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Due to coronavirus (COVID-19) travel advisories, some destinations may be unavailable for certain dates. Find out more.
Due to coronavirus (COVID-19) travel advisories, some destinations may be unavailable for certain dates. Find out more.
Book a package and join the 188 others who’ve received 100% off their flights this year!
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Book a package and join the 188 others who’ve received 100% off their flights this year!


Cayo Santa Maria Vacation Package Deals

If you're hoping to combine your hotel and flight options to make your dollar go further, you're where you need to be! Just kick back, take it easy and let the specialist team at Orbitz help you create the ultimate Cayo Santa Maria vacation.

Do you want to save up to $369^? All you've got to do is combine your bookings by selecting your choice of airfares, hotels, rental cars and experiences.

You've got no less than 500,000 accommodations across the globe and 500 airlines to mix and match from. With such a wide range, crafting your ideal vacation is no problem.

There are endless available options to suit you and your traveling style. All you have to do is pick your package and get set for an extraordinary getaway.

Cayo Santa Maria Travel Guide

Where is Cayo Santa Maria?

The excitement's bubbling inside. You're just about to book your ticket. But hold on — you don't have the remotest idea where Cayo Santa Maria is! Let us point you in the right direction.

It's situated in Cuba, 4 miles away from Cayo Ensenachos.

Places to Visit in Cayo Santa Maria

Cayo Los Brujas is just over the water and offers visitors a range of cool things to do. After some more ideas? A trip to Cayo Santa Maria Dolphinarium is a great day out for you and your entire group. Everyone will surely enjoy meeting some of the most adorable marine animals on the planet — dolphins!

Car Rentals in Cayo Santa Maria

Hey there, globetrotter. We know you're eager to make the most of your escape, so why not take a look at car rentals in Cayo Santa Maria? Book through Orbitz and get your epic adventure on the road today!

Nearest Airports to Cayo Santa Maria

Lying 45 miles to the south of Cayo Santa Maria's downtown area, Maximo Gomez Airport (AVI) is where your trip begins. Once you've collected your luggage from baggage claim, you'll be admiring the awesome sights of Cayo Santa Maria soon enough!

Popular Places to Visit Near Cayo Santa Maria

If you have a spare day and don't mind traveling 35 miles, head on over to Caibarien. This nearby area is teeming with things to see and do. Caibarien Beach should be a priority. San Juan Bautista de Remedios Museum and the Galería del Arte Carlos Enríquez are worthwhile attractions too. Situated 55 miles away, Sancti Spiritus is another neighboring destination. If you visit, make sure you get to Serafn Sanchez Square, Iglesia Parroquial Mayor and the Museo Provincial.

Join Orbitz Rewards

We know... rewards programs are a dime a dozen. But what would life be like without those little perks and dollar savings? We've invented a simple program that'll reward you quicker than anyone else. To get instant Orbucks, just book with us!

Perks, like complimentary breakfast and Wi-Fi, at Orbitz Rewards VIP Hotels are available to every gold and platinum member. Like the sound of that? Just stay four nights for gold status and 12 nights for platinum status in a full year. And, how do you redeem Orbucks? You can use your Orbitz Rewards points on your following booking — it really is that simple!

No Cancellation Fees

Whipped out your passport, made your booking but now you can't go? Don't worry — we make canceling your plans simple and straightforward by having a no-fee policy.^ Act promptly and your chosen hotel and airline might do the same!

Top Rated Hotels for your Cayo Santa Maria Vacation

Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive
Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive
3.5 out of 5.0 Cayo Santa Maria, Cayo Santa Maria, Villa Clara
$187
4.0/5 (1 reviews)

The pool as the view at the balcony. Very impressive

Reviewed on Aug 12, 2019
Guests staying at Sanctuary at Grand Memories Santa Maria - Adults Only - All Inclusive enjoy an outdoor pool, a health club, and outdoor tennis courts. A stay ...

^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from January 1, 2019 to December 31, 2019 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.