$155 Cheap flight deals from Myrtle Beach (MYR) to San Diego (SAN)

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Airfares from $155 One Way, $299 Round Trip from Myrtle Beach to San Diego

Prices starting at $299 for return flights and $155 for one-way flights to San Diego were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, May 27 - Tue, Jun 2
MYR
Myrtle Beach
SAN
San Diego
$299 Roundtrip, found 5 days ago
$299
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, May 27 from Myrtle Beach to San Diego, returning Tue, Jun 2, priced at $299 found 5 days ago
Wed, May 27 - Tue, Jun 2
MYR
Myrtle Beach
SAN
San Diego
$299 Roundtrip, found 5 days ago
$299
Roundtrip
found 5 days ago
Select United flight, departing Wed, May 27 from Myrtle Beach to San Diego, returning Tue, Jun 2, priced at $299 found 5 days ago
Wed, May 27 - Tue, Jun 2
MYR
Myrtle Beach
SAN
San Diego
$299 Roundtrip, found 5 days ago
$299
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, May 27 from Myrtle Beach to San Diego, returning Tue, Jun 2, priced at $299 found 5 days ago
Wed, May 27 - Tue, Jun 2
MYR
Myrtle Beach
SAN
San Diego
$303 Roundtrip, found 5 days ago
$303
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 27 from Myrtle Beach to San Diego, returning Tue, Jun 2, priced at $303 found 5 days ago
Wed, May 27 - Tue, Jun 2
MYR
Myrtle Beach
SAN
San Diego
$304 Roundtrip, found 5 days ago
$304
Roundtrip
found 5 days ago
Select United flight, departing Wed, May 27 from Myrtle Beach to San Diego, returning Tue, Jun 2, priced at $304 found 5 days ago

San Diego economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel
3.5-star property

The Sofia Hotel

8.6/10 Excellent! (1,818 reviews)

May 7 - May 10

3 night stay

Myrtle Beach (MYR) to San Diego (SAN)

American Airlines • Non-stop roundtrip • Coach
Price was $919, price is now $688 per person
$688
per person
found 1 day ago
Beautiful historical hotel, amazing location a few minutes from the port, incredibly fast checkin, room had character and stay was perfect

Reviewed on Jan 5, 2026

The Beau Hotel Gaslamp Quarter San Diego
3.0-star property

The Beau Hotel Gaslamp Quarter San Diego

9/10 Wonderful! (636 reviews)

May 7 - May 10

3 night stay

Myrtle Beach (MYR) to San Diego (SAN)

American Airlines • Non-stop roundtrip • Coach
Price was $1,008, price is now $803 per person
$803
per person
found 1 day ago
overall, a nice stay. decor very spot on in keeping classic feel. Beautiful bar. Staffed with ABSOLUTELY lovely people! Only non-positives; no elevator, no fridge, portable AC unit.

Reviewed on Aug 28, 2025

Margaritaville Hotel San Diego Gaslamp Quarter
4.0-star property

Margaritaville Hotel San Diego Gaslamp Quarter

9/10 Wonderful! (1,259 reviews)

May 7 - May 10

3 night stay

Myrtle Beach (MYR) to San Diego (SAN)

American Airlines • Non-stop roundtrip • Coach
Price was $982, price is now $797 per person
$797
per person
found 1 day ago
We were able to check in early and check out late, but of course had to pay a fee

Reviewed on Oct 3, 2025

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More About Flying To San Diego from Myrtle Beach

Route Information for Flights from Myrtle Beach to San Diego

Origin Airport IATA Code
MYR
Destination Airport IATA Code
SAN
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Myrtle Beach to San Diego

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With the best deals and easy searching options, Orbitz make it easy and fun to find cheap Myrtle Beach to San Diego flights, a great hotel, or a full vacation package. With Orbitz’s low price guarantee, you always get great discounts on air ticket prices.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.