Cheap flights from DSM to MDT (Des Moines Intl. to Harrisburg Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from DSM to MDT starting at $161 One Way, $269 Round Trip

Prices starting at $269 for return flights and $161 for one-way flights to Harrisburg Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Mar 29 - Tue, Apr 14
DSM
Des Moines
MDT
Harrisburg
$269 Roundtrip, found 21 hours ago
$269
Roundtrip
found 21 hours ago
Select Delta flight, departing Sun, Mar 29 from Des Moines to Harrisburg, returning Tue, Apr 14, priced at $269 found 21 hours ago
Wed, Apr 1 - Tue, Apr 14
DSM
Des Moines
MDT
Harrisburg
$271 Roundtrip, found 21 hours ago
$271
Roundtrip
found 21 hours ago
Select Delta flight, departing Wed, Apr 1 from Des Moines to Harrisburg, returning Tue, Apr 14, priced at $271 found 21 hours ago
Tue, Mar 17 - Sun, Mar 29
DSM
Des Moines
MDT
Harrisburg
$275 Roundtrip, found 21 hours ago
$275
Roundtrip
found 21 hours ago
Select Delta flight, departing Tue, Mar 17 from Des Moines to Harrisburg, returning Sun, Mar 29, priced at $275 found 21 hours ago
Sun, Mar 22 - Sat, Apr 11
DSM
Des Moines
MDT
Harrisburg
$278 Roundtrip, found 21 hours ago
$278
Roundtrip
found 21 hours ago
Select Delta flight, departing Sun, Mar 22 from Des Moines to Harrisburg, returning Sat, Apr 11, priced at $278 found 21 hours ago
Wed, Apr 22 - Sat, May 9
DSM
Des Moines
MDT
Harrisburg
$303 Roundtrip, found 21 hours ago
$303
Roundtrip
found 21 hours ago
Select Delta flight, departing Wed, Apr 22 from Des Moines to Harrisburg, returning Sat, May 9, priced at $303 found 21 hours ago

Hotel Ideas near Harrisburg Intl.

Airport Hotels near Harrisburg Intl.

Fairfield Inn & Suites by Marriott Harrisburg International Airport

Fairfield Inn & Suites by Marriott Harrisburg International Airport

2.5 out of 5
4 Terminal Drive Middletown PA
$159 nightly
The price is $176 total per night from Jan 29 to Jan 30
$176 total
Jan 29 - Jan 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Middletown. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (1,001 reviews)
great!

Reviewed on Jan 23, 2026

Fairfield Inn & Suites by Marriott Harrisburg International Airport
Holiday Inn Harrisburg East by IHG

Holiday Inn Harrisburg East by IHG

3 out of 5
815 South Eisenhower Boulevard Middletown PA
$67 nightly
The price is $74 total per night from Jan 30 to Jan 31
$74 total
Jan 30 - Jan 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Middletown. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
7.2/10 Good! (956 reviews)
Yes

Reviewed on Jan 21, 2026

Holiday Inn Harrisburg East by IHG
La Quinta Inn & Suites by Wyndham Harrisburg Airport Hershey

La Quinta Inn & Suites by Wyndham Harrisburg Airport Hershey

3 out of 5
990 Eisenhower Blvd Harrisburg PA
$50 nightly
The price is $56 total per night from Jan 28 to Jan 29
$56 total
Jan 28 - Jan 29
Total with taxes and fees
Stay at this hotel in Harrisburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
7.6/10 Good! (1,010 reviews)
Nick the manager was extremely helpful and accommodating. I arrived earlier than expected and he allowed me the check in and I was so grateful. The room was clean and the housekeeper was very kind. The breakfast was. a plus and was plentiful. I will be returning soon!!!

Reviewed on Jan 23, 2026

La Quinta Inn & Suites by Wyndham Harrisburg Airport Hershey
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Harrisburg

Fairfield Inn & Suites by Marriott Harrisburg International Airport

Fairfield Inn & Suites by Marriott Harrisburg International Airport

2.5 out of 5
4 Terminal Drive Middletown PA
$159 nightly
The price is $176 total per night from Jan 29 to Jan 30
$176 total
Jan 29 - Jan 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Middletown. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (1,001 reviews)
great!

Reviewed on Jan 23, 2026

Fairfield Inn & Suites by Marriott Harrisburg International Airport
Holiday Inn Harrisburg East by IHG

Holiday Inn Harrisburg East by IHG

3 out of 5
815 South Eisenhower Boulevard Middletown PA
$67 nightly
The price is $74 total per night from Jan 30 to Jan 31
$74 total
Jan 30 - Jan 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Middletown. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
7.2/10 Good! (956 reviews)
Yes

Reviewed on Jan 21, 2026

Holiday Inn Harrisburg East by IHG
Days Inn by Wyndham Hershey

Days Inn by Wyndham Hershey

2.5 out of 5
350 W Chocolate Ave Hershey PA
$85 nightly
The price is $95 total per night from Jan 28 to Jan 29
$95 total
Jan 28 - Jan 29
Total with taxes and fees
Book a stay at this family-friendly hotel in Hershey. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.6/10 Excellent! (1,892 reviews)
Was good

Reviewed on Jan 26, 2026

Days Inn by Wyndham Hershey
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Harrisburg Hotels With Airport Transportation

Holiday Inn Harrisburg East by IHG

Holiday Inn Harrisburg East by IHG

3 out of 5
815 South Eisenhower Boulevard Middletown PA
$67 nightly
The price is $74 total per night from Jan 30 to Jan 31
$74 total
Jan 30 - Jan 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Middletown. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
7.2/10 Good! (956 reviews)
Yes

Reviewed on Jan 21, 2026

Holiday Inn Harrisburg East by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Harrisburg

Holiday Inn Harrisburg East by IHG

Holiday Inn Harrisburg East by IHG

3 out of 5
815 South Eisenhower Boulevard Middletown PA
$67 nightly
The price is $74 total per night from Jan 30 to Jan 31
$74 total
Jan 30 - Jan 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Middletown. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
7.2/10 Good! (956 reviews)
Yes

Reviewed on Jan 21, 2026

Holiday Inn Harrisburg East by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to MDT Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

Are there non-stop flights from DSM to Harrisburg Intl. Airport?
As you can't fly straight from Des Moines Intl. Airport (DSM) to MDT, a flight with just one stop is your best option. American Airlines, Delta Air Lines and KLM are reputable airlines that service this route.
What is the shortest flight from Des Moines Intl. Airport (DSM) to MDT?
The shortest flight from Des Moines Intl. Airport (DSM) to MDT is 4 hours and 3 minutes. Slip a few things into your hand luggage to keep you entertained, like the latest edition of your favorite magazine or some Sudoku puzzles.
How many hours flight from Des Moines Intl. Airport to Harrisburg Intl. Airport?
The flight from DSM to MDT takes an average of 4 hours and 9 minutes. A couple of movies, some podcasts and a nice snooze will help make time zoom by.
What airlines have the most flights from Des Moines Intl. Airport to Harrisburg Intl. Airport?
Currently, there are no airlines that fly direct between Des Moines Intl. Airport and MDT. Don't panic though! There are loads of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.