Cheap flights from ORD to TMS (O'Hare Intl. to São Tomé Intl.)

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Cheap Flights from ORD to TMS starting at $1,138 One Way, $1,777 Round Trip

Prices starting at $1,777 for return flights and $1,138 for one-way flights to São Tomé Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Feb 3 - Sat, Feb 13
ORD
Chicago
TMS
São Tomé Island
$1,777 Roundtrip, found 6 days ago
$1,777
Roundtrip
found 6 days ago
Select Air Canada flight, departing Wed, Feb 3 from Chicago to São Tomé Island, returning Sat, Feb 13, priced at $1,777 found 6 days ago
Wed, Feb 3 - Sat, Feb 13
ORD
Chicago
TMS
São Tomé Island
$1,782 Roundtrip, found 6 days ago
$1,782
Roundtrip
found 6 days ago
Select Swiss International Air Lines flight, departing Wed, Feb 3 from Chicago to São Tomé Island, returning Sat, Feb 13, priced at $1,782 found 6 days ago
Wed, Feb 3 - Sat, Feb 13
ORD
Chicago
TMS
São Tomé Island
$1,785 Roundtrip, found 6 days ago
$1,785
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Wed, Feb 3 from Chicago to São Tomé Island, returning Sat, Feb 13, priced at $1,785 found 6 days ago
Wed, Feb 3 - Sat, Feb 13
ORD
Chicago
TMS
São Tomé Island
$1,789 Roundtrip, found 6 days ago
$1,789
Roundtrip
found 6 days ago
Select Swiss International Air Lines flight, departing Wed, Feb 3 from Chicago to São Tomé Island, returning Sat, Feb 13, priced at $1,789 found 6 days ago
Wed, Feb 3 - Sat, Feb 13
ORD
Chicago
TMS
São Tomé Island
$1,792 Roundtrip, found 6 days ago
$1,792
Roundtrip
found 6 days ago
Select Lufthansa flight, departing Wed, Feb 3 from Chicago to São Tomé Island, returning Sat, Feb 13, priced at $1,792 found 6 days ago

Hotel Ideas near São Tomé Intl.

Airport Hotels near São Tomé Intl.

Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection

4 out of 5
Praia Lagarto São Tomé
$184 nightly
The price is $215 total per night from Jun 19 to Jun 20
$215 total
Jun 19 - Jun 20
Total with taxes and fees
Book a stay at this beach resort in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon Téla Chocolate ...
Omali São Tomé – Principe Collection
Praia Accommodation

Praia Accommodation

3 out of 5
Praia Lagarto São Tomé São Tomé
$110 nightly
The price is $127 total per night from Jun 9 to Jun 10
$127 total
Jun 9 - Jun 10
Total with taxes and fees
Book a stay at this beach B&B in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon Téla Chocolate ...
7.4/10 Good! (19 reviews)
"Great place to stay"

Reviewed on Nov 21, 2024

Praia Accommodation
Hotel Praia

Hotel Praia

3.5 out of 5
Praia Lagarto - Cx. Postal 61 São Tomé
$156 nightly
The price is $181 total per night from Jun 12 to Jun 13
$181 total
Jun 12 - Jun 13
Total with taxes and fees
Book a stay at this business-friendly hotel in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon ...
Hotel Praia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In São Tomé Island

Pestana São Tomé

Pestana São Tomé

5 out of 5
Avenida Marginal 12 De Julho São Tomé
$228 nightly
The price is $263 total per night from Jun 9 to Jun 10
$263 total
Jun 9 - Jun 10
Total with taxes and fees
Book a stay at this luxury hotel in São Tomé. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Estadio Nacional 12 de Julho and Cloçon ...
Pestana São Tomé
Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection

4 out of 5
Praia Lagarto São Tomé
$184 nightly
The price is $215 total per night from Jun 19 to Jun 20
$215 total
Jun 19 - Jun 20
Total with taxes and fees
Book a stay at this beach resort in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon Téla Chocolate ...
Omali São Tomé – Principe Collection
Porcelana Hotel

Porcelana Hotel

3 out of 5
Ponte Tavares - Fruta fruta São Tomé Água Grande
$40 nightly
The price is $46 total per night from Jun 21 to Jun 22
$46 total
Jun 21 - Jun 22
Total with taxes and fees
Stay at this B&B in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cloçon Téla Chocolate Factory and Estadio Nacional 12 de ...
9.4/10 Exceptional! (12 reviews)
"Lovely hotel in a great location to the centre with nice rooms and great breakfast. However, Sao Tome has frequent power cuts and the hotel does not have a generator which means you could be out hours or even without any electricity or internet. This isn't great for paying guests."

Reviewed on Apr 15, 2026

Porcelana Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

ORD to TMS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
ORD Address & GPS
Address:
10000 West O'Hare
Chicago IL, 60666
United States
IATA Code:
ORD
Longitude:
-87.904876
Latitude:
41.976912
Time Zone:
America/Chicago
TMS Address & GPS
Address:
Sao Tome Island ,
Sao Tome and Principe
IATA Code:
TMS
Longitude:
6.725
Latitude:
0.378333
Time Zone:
Africa/Sao_Tome

Frequently asked questions

What is the shortest flight from O'Hare Airport to TMS?
Choose your favorite seat, because you'll be sitting in it for quite some time on your Chicago to São Tomé Island journey. The fastest possible flight time from O'Hare Airport to Sao Tome Intl. Airport (TMS) is 14 hours and 25 minutes.
How many hours flight from O'Hare Intl. Airport (ORD) to Sao Tome Intl. Airport?
With a flight time of around 14 hours and 25 minutes, traveling from ORD to TMS is no short trip. Get set for some long hours in the sky and think about using your air miles to upgrade.
What airlines have the most flights from O'Hare Airport to Sao Tome Intl. Airport?
Currently, there are no airlines that advertise direct flights between O'Hare Airport and Sao Tome Intl. Airport. But never fear. There are plenty of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.