Panama City Vacation Homes

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Featured Vacation Homes in Panama City

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Panama City

    Hotel Riu Plaza Panama

    Hotel Riu Plaza Panama

    Calle 50, Urb. Marbella Panama City Panama
    $123 nightly
    The price is $135 total per night from Sep 28 to Sep 29
    $135 total
    Sep 28 - Sep 29
    Total with taxes and fees
    Central Hotel Panama Casco Viejo

    Central Hotel Panama Casco Viejo

    Plaza de la Independencia Casco Viejo Panama City Panama
    $183 nightly
    The price is $202 total per night from Oct 2 to Oct 3
    $202 total
    Oct 2 - Oct 3
    Total with taxes and fees
    9/10 Wonderful! (1,003 reviews)
    Megapolis Hotel Panamá

    Megapolis Hotel Panamá

    Avenida Balboa Panama City
    $163 nightly
    The price is $179 total per night from Sep 16 to Sep 17
    $179 total
    Sep 16 - Sep 17
    Total with taxes and fees
    8.4/10 Very Good! (1,699 reviews)

Panama City Vacation Homes

Book vacation homes in Panama City
Next time you take a group getaway top Panama City, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Panama City vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Panama City vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Panama City; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Panama City rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Panama City is sure to be a winner.

Panama City Vacation Homes essential information

Accommodation
54 Vacation Homes
Lowest Price
$135
Highest Price
$658
Popular accommodation
Two Floors Duplex in the middle of Panama City., Downtown Villa with Private Pool & Bar, Luxury 3BR Pool, SPA & Golf Resort Near Canal 303, Luxury 3BR Pool, SPA & Golf Resort Near Canal 302, Unique house with direct access to the beach, four bedrooms, balcony and design, Casa Randa: 6 Ensuite Bedrooms near the Panama Canal, Cozy 3-bedroom townhome with WiFi, AC in fabulous Panamá, 3BR Home in Ancon Hill - Urban Oasis, Sunrise Ocean Views 19th Floor Gorgona Beach