kid Friendly Hotels in Pilot Knob
- Hotels with Pool in Pilot Knob
- Hotels with Air Conditioning in Pilot Knob
- Pilot Knob Hotels
- 4 Star Hotels in Lesterville
- Apartments in Lesterville
- Cabin Rentals in Lesterville
- Cottages in Lesterville
- Kid Friendly Hotels in Lesterville
- Hotels with Pool in Lesterville
- Pet Friendly Hotels in Lesterville
- Lodges in Lesterville
- Vacation Homes in Lesterville
- Cabin Rentals in Piedmont
- Condo Rentals in Piedmont
- Pet Friendly Hotels in Piedmont
- Piedmont Hotels
- Lodges in Piedmont
- Motels in Piedmont
- 4 Star Hotels in Perryville
- 5 Star Hotels in Perryville
- 2 Star Hotels in Ozora
- 5 Star Hotels in Ozora
- Hotels near Millstream Gardens Conservation Area
- 2 Star Hotels in Central Fredericktown
- Hotels near K Bridge Recreation Area
- 4 Star Hotels in New Offenburg
- 3 Star Hotels in Arcadia
- 4 Star Hotels in Arcadia
- Cabin Rentals in Arcadia
- Cottages in Arcadia
- Hotels with Pool in Arcadia
- Motels in Arcadia
- 3 Star Hotels in Ironton
- B&B in Ironton
- Cottages in Ironton
- Cheap Hotels in Ironton
- Historic Hotels in Ironton
- Hotels with Bar in Ironton
- Ironton Hotels
- Motels in Ironton
- Vacation Homes in Ironton
- 2 Star Hotels in Longtown
- 3 Star Hotels in Fredericktown
- 5 Star Hotels in Fredericktown
- B&B in Fredericktown
- Cabin Rentals in Fredericktown
- Condo Rentals in Fredericktown
- Cottages in Fredericktown
- Pet Friendly Hotels in Fredericktown
- Fredericktown Hotels
- Motels in Fredericktown
- 4 Star Hotels in Valles Mines
- Cabin Rentals in Marble Hill
- Marble Hill Hotels
- 3 Star Hotels in Ellington


