Hotels in Southeast Missouri

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Sep 30 - Oct 1
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Check prices in Southeast Missouri for tonight, Sep 30 - Oct 1
Oct 1 - Oct 2
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Top Rated Southeast Missouri Hotels

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.88 mi from city center
$100 nightly
The price is $113 total per night
$113 total
Oct 4 - Oct 5
Total with taxes and fees
At Drury Plaza Hotel Cape Girardeau Conference Center, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and a conference center.
Pool
Hot Tub
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
46.8 mi from city center
$72 nightly
The price is $81 total per night
$81 total
Oct 4 - Oct 5
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau West enjoy free WiFi in public areas, a 24-hour business center, and a TV in a common area. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations.
Breakfast included
Pet friendly
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Free Cancellation
Reserve now, pay when you stay
37.99 mi from city center
$57 nightly
The price is $62 total per night
$62 total
Oct 25 - Oct 26
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking and an area shuttle. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and a computer station.
Pool
Breakfast included
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Free Cancellation
68.39 mi from city center
$73 nightly
The price is $83 total per night
$83 total
Oct 25 - Oct 26
Total with taxes and fees
At Comfort Inn Festus - St Louis South, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. Front-desk staff can answer questions 24/7, and assist with securing valuables, dry cleaning/laundry, and tours or tickets. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Breakfast included
Parking included
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
50.35 mi from city center
$95 nightly
The price is $107 total per night
$107 total
Oct 26 - Oct 27
Total with taxes and fees
Guests of The Riverview enjoy features like a casino, free WiFi in public areas, and meeting rooms. If you decide to drive, there's free parking. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a conference center, a microwave in a common area, and wedding services.
Parking included
Free WiFi
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
54.11 mi from city center
$94 nightly
The price is $108 total per night
$108 total
Oct 4 - Oct 5
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with securing valuables, dry cleaning/laundry, and luggage storage. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
51.43 mi from city center
$141 nightly
The price is $160 total per night
$160 total
Oct 28 - Oct 29
Total with taxes and fees
At Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy, guests have access to features like express check-out. You can put free parking to good use if you drive.
Kitchen
Pet friendly
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Free Cancellation
Reserve now, pay when you stay
45.7 mi from city center
$84 nightly
The price is $91 total per night
$91 total
Oct 5 - Oct 6
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a vending machine.
Pool
Breakfast included
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
54.5 mi from city center
$66 nightly
The price is $76 total per night
$76 total
Oct 4 - Oct 5
Total with taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a vending machine.
Breakfast included
Pet friendly
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO
41.04 mi from city center
$312 nightly
The price is $351 total per night
$351 total
Oct 1 - Oct 2
Total with taxes and fees
At this vacation home, guests have access to features like laundry facilities.
Laundry
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
Free Cancellation
30.18 mi from city center
$84 nightly
The price is $95 total per night
$95 total
Oct 18 - Oct 19
Total with taxes and fees
At Holiday Inn Poplar Bluff by IHG, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The front desk is staffed 24/7 to help with dry cleaning/laundry, securing valuables, and concierge services. Additional amenities include meeting rooms, conference space, and a business center.
Pool
Pet friendly
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
30.36 mi from city center
$88 nightly
The price is $98 total per night
$98 total
Oct 18 - Oct 19
Total with taxes and fees
Guests of Hampton Inn Poplar Bluff have access to an indoor pool, a gym, and free WiFi in public areas. There's free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, dry cleaning/laundry, and luggage storage. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Cheap Southeast Missouri hotels options

    Motel 6 Poplar Bluff, MO

    Motel 6 Poplar Bluff, MO

    4101 Highway 67 N Poplar Bluff MO
    $79 nightly
    The price is $88 total per night from Oct 1 to Oct 2
    $88 total
    Oct 1 - Oct 2
    Total with taxes and fees
    8/10 Very Good! (1,001 reviews)
    Super 8 by Wyndham Farmington

    Super 8 by Wyndham Farmington

    930 Valley Creek Dr Farmington MO
    $60 nightly
    The price is $65 total per night from Oct 11 to Oct 12
    $65 total
    Oct 11 - Oct 12
    Total with taxes and fees
    8/10 Very Good! (681 reviews)
    Super 8 by Wyndham Pevely

    Super 8 by Wyndham Pevely

    1711 Highway Z Pevely MO
    $66 nightly
    The price is $75 total per night from Oct 25 to Oct 26
    $75 total
    Oct 25 - Oct 26
    Total with taxes and fees
    Pear Tree Inn Cape Girardeau West

    Pear Tree Inn Cape Girardeau West

    103 Cape West Pkwy Cape Girardeau MO
    $72 nightly
    The price is $81 total per night from Oct 4 to Oct 5
    $81 total
    Oct 4 - Oct 5
    Total with taxes and fees
    9.2/10 Wonderful! (1,007 reviews)
    Baymont Inn and Suites by Wyndham Farmington, MO

    Baymont Inn and Suites by Wyndham Farmington, MO

    1625 W Columbia St Farmington MO
    $57 nightly
    The price is $62 total per night from Oct 25 to Oct 26
    $62 total
    Oct 25 - Oct 26
    Total with taxes and fees
    8/10 Very Good! (1,001 reviews)
    Days Inn and Suites by Wyndham Sikeston

    Days Inn and Suites by Wyndham Sikeston

    220 S Interstate Dr Sikeston MO
    $66 nightly
    The price is $76 total per night from Oct 4 to Oct 5
    $76 total
    Oct 4 - Oct 5
    Total with taxes and fees

Southeast Missouri hotels essential information

Accommodation
686 hotels
Lowest Price
$62
Highest Price
$351
Popular hotels
Drury Plaza Hotel Cape Girardeau Conference Center, Pear Tree Inn Cape Girardeau West, Baymont Inn and Suites by Wyndham Farmington, MO, Comfort Inn Festus - St Louis South, The Riverview, Drury Inn & Suites Sikeston, MO, Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy, La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Days Inn and Suites by Wyndham Sikeston, Silo Farm Haus- located in the heart of wine country!, Holiday Inn Poplar Bluff by IHG, Hampton Inn Poplar Bluff

Recent Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

5/5 Excellent
"This hotel is in a great location just off the US 67 expressway! Easy to get in and out of the parking lot. We were 10 minutes south of the business district on either side of Walmart. Take the first left. The staff was very friendly and helpful going so far as to changing our room to the 1st floor because there wasn’t an elevator for my oxygen machine because there’s only 2 stories. Breakfast was the usual hot food buffet including the waffle maker! The AC was set to 60. We turned it up to 70 because it wasn’t that hot outside. This was a very nice basic hotel with suites."
A verified traveler stayed at Baymont Inn and Suites by Wyndham Farmington, MO
Posted 2 hours ago
Baymont Inn and Suites by Wyndham Farmington, MO

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