
$126 Cheap flight deals from Panama City (PNS) to Middlesboro (TYS)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
Airfares from $126 One Way, $267 Round Trip from Panama City to Middlesboro
Prices starting at $267 for return flights and $126 for one-way flights to Middlesboro were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Middlesboro economy flight packages

River Terrace Resort & Convention Center
Jun 5 - Jun 7
Pensacola (PNS) to Knoxville (TYS)
Reviewed on Jun 20, 2025

The Ramsey Hotel and Convention Center Pigeon Forge
May 15 - May 19
Pensacola (PNS) to Knoxville (TYS)
Reviewed on Jan 19, 2026

The Lodge at Camp Margaritaville
May 15 - May 19
Pensacola (PNS) to Knoxville (TYS)
Reviewed on Oct 8, 2023
More About Flying To Middlesboro from Panama City
Route Information for Flights from Panama City to Middlesboro
Origin Airport IATA Code | PNS |
|---|---|
Destination Airport IATA Code | TYS |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Panama City to Middlesboro
For the best available deals on flights from Panama City to Middlesboro, look no further than Orbitz. Offering the perfect packages with cutting-edge mobile tools, Orbitz is your ideal destination.
One Stop Travel Shop
Not only is Orbitz the best source for great deals on flights from Panama City to Middlesboro, we offer the complete package. From guaranteed low prices on hotels, car rentals and activities, simply decide what you want and Orbitz will put together the complete vacation package.
Searching Anywhere
Booking Panama City to Middlesboro flights is simple, wherever you are. Book on your computer and the Orbitz Display Matrix gives all your deals and discounts on flights from Panama City to Middlesboro, showing your great savings. Or if you are on the move, use m.orbitz.com on your mobile browser to find exclusive Panama City to Middlesboro flights for mobile users.
Worry-free Travel Planning
Orbitz is the best place for Panama City to Middlesboro flights at guaranteed low prices, we also take the stress out of your flight details. With our free alerts service you can quickly find out your gate number or flight delays via email or text – perfect if you are in a rush.
Miles Better
If you frequently travel on flights from Panama City to Middlesboro, it’s easy to rack up your air miles. Just add your frequent flyer number when booking your flights and we will do the rest. Orbitz will even store your number in your profile to automatically add on your miles each time you book.
Middlesboro Airports
More Destinations
- Flights from Houston to London
- Flights from London to London
- Flights from Minneapolis - St. Paul to London
- Flights from Nashville to London
- Flights from Seoul to London
- Flights from Frankfurt to London
- Flights from Delhi to London
- Flights from New Haven to London
- Flights from Panama City to London
- Flights from Birmingham to London
- Flights from Cape Town to London
- Flights from Tallahassee to London
- Flights from Mumbai to London
- Flights from Bangor to London
- Flights from San Salvador to London
- Flights from Wichita to London
- Flights from Covington to London
- Flights from Sioux Falls to London
- Flights from Rabat to London
- Flights from Hiroshima to London
- Flights from Lubbock to London
- Flights from Bozeman to London
- Flights from St. Petersburg - Clearwater to Berea
- Flights from Dresden to Lake Cumberland
- Flights from Shanghai to Slade
- Flights from Duluth to Williamsburg
- Flights from Florence to Williamsburg
- Flights from Flint to Williamsburg
- Flights from Grand Junction to Williamsburg
- Flights from Killeen to Williamsburg
- Flights from Austin to Williamsburg
- Flights from Baltimore to Williamsburg
- Flights from Calgary to Williamsburg
- Flights from Dallas to Williamsburg
- Flights from Denver to Williamsburg
- Flights from Detroit to Williamsburg
- Flights from Lisbon District to Williamsburg
- Flights from Minneapolis - St. Paul to Williamsburg
- Flights from Phoenix to Williamsburg
- Flights from Salt Lake City to Williamsburg
- Flights from San Antonio to Williamsburg
- Flights from San Francisco to Williamsburg
- Flights from Vancouver to Williamsburg
- Flights from Washington to Williamsburg
- Flights from Venice to Williamsburg
- Flights from Charleston to Williamsburg
- Flights from Delhi to Williamsburg
- Flights from Shanghai to Williamsburg
- Flights from New Haven to Williamsburg
- Flights from Sacramento to Williamsburg
- Flights from Palm Springs to Williamsburg
- Flights from Lewiston to Williamsburg
- Flights from Montrose to Williamsburg
- Flights from Omaha to Williamsburg
- Flights from Albany to Williamsburg
- Flights from Eureka to Williamsburg
- Flights from Roanoke to Williamsburg
- Flights from St. George to Williamsburg
- Flights from Myrtle Beach to Williamsburg
- Flights from Pittsburgh to Williamsburg
- Flights from Toledo to Williamsburg
- Flights from Tulsa to Williamsburg
- Flights from Brunswick to Williamsburg
- Flights from Albuquerque to Williamsburg
- Flights from Buffalo to Williamsburg
- Flights from Medford to Williamsburg
- Flights from Little Rock to Williamsburg
- Flights from Oklahoma City to Williamsburg
- Flights from Allentown to Williamsburg
- Flights from Boise to Williamsburg
- Flights from Louisville to Williamsburg
- Flights from Binghamton to Williamsburg
- Flights from Asheville to Williamsburg
- Flights from Fayetteville to Williamsburg
- Flights from Cheyenne to Williamsburg
- Flights from Virginia to Williamsburg
- Flights from Corpus Christi to Williamsburg
- Flights from Montgomery to Pikeville
- Flights from Austin to Richmond
- Flights from Minneapolis - St. Paul to Richmond
- Flights from Sydney to Richmond
- Flights from Washington to Richmond
- Flights from St. George to Richmond
- Flights from Brunswick to Richmond
- Flights from Cedar Rapids - Iowa City to Richmond
- Flights from Fresno to Richmond
- Flights from Louisville to Richmond
- Flights from Baton Rouge to Richmond
- Flights from Grand Rapids to Richmond
- Flights from Albany to Richmond
- Flights from Binghamton to Richmond
- Flights from Bangor to Richmond
- Flights from Tampico to Richmond
- Flights from Hyderabad to Richmond
- Flights from Guatemala City to Richmond
- Flights from Ithaca to Richmond
- Flights from Newport News to Richmond
- Flights from Bismarck to Richmond
- Flights from Bozeman to Richmond
- Flights from New York to General Burnside State Park
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.


