Cheap flights from BUF to MSL (Buffalo Niagara Intl. to Northwest Alabama Regional)

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Cheap Flights from BUF to MSL starting at One Way, $545 Round Trip

Prices starting at $545 for return flights and for one-way flights to Northwest Alabama Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Feb 10 - Tue, Feb 17
BUF
Buffalo
MSL
Muscle Shoals
$545 Roundtrip, found 1 day ago
$545
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Feb 10 from Buffalo to Muscle Shoals, returning Tue, Feb 17, priced at $545 found 1 day ago
Tue, Feb 10 - Tue, Feb 17
BUF
Buffalo
MSL
Muscle Shoals
$555 Roundtrip, found 1 day ago
$555
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Feb 10 from Buffalo to Muscle Shoals, returning Tue, Feb 17, priced at $555 found 1 day ago
Tue, Feb 10 - Tue, Feb 17
BUF
Buffalo
MSL
Muscle Shoals
$560 Roundtrip, found 1 day ago
$560
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Feb 10 from Buffalo to Muscle Shoals, returning Tue, Feb 17, priced at $560 found 1 day ago
Tue, Feb 10 - Tue, Feb 17
BUF
Buffalo
MSL
Muscle Shoals
$603 Roundtrip, found 1 day ago
$603
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Feb 10 from Buffalo to Muscle Shoals, returning Tue, Feb 17, priced at $603 found 1 day ago
Tue, Feb 10 - Tue, Feb 17
BUF
Buffalo
MSL
Muscle Shoals
$608 Roundtrip, found 1 day ago
$608
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Feb 10 from Buffalo to Muscle Shoals, returning Tue, Feb 17, priced at $608 found 1 day ago

Hotel Ideas near Northwest Alabama Regional

Airport Hotels near Northwest Alabama Regional

Days Inn by Wyndham Muscle Shoals Florence

Days Inn by Wyndham Muscle Shoals Florence

2 out of 5
2701 Woodward Ave Muscle Shoals AL
$66 nightly
The price is $74 total per night from Mar 1 to Mar 2
$74 total
Mar 1 - Mar 2
Total with taxes and fees
Stay at this hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
Staff was extremely courteous my stay was very pleasant

Reviewed on Feb 1, 2026

Days Inn by Wyndham Muscle Shoals Florence
Muscle Shoals Home < 3 Mi to Recording Studios!

Muscle Shoals Home < 3 Mi to Recording Studios!

3 out of 5
Muscle Shoals AL
Stay at this cottage in Muscle Shoals. Enjoy free parking, a marina, and in-room fireplaces. Popular attractions Fame Recording Studios and Nature Trails Trailhead ...
Get rates
Muscle Shoals Home < 3 Mi to Recording Studios!
3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital

3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital

2 out of 5
Muscle Shoals AL
$267 nightly
The price is $293 total per night from Feb 9 to Feb 10
$293 total
Feb 9 - Feb 10
Total with taxes and fees
Stay at this vacation home in Muscle Shoals. Enjoy private pools, laundry facilities, and patios. Popular attractions Fame Recording Studios and Muscle Shoals ...
9.6/10 Exceptional! (46 reviews)
Great house. Plenty of space and everything we needed. Cooked, grilled, had a great time. Owner is very responsive!

Reviewed on Jan 4, 2026

3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Muscle Shoals

Days Inn by Wyndham Muscle Shoals Florence

Days Inn by Wyndham Muscle Shoals Florence

2 out of 5
2701 Woodward Ave Muscle Shoals AL
$66 nightly
The price is $74 total per night from Mar 1 to Mar 2
$74 total
Mar 1 - Mar 2
Total with taxes and fees
Stay at this hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
Staff was extremely courteous my stay was very pleasant

Reviewed on Feb 1, 2026

Days Inn by Wyndham Muscle Shoals Florence
Red Roof Inn Muscle Shoals

Red Roof Inn Muscle Shoals

2.5 out of 5
2807 Woodward Ave Muscle Shoals AL
$75 nightly
The price is $83 total per night from Feb 8 to Feb 9
$83 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fame Recording Studios and ...
6.6/10 (306 reviews)
The staff was very friendly and helpful

Reviewed on Feb 6, 2026

Red Roof Inn Muscle Shoals
3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital

3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital

2 out of 5
Muscle Shoals AL
$267 nightly
The price is $293 total per night from Feb 9 to Feb 10
$293 total
Feb 9 - Feb 10
Total with taxes and fees
Stay at this vacation home in Muscle Shoals. Enjoy private pools, laundry facilities, and patios. Popular attractions Fame Recording Studios and Muscle Shoals ...
9.6/10 Exceptional! (46 reviews)
Great house. Plenty of space and everything we needed. Cooked, grilled, had a great time. Owner is very responsive!

Reviewed on Jan 4, 2026

3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Muscle Shoals Hotels

Days Inn by Wyndham Muscle Shoals Florence

Days Inn by Wyndham Muscle Shoals Florence

2 out of 5
2701 Woodward Ave Muscle Shoals AL
$66 nightly
The price is $74 total per night from Mar 1 to Mar 2
$74 total
Mar 1 - Mar 2
Total with taxes and fees
Stay at this hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
Staff was extremely courteous my stay was very pleasant

Reviewed on Feb 1, 2026

Days Inn by Wyndham Muscle Shoals Florence
Red Roof Inn Muscle Shoals

Red Roof Inn Muscle Shoals

2.5 out of 5
2807 Woodward Ave Muscle Shoals AL
$75 nightly
The price is $83 total per night from Feb 8 to Feb 9
$83 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fame Recording Studios and ...
6.6/10 (306 reviews)
The staff was very friendly and helpful

Reviewed on Feb 6, 2026

Red Roof Inn Muscle Shoals
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Muscle Shoals

Red Roof Inn Muscle Shoals

Red Roof Inn Muscle Shoals

2.5 out of 5
2807 Woodward Ave Muscle Shoals AL
$75 nightly
The price is $83 total per night from Feb 8 to Feb 9
$83 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fame Recording Studios and ...
6.6/10 (306 reviews)
The staff was very friendly and helpful

Reviewed on Feb 6, 2026

Red Roof Inn Muscle Shoals
Days Inn by Wyndham Muscle Shoals Florence

Days Inn by Wyndham Muscle Shoals Florence

2 out of 5
2701 Woodward Ave Muscle Shoals AL
$66 nightly
The price is $74 total per night from Mar 1 to Mar 2
$74 total
Mar 1 - Mar 2
Total with taxes and fees
Stay at this hotel in Muscle Shoals. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
Staff was extremely courteous my stay was very pleasant

Reviewed on Feb 1, 2026

Days Inn by Wyndham Muscle Shoals Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

BUF to MSL Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What airlines have the most flights from Buffalo Niagara Intl. Airport (BUF) to Northwest Alabama Regional Airport (MSL)?
If you're hoping to book with an airline that flies direct from BUF to Northwest Alabama Regional Airport (MSL), you won't have much luck. You'll need to book a flight with at least one stopover to get to your destination.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.