COVID-19 alert: Travel requirements are changing rapidly, including need for pre-travel COVID-19 testing and quarantine on arrival.

Check restrictions for your trip.Opens in new tab or window

Rochester Vacation Homes

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Featured Vacation Homes in Rochester

RED Cottage Nest2 Bdrm Option4 Miles to Mayo

RED Cottage Nest2 Bdrm Option4 Miles to Mayo

Rochester, MN
The price is $55 per night
This vacation home is a smoke-free vacation home.
St. Augustine at Kutzky Park Mayo Clinic St. Marys Garage Parking!!!

St. Augustine at Kutzky Park Mayo Clinic St. Marys Garage Parking!!!

Rochester, MN
The price is $109 per night
This vacation home is a smoke-free vacation home.
Comfy Room in Centennial Home Near Mayo Clinic

Comfy Room in Centennial Home Near Mayo Clinic

Kasson, MN
Guests staying at this vacation home enjoy features like a water park.
Cozy Room in Historical Home Near Mayo Clinic

Cozy Room in Historical Home Near Mayo Clinic

Kasson, MN
Guests staying at this vacation home enjoy features like a water park.
KABINO: Ideal Mayo Clinic Duplex! Clean! Cozy! See Reviews! 5 Stars! Free WiFi...

KABINO: Ideal Mayo Clinic Duplex! Clean! Cozy! See Reviews! 5 Stars! Free WiFi...

Rochester, MN
This vacation home is a smoke-free vacation home.
Civic Center, River Front, Walk to Mayo Clinic!! Garage Parking!

Civic Center, River Front, Walk to Mayo Clinic!! Garage Parking!

Rochester, MN
The price is $89 per night
This vacation home is a smoke-free vacation home.
Mayo Discount Offered-family-friendly 2 Level-near Mayo

Mayo Discount Offered-family-friendly 2 Level-near Mayo

Rochester, MN
The price is $76 per night
This vacation home is a smoke-free vacation home.
Private Room in Historical Home Near Mayo Clinic

Private Room in Historical Home Near Mayo Clinic

Kasson, MN
Guests staying at this vacation home enjoy features like a water park.
Walk, 1 Block to St. Marys!! St. Augustines Cottage by St. Marys/mayo

Walk, 1 Block to St. Marys!! St. Augustines Cottage by St. Marys/mayo

Rochester, MN
The price is $119 per night
This vacation home is a smoke-free vacation home.
Don't see what you're looking for?
See all available properties in Rochester
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Rochester

    La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

    La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

    4353 Canal Pl SE, Rochester, MN
    The price is $80 per night from May 15 to May 15
    4.2/5Excellent! (36 reviews)
    La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
    Kahler Inn and Suites - Mayo Clinic Area

    Kahler Inn and Suites - Mayo Clinic Area

    9 3rd Ave Nw, Rochester, MN
    The price is $108 per night from May 14 to May 14
    3.7/5Good! (77 reviews)
    Kahler Inn and Suites - Mayo Clinic Area
    Comfort Suites

    Comfort Suites

    4141 Maine Avenue SE, Rochester, MN
    The price is $89 per night from May 10 to May 10
    4.4/5Excellent! (52 reviews)
    Comfort Suites