$52 Cheap flight deals from Biloxi (MOB) to Seneca (GSP)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Biloxi to Seneca

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jan 4 - Tue, Jan 20
MSY
Louis Armstrong New Orleans Intl.
GSP
Greenville-Spartanburg Intl.
$426 Roundtrip, found 17 hours ago
$426
Roundtrip
found 17 hours ago
Select Delta flight, departing Sun, Jan 4 from Louis Armstrong New Orleans Intl. to Greenville-Spartanburg Intl., returning Tue, Jan 20, priced at $426 found 17 hours ago

Airfares from $52 One Way, $103 Round Trip from Biloxi to Seneca

Prices starting at $103 for return flights and $52 for one-way flights to Seneca were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Feb 5 - Sun, Feb 8
MSY
New Orleans
GSP
Greenville
$103 Roundtrip, found 17 hours ago
$103
Roundtrip
found 17 hours ago
Select Breeze Airways flight, departing Thu, Feb 5 from New Orleans to Greenville, returning Sun, Feb 8, priced at $103 found 17 hours ago
Thu, Feb 5 - Sun, Feb 8
MSY
New Orleans
GSP
Greenville
$106 Roundtrip, found 1 day ago
$106
Roundtrip
found 1 day ago
Select Breeze Airways flight, departing Thu, Feb 5 from New Orleans to Greenville, returning Sun, Feb 8, priced at $106 found 1 day ago
Thu, Feb 12 - Sun, Feb 15
MSY
New Orleans
GSP
Greenville
$148 Roundtrip, found 2 days ago
$148
Roundtrip
found 2 days ago
Select Breeze Airways flight, departing Thu, Feb 12 from New Orleans to Greenville, returning Sun, Feb 15, priced at $148 found 2 days ago
Thu, Feb 26 - Sun, Mar 1
MSY
New Orleans
GSP
Greenville
$200 Roundtrip, found 1 day ago
$200
Roundtrip
found 1 day ago
Select Breeze Airways flight, departing Thu, Feb 26 from New Orleans to Greenville, returning Sun, Mar 1, priced at $200 found 1 day ago
Thu, Feb 26 - Sun, Mar 1
MSY
New Orleans
GSP
Greenville
$216 Roundtrip, found 4 days ago
$216
Roundtrip
found 4 days ago
Select Breeze Airways flight, departing Thu, Feb 26 from New Orleans to Greenville, returning Sun, Mar 1, priced at $216 found 4 days ago

Seneca economy flight packages

Price found within the past 48 hours. Click for updated prices.
Comfort Inn & Suites Greer - Greenville
2.5-star property

Comfort Inn & Suites Greer - Greenville

8.6/10 Excellent! (711 reviews)

Feb 5 - Feb 8

3 night stay

Mobile (MOB) to Greenville (GSP)

Delta • Non-stop roundtrip • Coach
Price was $548, price is now $449 per person
$449
per person
found 1 day ago
Extremely clean,quite and very affordable

Reviewed on Sep 2, 2025

Hotel Hartness
4.0-star property

Hotel Hartness

9.8/10 Exceptional! (613 reviews)

Feb 5 - Feb 8

3 night stay

Mobile (MOB) to Greenville (GSP)

Delta • Non-stop roundtrip • Coach
Price was $711, price is now $549 per person
$549
per person
found 1 day ago
First of all, LOVE the staff. We get drinks regularly at the hotel bar and the staff is amazing. We decided to stay in the hotel for a special occasion even though we have been loyal local customers since the restaurant and hotel opened. Overall, the experience was ok. The rooms are like a typical Hyatt or Hilton- nothing special. Our biggest issue was with breakfast. It was also ok, but sparse. Waiting for another batch of eggs to be cooked is understandable, but not having the pastries or cups restocked shows a lack of desire when the employee is standing there on her phone. And there must have been 7 employees standing around and snacking on the breakfast items around the time it closed, which is very bad optics. Our biggest issues was that the coffee was moved to the bar after breakfast but the creamer was spoiled. It appeared that it had not been refrigerated and was actually curdled; chunks came into our coffee cups. I think that Hotel Hartness needs to lean less on the architecture and surroundings and more on the little things that make a hotel experience something that is above average.

Reviewed on Mar 18, 2025

Grand Bohemian Lodge Greenville, Autograph Collection
4.0-star property

Grand Bohemian Lodge Greenville, Autograph Collection

9.6/10 Exceptional! (406 reviews)

Feb 5 - Feb 8

3 night stay

Mobile (MOB) to Greenville (GSP)

Delta • Non-stop roundtrip • Coach
Price was $1,001, price is now $824 per person
$824
per person
found 1 day ago
Loved the location, attention to design details in all spaces, complimentary cocktails and delicious lunch in hotel restaurant. Really used the swamp rabbit trail right outside…

Reviewed on Nov 23, 2025

Don't see what you're looking for?
See all available trips from Biloxi to Seneca
View all trips

More About Flying To Seneca from Biloxi

Route Information for Flights from Biloxi to Seneca

Origin Airport IATA Code
MOB
Destination Airport IATA Code
GSP
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Biloxi to Seneca

Biloxi to Seneca flights are offered at fantastic discount by Orbitz. Book air tickets now and cut those extra costs out of your travel budget to ensure a rewarding travel experience. With guaranteed low prices like these, can you afford to miss this discount?

Book cheap flights from Biloxi to Seneca

Cheap airfares are available on flights from Biloxi to Seneca. Use Orbitz to find the best flights that suit both your budget and the travel times that you need. Travelers who are looking for discounted rates on domestic or international flights need to look no further than Orbitz.

Orbitz goes mobile

As the world of technology rapidly expands around us, we are continuously finding new ways to improve our services, communications, and accessibility. With our cutting-edge mobile tools now available on Android, iPhone, and tablets, you can access detailed information on your bookings for flights from Biloxi to Seneca at any time or anywhere. See your itinerary for your Biloxi to Seneca flights, baggage and gate claim details, as well as hotel deals with our easy-to-use apps.

Get a great package with your Biloxi to Seneca flights

With frequent updates on your flight status, including delays and changes in bookings, traveling becomes more hassle-free than ever. Not only do we offer huge discounted deals on flights from Biloxi to Seneca, we also have fantastic savings on vacation packages, hotel room, cruises, activities, and car rentals so you can pick and choose and create the best travel package for you.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.