$135 Cheap flights to Santa Cruz
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Top places to visit in Santa Cruz
Cheap flights to Santa Cruz from $135 One Way, $270 Round Trip
$270 return flights and $135 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Deals For This Weekend's Flights
| Origin | Destination | Travel Dates | Flights From* |
|---|---|---|---|
| GYE | Puerto Baquerizo Moreno | November 7 to November 14 | $285 |
| UIO | Puerto Baquerizo Moreno | November 6 to November 9 | $299 |
| GYE | Santa Rosa | November 6 to November 7 | $325 |
| UIO | Santa Rosa | November 6 to November 11 | $331 |
| JFK | Puerto Baquerizo Moreno | November 6 to November 13 | $726 |
| JFK | Santa Rosa | November 6 to November 13 | $759 |
| MIA | Puerto Baquerizo Moreno | November 7 to November 11 | $777 |
| LAX | Santa Rosa | November 6 to November 11 | $1,279 |
| LAX | Puerto Baquerizo Moreno | November 6 to November 11 | $1,589 |
Find The Perfect Hotel For After Your Flight
Score Epic Santa Cruz Accommodation Deals
Hotel Fiesta
"Love the place, cozy and very clean!"
Reviewed on Oct 28, 2026
Maidith Galapagos Inn
"Very good stay. Property clean, well maintainrd, staff very helpful even helping us arrange a trip and taxi to airport. Water in room was a great touch and not something we had had in Galapagos before here"
Reviewed on Oct 30, 2026
El Barranco Galapagos
Hotel el descanso del Guia
Need a Car For After Your Flight?
Economy
Compact
Midsize
SUV
Santa Cruz
Finding cheap flights to Santa Cruz is easy when you have Orbitz at your fingertips. Not only does Orbitz offer great deals on Santa Cruz flights, but we also include some special extras to make booking a breeze. Just check out our:
Mobile Site and Apps
With Orbitz’s mobile site, m.orbitz.com, you can book your flights to Santa Cruz through your smartphone or tablet’s Web browser. Plus, our free downloadable apps for Android and iPhone mean it’s just a simple click to access your flight updates and alerts. You can even book exclusive mobile-only deals on hotels to go with your flights to Santa Cruz—even on the same day.
Pick and Choose or Book Full Vacation Packages
Don’t just be satisfied with great deals on Santa Cruz flights—go for the full package! With Orbitz, you can also find fantastic savings on the perfect hotel, car rental, cruise, and even activities, so you don’t waste your trip waiting in line but have the time to enjoy your trip. Pick and choose the add-ons you need, or book an entire vacation package for greater overall discounts.
Rewards That Are Miles Better
Booking directly with an airline earns you air miles or points, and you can get those same rewards with booking on Orbitz too. When you book qualifying flights to Santa Cruz with Orbitz, just add in your frequent flyer number during your online booking and your details will be sent to your program.
Great Deals Every Day
Add in our extra savings on packages, free nights, and other discounts, and you know you are in good hands.
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.