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Hilton Jacksonville At Mayo Clinic

4.5 star property
Luxury hotel with area shuttle service and a fitness center
VIP Access

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Photo gallery for Hilton Jacksonville At Mayo Clinic

Breakfast, lunch, dinner served; American cuisine
Lobby
Lake view
Terrace/patio
Lobby

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Parking included
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym

Explore the area

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4745 Transformation Way, Jacksonville, FL, 32224
  • Place, Mayo Clinic Florida
    ‪1 min walk‬
  • Place, St. Johns Town Center
    ‪7 min drive‬
  • Place, Mayport Naval Station
    ‪17 min drive‬
  • Airport, Jacksonville, FL (JAX-Jacksonville Intl.)
    ‪32 min drive‬
VIP Access
Curated for quality and service, VIP Access stays consistently receive our highest guest ratings.
  • Expect exceptional service
  • Extra savings and perks for Rewards members
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Room options

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Zero Count)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Zero Count)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

10.0 out of 10
Exceptional
(19 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

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About the neighborhood

Jacksonville

Located within a leisurely stroll of Mayo Clinic Florida, Hilton Jacksonville At Mayo Clinic is within a few miles (5 km) of Harbor City Municipal Golf Course. This 252-room, 4.5-star hotel has a restaurant, an outdoor pool, and free in-room WiFi.

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 miles
  • University of North Florida - 5 min drive - 5.2 miles
  • St. Johns Town Center - 7 min drive - 6.8 miles
  • TPC Sawgrass - 12 min drive - 9.1 miles
  • Mayport Naval Station - 17 min drive - 11.8 miles

Getting around

  • Jacksonville Station - 28 min drive
  • Jacksonville International Airport (JAX) - 33 min drive

Restaurants

  • ‪Culver’s - ‬3 min drive
  • ‪Starbucks - ‬3 min drive
  • ‪M Brothers at Mayo - ‬14 min walk
  • ‪Circle K - ‬16 min walk
  • ‪Starbucks - ‬13 min walk

About this property

Hilton Jacksonville At Mayo Clinic

Luxury hotel with area shuttle service and a fitness center
Built in 2025, the brand new Hilton Jacksonville At Mayo Clinic offers an outdoor pool, a gym, and free WiFi in public areas. There's free parking and a free area shuttle. The 24-hour front desk has staff standing by to help with luggage storage, dry cleaning/laundry, and concierge services. Other amenities at this luxury hotel include meeting rooms, conference space, and express check-out.
Guests can expect to find free WiFi and 55-inch Smart TVs with cable channels and Netflix. Beds sport premium bedding and bathrooms offer hair dryers. Other amenities include coffee makers, free long-distance calls, and free local calls.
Recreational amenities at the hotel include an outdoor pool and a fitness center.

Children under 16 years old are not allowed in the swimming pool without adult supervision. Guests under 16 years old are not allowed in the fitness facility.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Free uncovered self parking on site

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoking not allowed
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property doesn't allow pets

Children and extra beds

  • Up to 2 kids 18 years old and younger stay free, per registered adult, when using existing bedding
  • Rollaway/extra beds are available for USD 50.00 per night
  • Free cribs/infant beds are available

Property payment types

Important information

Fees

You'll be asked to pay these charges at the property:

  • Breakage deposit: USD 100 per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 21 for children
  • Rollaway bed fee: USD 50.00 per night

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector and a smoke detector
  • Check-in: 4:00 PM—-5:00 AM
  • Check-out: 11:00 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day, and checking out is easy with express services. Driving? This property offers free parking, along with a car charging station.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A credit card for incidental charges and a government-issued photo ID may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards and debit cards. Cash is not accepted. 
  • The credit card used at check-in for incidentals must be in the name of the primary guest who made the reservation.
  • This property reserves the right to pre-authorize the guest's credit card prior to arrival.
  • Onsite safety features include a carbon monoxide detector and a smoke detector.
  • Cashless payment methods are available for all transactions and guests can access their rooms with a mobile device.

