Panama City Vacation Homes

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Featured Vacation Homes in Panama City

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Panama City

    Hotel Riu Plaza Panama

    Hotel Riu Plaza Panama

    Calle 50, Urb. Marbella, Panama City, Panama
    The price is $104 per night from Apr 28 to Apr 29
    $104
    per night
    Apr 28 - Apr 29
    9/10 Wonderful! (2,295 reviews)
    Megapolis Hotel Panamá

    Megapolis Hotel Panamá

    Avenida Balboa, Panama City
    The price is $150 per night from May 12 to May 13
    $150
    per night
    May 12 - May 13
    8/10 Very Good! (377 reviews)
    Decapolis Hotel Panama City

    Decapolis Hotel Panama City

    Avenida Balboa Con Multicentro, Panama City, Panama
    The price is $84 per night from May 6 to May 7
    $84
    per night
    May 6 - May 7
    8.4/10 Very Good! (1,006 reviews)

Panama City Vacation Homes

Book vacation homes in Panama City
Next time you take a group getaway top Panama City, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Panama City vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Panama City vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Panama City; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Panama City rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Panama City is sure to be a winner.

Panama City Vacation Homes essential information

Accommodation
39 Vacation Homes
Lowest Price
$48
Highest Price
$475
Popular accommodation
Oasis with pool near panama canal, Breathtaking Views Mansion w/King Beds, Charming Maison 4Bdr + 4Bth in Historic Center of Casco Viejo, Private Vacation Home: Pool, BBQ and more, Casco Casa Amigos - the only house in Casco, Two Floors Duplex in the middle of Panama City., Apartamento a 10 minutos del aeropuerto, New Apt Great Hosts & Location, Lovely Modern Apartment Two Bedrooms, Two Bathrooms, Nice Location