$135 Cheap flight deals from Seattle (SEA) to Southeast Missouri (STL)

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This Weekend's Flight Deals from Seattle to Southeast Missouri

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jun 14 - Tue, Jun 16
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$443 Roundtrip, found 1 day ago
$443
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sun, Jun 14 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $443 found 1 day ago
Sat, Jun 13 - Mon, Jul 6
PAE
Seattle Paine Field Intl. Airport
STL
Lambert-St. Louis Intl.
$668 Roundtrip, found 5 days ago
$668
Roundtrip
found 5 days ago
Select Alaska Airlines flight, departing Sat, Jun 13 from Seattle Paine Field Intl. Airport to Lambert-St. Louis Intl., returning Mon, Jul 6, priced at $668 found 5 days ago

Airfares from $135 One Way, $279 Round Trip from Seattle to Southeast Missouri

Prices starting at $279 for return flights and $135 for one-way flights to Southeast Missouri were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Sep 19 - Thu, Sep 24
SEA
Seattle
STL
St. Louis
$279 Roundtrip, found 2 days ago
$279
Roundtrip
found 2 days ago
Select United flight, departing Sat, Sep 19 from Seattle to St. Louis, returning Thu, Sep 24, priced at $279 found 2 days ago
Wed, Jul 15 - Mon, Jul 20
SEA
Seattle
STL
St. Louis
$285 Roundtrip, found 1 day ago
$285
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 15 from Seattle to St. Louis, returning Mon, Jul 20, priced at $285 found 1 day ago
Wed, Sep 30 - Sun, Oct 4
SEA
Seattle
STL
St. Louis
$330 Roundtrip, found 5 days ago
$330
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, Sep 30 from Seattle to St. Louis, returning Sun, Oct 4, priced at $330 found 5 days ago
Sun, Aug 9 - Sat, Aug 15
SEA
Seattle
STL
St. Louis
$371 Roundtrip, found 10 hours ago
$371
Roundtrip
found 10 hours ago
Select Southwest Airlines flight, departing Sun, Aug 9 from Seattle to St. Louis, returning Sat, Aug 15, priced at $371 found 10 hours ago
Fri, Oct 9 - Mon, Oct 12
SEA
Seattle
STL
St. Louis
$390 Roundtrip, found 5 days ago
$390
Roundtrip
found 5 days ago
Select Bargain Flight flight, departing Fri, Oct 9 from Seattle to St. Louis, returning Mon, Oct 12, priced at $390 found 5 days ago

Southeast Missouri economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
3.5-star property

The Wildwood Hotel

9.2/10 Wonderful! (1,657 reviews)

Jul 20 - Jul 26

6 night stay

Seattle (SEA) to St. Louis (STL)

Southwest Airlines • Non-stop • Coach

St. Louis (STL) to Seattle (SEA)

American Airlines • Non-stop • Coach
Save 100% on your flight
Price was $1,266, price is now $763 per person
$763
per person
found 17 hours ago
Hotel was clean but honestly, outdated. Staff was great. The continental breakfast was fine. Biggest issue was the shower. There was next to no water pressure no matter the time of day. The mattress also felt cheap. I’m not a picky person and overall, I would stay again. Just maybe not in an upgraded room. I don’t feel like it was worth it.

Reviewed on Feb 24, 2026

The Cheshire
4.0-star property

The Cheshire

8.8/10 Excellent! (1,007 reviews)

Jul 20 - Jul 26

6 night stay

Seattle (SEA) to St. Louis (STL)

Southwest Airlines • Non-stop • Coach

St. Louis (STL) to Seattle (SEA)

American Airlines • Non-stop • Coach
Price was $1,272, price is now $965 per person
$965
per person
found 17 hours ago
It was a lovely, British literature themed hotel with wonderful decor and amenities. Would highly recommend and stay again when in the St louis area.

Reviewed on May 4, 2026

The Principal Hotel
3.5-star property

The Principal Hotel

9.8/10 Exceptional! (278 reviews)

Jul 20 - Jul 26

6 night stay

Seattle (SEA) to St. Louis (STL)

Southwest Airlines • Non-stop • Coach

St. Louis (STL) to Seattle (SEA)

American Airlines • Non-stop • Coach
Price was $1,109, price is now $859 per person
$859
per person
found 17 hours ago
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More About Flying To Southeast Missouri from Seattle

Route Information for Flights from Seattle to Southeast Missouri

Origin Airport IATA Code
SEA
Destination Airport IATA Code
STL
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Seattle to Southeast Missouri

Orbitz is the best place to find guaranteed low prices on Seattle to Southeast Missouri flights. Because of our cutting-edge mobile tools and low fares on domestic and international flights, Orbitz is the best starting point for travelers.

Find Cheap Seattle to Southeast Missouri Flights

Orbitz offers free mobile apps for iPhone and Android devices—a great way to find fantastic deals on flights from Seattle to Southeast Missouri. Not only that, but you can check the status of your flight or even book low cost hotel rooms with the apps or on m.orbitz.com.

Get Miles and Points for Your Flight

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Discount Travel Planning Made Simple

You will have no problems finding budget flights from Seattle to Southeast Missouri on Orbitz.com. If your travel plans are flexible, you can search for fares three days before and after a specific date to find the best price.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.