Cheap flights from ORD to TMS (O'Hare Intl. to São Tomé Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from ORD to TMS starting at $1,152 One Way, $2,040 Round Trip

Prices starting at $2,040 for return flights and $1,152 for one-way flights to São Tomé Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Apr 4 - Wed, Apr 8
ORD
Chicago
TMS
São Tomé Island
$2,040 Roundtrip, found 4 days ago
$2,040
Roundtrip
found 4 days ago
Select TAP Portugal flight, departing Sat, Apr 4 from Chicago to São Tomé Island, returning Wed, Apr 8, priced at $2,040 found 4 days ago
Sat, Apr 4 - Wed, Apr 8
ORD
Chicago
TMS
São Tomé Island
$2,051 Roundtrip, found 4 days ago
$2,051
Roundtrip
found 4 days ago
Select TAP Portugal flight, departing Sat, Apr 4 from Chicago to São Tomé Island, returning Wed, Apr 8, priced at $2,051 found 4 days ago
Wed, Apr 29 - Sun, May 3
ORD
Chicago
TMS
São Tomé Island
$2,095 Roundtrip, found 10 hours ago
$2,095
Roundtrip
found 10 hours ago
Select Ethiopian Airlines flight, departing Wed, Apr 29 from Chicago to São Tomé Island, returning Sun, May 3, priced at $2,095 found 10 hours ago
Wed, Apr 29 - Sun, May 3
ORD
Chicago
TMS
São Tomé Island
$2,165 Roundtrip, found 10 hours ago
$2,165
Roundtrip
found 10 hours ago
Select Ethiopian Airlines flight, departing Wed, Apr 29 from Chicago to São Tomé Island, returning Sun, May 3, priced at $2,165 found 10 hours ago
Wed, Apr 29 - Sun, May 3
ORD
Chicago
TMS
São Tomé Island
$2,183 Roundtrip, found 10 hours ago
$2,183
Roundtrip
found 10 hours ago
Select Ethiopian Airlines flight, departing Wed, Apr 29 from Chicago to São Tomé Island, returning Sun, May 3, priced at $2,183 found 10 hours ago

Hotel Ideas near São Tomé Intl.

Airport Hotels near São Tomé Intl.

Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection

4 out of 5
Praia Lagarto São Tomé
$209 nightly
The price is $243 total per night from Mar 26 to Mar 27
$243 total
Mar 26 - Mar 27
Total with taxes and fees
Book a stay at this beach resort in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon Téla Chocolate ...
9.4/10 Exceptional! (63 reviews)
Lovely hotel, staff and location. Very close to airport as well Recommend highly

Reviewed on Mar 8, 2026

Omali São Tomé – Principe Collection
Hotel Praia

Hotel Praia

3.5 out of 5
Praia Lagarto - Cx. Postal 61 São Tomé
$145 nightly
The price is $171 total per night from Mar 24 to Mar 25
$171 total
Mar 24 - Mar 25
Total with taxes and fees
Book a stay at this business-friendly hotel in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon ...
Hotel Praia
Praia Accommodation

Praia Accommodation

3 out of 5
Praia Lagarto São Tomé São Tomé
$126 nightly
The price is $145 total per night from Mar 24 to Mar 25
$145 total
Mar 24 - Mar 25
Total with taxes and fees
Book a stay at this beach B&B in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon Téla Chocolate ...
7.4/10 Good! (19 reviews)
Great place to stay

Reviewed on Nov 21, 2024

Praia Accommodation
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In São Tomé Island

Pestana São Tomé

Pestana São Tomé

5 out of 5
Avenida Marginal 12 De Julho São Tomé
$198 nightly
The price is $228 total per night from Mar 25 to Mar 26
$228 total
Mar 25 - Mar 26
Total with taxes and fees
Book a stay at this luxury hotel in São Tomé. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Estadio Nacional 12 de Julho and Cloçon ...
8.2/10 Very Good! (79 reviews)
Wonderful stay, great staff, easy, relaxing delightful.

Reviewed on Dec 9, 2025

Pestana São Tomé
Omali São Tomé – Principe Collection

Omali São Tomé – Principe Collection

4 out of 5
Praia Lagarto São Tomé
$209 nightly
The price is $243 total per night from Mar 26 to Mar 27
$243 total
Mar 26 - Mar 27
Total with taxes and fees
Book a stay at this beach resort in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cloçon Téla Chocolate ...
9.4/10 Exceptional! (63 reviews)
Lovely hotel, staff and location. Very close to airport as well Recommend highly

Reviewed on Mar 8, 2026

Omali São Tomé – Principe Collection
Pestana Miramar São Tomé

Pestana Miramar São Tomé

3 out of 5
Avenida Marginal 12 De Julho São Tomé
$144 nightly
The price is $165 total per night from Mar 25 to Mar 26
$165 total
Mar 25 - Mar 26
Total with taxes and fees
Book a stay at this beach resort in São Tomé. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Estadio Nacional 12 de Julho and São ...
Pestana Miramar São Tomé
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

ORD to TMS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
ORD Address & GPS
Address:
10000 West O'Hare
Chicago IL, 60666
United States
IATA Code:
ORD
Longitude:
-87.904876
Latitude:
41.976912
Time Zone:
America/Chicago
TMS Address & GPS
Address:
Sao Tome Island ,
Sao Tome and Principe
IATA Code:
TMS
Longitude:
6.725
Latitude:
0.378333
Time Zone:
Africa/Sao_Tome

Frequently asked questions

What is the shortest flight from O'Hare Airport to TMS?
Choose your favorite seat, because you'll be sitting in it for quite some time on your Chicago to São Tomé Island journey. The fastest possible flight time from O'Hare Airport to Sao Tome Intl. Airport (TMS) is 14 hours and 25 minutes.
How many hours flight from O'Hare Intl. Airport (ORD) to Sao Tome Intl. Airport?
With a flight time of around 14 hours and 25 minutes, traveling from ORD to TMS is no short trip. Get set for some long hours in the sky and think about using your air miles to upgrade.
What airlines have the most flights from O'Hare Airport to Sao Tome Intl. Airport?
Currently, there are no airlines that advertise direct flights between O'Hare Airport and Sao Tome Intl. Airport. But never fear. There are plenty of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.