$135 Cheap flights to Santa Cruz

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Top places to visit in Santa Cruz

Cheap flights to Santa Cruz from $135 One Way, $262 Round Trip

$262 return flights and $135 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

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Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
GYEPuerto Baquerizo MorenoNovember 15 to November 22$270
UIOPuerto Baquerizo MorenoNovember 14 to November 21$337
UIOSanta RosaNovember 13 to November 20$338
GYESanta RosaNovember 13 to November 22$372
JFKSanta RosaNovember 13 to November 19$744
MIASanta RosaNovember 15 to November 23$837
JFKPuerto Baquerizo MorenoNovember 15 to November 22$898
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
$145 nightly
The price is $145 total per night from Dec 11 to Dec 12
$145 total
Dec 11 - Dec 12
Stay at this hotel in Puerto Ayora. Enjoy free WiFi, 3 hot tubs, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Las ...
Opens in a new windowHotel Fiesta
El Barranco Galapagos

El Barranco Galapagos

2.5 out of 5
Los colonos Puerto Ayora Galapagos
$245 nightly
The price is $245 total per night from Nov 15 to Nov 16
$245 total
Nov 15 - Nov 16
Stay at this hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and room service. Popular attractions Malecon and Gus Angermeyer Ferry Terminal are located ...
Opens in a new windowEl Barranco Galapagos
Finch Bay Galapagos Hotel

Finch Bay Galapagos Hotel

4.5 out of 5
Barrio Punta Estrada Puerto Ayora Galapagos
$541 nightly
The price is $596 total per night from Nov 15 to Nov 16
$596 total
Nov 15 - Nov 16
Book a stay at this luxury hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and a full-service spa. Popular attractions Playa de los Alemanes and Malecon ...
9.4/10 Exceptional! (105 reviews)
"המלון הכי טוב בגלאפגוס רמה גבוהה מאוד שירות מדהים קצת יקר אבל שווה את המחיר מומלץ מאוד"

Reviewed on Oct 14, 2026

Opens in a new windowFinch Bay Galapagos Hotel
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Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
$125 nightly
The price is $125 total per night from Nov 19 to Nov 20
$125 total
Nov 19 - Nov 20
Book a stay at this family-friendly hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the breakfast and the helpful ...
10/10 Exceptional! (173 reviews)
"Very good stay. Property clean, well maintainrd, staff very helpful even helping us arrange a trip and taxi to airport. Water in room was a great touch and not something we had had in Galapagos before here"

Reviewed on Oct 30, 2026

Opens in a new windowMaidith Galapagos Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Santa Cruz

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.