Additional information about polices, regulations, and more:

  • Pool access available from 8:00 AM to 10:00 PM.
  • Registered guests are the only ones allowed in guestrooms.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Frequently asked questions

What is there to do within easy reach of Hilton Jacksonville At Mayo Clinic?

This hotel is located in Jacksonville, close to St. Johns Town Center and TPC Sawgrass. You'll also find Adventure Landing and Windsor Commons Shopping Center within a short drive.

Is parking available on site at Hilton Jacksonville At Mayo Clinic?

Yes, uncovered self parking is offered for free at the hotel. Electric car charging is also available for guests.

Does Hilton Jacksonville At Mayo Clinic feature a casino?

No, Hilton Jacksonville At Mayo Clinic doesn't have a casino.

Will I find an indoor pool at Hilton Jacksonville At Mayo Clinic?

No, this hotel doesn't have an indoor pool; however, there is an outdoor pool. Guests have pool access between 8:00 AM and 10:00 PM.

What will couples enjoy most about a stay at Hilton Jacksonville At Mayo Clinic?

There are plenty of amenities for couples at this hotel, including an outdoor pool, a bar, and a restaurant.

Does Hilton Jacksonville At Mayo Clinic have a hot tub?

No, there isn't a spa tub at this hotel.

Does Hilton Jacksonville At Mayo Clinic feature a restaurant that includes a breakfast menu?

Yes, Hilton Jacksonville At Mayo Clinic serves buffet breakfast for a surcharge each morning at Coastal Kitchen.

Will Hilton Jacksonville At Mayo Clinic allow pets to stay for free?

No, pets aren't allowed at Hilton Jacksonville At Mayo Clinic.

Are there connecting rooms at Hilton Jacksonville At Mayo Clinic?

No, this hotel doesn't feature connecting guestrooms.

How far is the airport from Hilton Jacksonville At Mayo Clinic?

The closest major airport to Hilton Jacksonville At Mayo Clinic is Jacksonville, FL (CRG-Jacksonville Executive at Craig), which is 10.9 mi away (14 minutes by car). Another top airport is Jacksonville International Airport (JAX), which is located 26.9 mi away (33-minute drive).

Can I book a room with a balcony at Hilton Jacksonville At Mayo Clinic?

No, there aren't any guestrooms with balconies at Hilton Jacksonville At Mayo Clinic.

Does Hilton Jacksonville At Mayo Clinic host weddings?

There are wedding services available at Hilton Jacksonville At Mayo Clinic if that's in your vacation plans.

Hilton Jacksonville At Mayo Clinic Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 99 out of 118 reviews
Rating 8 - Good. 9 out of 118 reviews
Rating 6 - Okay. 4 out of 118 reviews
Rating 4 - Poor. 3 out of 118 reviews
Rating 2 - Terrible. 3 out of 118 reviews

10/10

Cleanliness

9.8/10

Staff & service

9.6/10

Amenities

10/10

Property conditions & facilities

Reviews

10/10 Excellent

Nancy

Traveled with group, Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Just a short overnight stay to attend NYE event. Spent a short time at the very nice bar. Will stay again.
Stayed 1 night in Dec 2025

10/10 Excellent

Adam

Stayed 1 night in Dec 2025

10/10 Excellent

Donald

Stayed 2 nights in Dec 2025

10/10 Excellent

Marc

Business traveler
Liked: Cleanliness, amenities, property conditions & facilities
The hotel is brand new. The design, finishes, and colors are well chosen. The hotel is on the Mayo campus, and the Mayo shuttle comes every 15 minutes. The restaurant located at the hotel was fantastic, the food was delicious and well prepared. All the employees at the hotel were very polite, helpful, and obviously invested in making that Hilton stand out. I really enjoyed my stay there.
Stayed 1 night in Dec 2025

6/10 Okay

Gisela

Stayed 7 nights in Oct 2025

10/10 Excellent

Albert

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff and rooms
Stayed 1 night in Oct 2025

10/10 Excellent

gurpreet

Liked: Cleanliness
Great location
Stayed 1 night in Oct 2025

10/10 Excellent

Maria

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities
Muy moderno y bonito el hotel
Stayed 3 nights in Oct 2025