Cheap flights from DTW to TMS (Detroit Metropolitan Wayne County to São Tomé Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from DTW to TMS starting at One Way, $2,981 Round Trip

Prices starting at $2,981 for return flights and for one-way flights to São Tomé Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 25 - Sat, Nov 1
DTW
Detroit
TMS
São Tomé Island
$2,981 Roundtrip, found 2 days ago
$2,981
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Sat, Oct 25 from Detroit to São Tomé Island, returning Sat, Nov 1, priced at $2,981 found 2 days ago
Sat, Oct 25 - Sat, Nov 1
DTW
Detroit
TMS
São Tomé Island
$3,008 Roundtrip, found 2 days ago
$3,008
Roundtrip
found 2 days ago
Select TAP Portugal flight, departing Sat, Oct 25 from Detroit to São Tomé Island, returning Sat, Nov 1, priced at $3,008 found 2 days ago
Sat, Oct 25 - Sat, Nov 1
DTW
Detroit
TMS
São Tomé Island
$3,041 Roundtrip, found 2 days ago
$3,041
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Sat, Oct 25 from Detroit to São Tomé Island, returning Sat, Nov 1, priced at $3,041 found 2 days ago
Sat, Oct 25 - Sat, Nov 1
DTW
Detroit
TMS
São Tomé Island
$3,466 Roundtrip, found 2 days ago
$3,466
Roundtrip
found 2 days ago
Select TAP Portugal flight, departing Sat, Oct 25 from Detroit to São Tomé Island, returning Sat, Nov 1, priced at $3,466 found 2 days ago
Sat, Oct 25 - Sat, Nov 1
DTW
Detroit
TMS
São Tomé Island
$3,483 Roundtrip, found 2 days ago
$3,483
Roundtrip
found 2 days ago
Select TAP Portugal flight, departing Sat, Oct 25 from Detroit to São Tomé Island, returning Sat, Nov 1, priced at $3,483 found 2 days ago
Mon, Jun 9 - Wed, Jun 11
DTW
Detroit
TMS
São Tomé Island
$4,143 Roundtrip, found 1 day ago
$4,143
Roundtrip
found 1 day ago
Select TAP Portugal flight, departing Mon, Jun 9 from Detroit to São Tomé Island, returning Wed, Jun 11, priced at $4,143 found 1 day ago
Mon, Jun 9 - Wed, Jun 11
DTW
Detroit
TMS
São Tomé Island
$4,148 Roundtrip, found 1 day ago
$4,148
Roundtrip
found 1 day ago
Select TAP Portugal flight, departing Mon, Jun 9 from Detroit to São Tomé Island, returning Wed, Jun 11, priced at $4,148 found 1 day ago
Mon, Jun 9 - Wed, Jun 11
DTW
Detroit
TMS
São Tomé Island
$4,156 Roundtrip, found 1 day ago
$4,156
Roundtrip
found 1 day ago
Select TAP Portugal flight, departing Mon, Jun 9 from Detroit to São Tomé Island, returning Wed, Jun 11, priced at $4,156 found 1 day ago
Mon, Jun 9 - Wed, Jun 11
DTW
Detroit
TMS
São Tomé Island
$4,158 Roundtrip, found 1 day ago
$4,158
Roundtrip
found 1 day ago
Select TAP Portugal flight, departing Mon, Jun 9 from Detroit to São Tomé Island, returning Wed, Jun 11, priced at $4,158 found 1 day ago
Mon, Jun 9 - Wed, Jun 11
DTW
Detroit
TMS
São Tomé Island
$4,161 Roundtrip, found 1 day ago
$4,161
Roundtrip
found 1 day ago
Select TAP Portugal flight, departing Mon, Jun 9 from Detroit to São Tomé Island, returning Wed, Jun 11, priced at $4,161 found 1 day ago

Hotel Ideas near São Tomé Intl.

Airport Hotels near São Tomé Intl.

Omali São Tomé – Principe Collection
Omali São Tomé – Principe Collection
4 out of 5
Praia Lagarto, São Tomé
Stay at this 4-star beach resort in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cathedral of São Tomé and São Sebastião ...
9.4/10 Exceptional! (58 reviews)
"The employees really make the property a superstar."

Reviewed on Feb 21, 2025

Get rates
Omali São Tomé – Principe Collection
Praia Accommodation
Praia Accommodation
3 out of 5
Praia Lagarto, São Tomé, São Tomé
Stay at this 3-star beach B&B in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our reviews. Popular ...
"Great place to stay"

Reviewed on Nov 21, 2024

Get rates
Praia Accommodation
Hotel Praia
Hotel Praia
3.5 out of 5
Praia Lagarto - Cx. Postal 61, São Tomé
Stay at this 3.5-star business-friendly hotel in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions São Sebastião Museum and Cathedral ...
"Pros: Room is very spacious and clean. Common areas also nice and generally I enjoyed a quiet atmosphere. Staff is nice, food is good. Cons: They did not honor the complementary airport transfer that is announced on line, they arranged a private taxi that charged me 20 US Dollars (for a 4 minute ..."

Reviewed on Dec 6, 2023

Get rates
Hotel Praia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In São Tomé Island

Pestana São Tomé
Pestana São Tomé
5 out of 5
Avenida Marginal 12 De Julho, São Tomé
Stay at this 5-star luxury hotel in São Tomé. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Estadio Nacional 12 de Julho and Cathedral ...
7.8/10 Good! (68 reviews)
"Good choice in São Tomé city."

Reviewed on Apr 5, 2025

Get rates
Pestana São Tomé
Omali São Tomé – Principe Collection
Omali São Tomé – Principe Collection
4 out of 5
Praia Lagarto, São Tomé
Stay at this 4-star beach resort in São Tomé. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cathedral of São Tomé and São Sebastião ...
9.4/10 Exceptional! (58 reviews)
"The employees really make the property a superstar."

Reviewed on Feb 21, 2025

Get rates
Omali São Tomé – Principe Collection
Pestana Miramar São Tomé
Pestana Miramar São Tomé
3 out of 5
Avenida Marginal 12 De Julho, São Tomé
Stay at this 3-star beach resort in São Tomé. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Estadio Nacional 12 de Julho and Cathedral ...
7/10 Good! (42 reviews)
"Very helpful and accommodating staff"

Reviewed on Jun 7, 2024

Get rates
Pestana Miramar São Tomé
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DTW to TMS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DTW Address & GPS
Address:
1 Detroit Metro Airport
Detroit MI, 48242
United States
IATA Code:
DTW
Longitude:
-83.356048
Latitude:
42.207808
Time Zone:
America/New_York
TMS Address & GPS
Address:
Sao Tome Island ,
Sao Tome and Principe
IATA Code:
TMS
Longitude:
6.725
Latitude:
0.378333
Time Zone:
Africa/Sao_Tome

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.