Santee Luxury Hotels
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Featured Santee Luxury Hotels

Red Roof Inn Santee
9091 Old Hwy 6 Santee SC
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $78 total per night
$78 total
Dec 17 - Dec 18
Total with taxes and fees
Red Roof Inn Santee features free WiFi in public areas, coffee in a common area, and express check-out. If you drive, put free parking to good use. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. This smoke-free hotel also has a vending machine.
Breakfast included
Pet friendly

Comfort Inn & Suites Santee
221 Britain St Santee SC
Free Cancellation
Reserve now, pay when you stay
$106 nightly
The price is $118 total per night
$118 total
Dec 24 - Dec 25
Total with taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included

Baymont by Wyndham Santee
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
$80 nightly
The price is $89 total per night
$89 total
Dec 17 - Dec 18
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly

Ramada by Wyndham Santee I-95
123 Mall Street Santee SC
Free Cancellation
Reserve now, pay when you stay
$73 nightly
The price is $81 total per night
$81 total
Jan 10 - Jan 11, 2026
Total with taxes and fees
Guests of Ramada by Wyndham Santee I-95 have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking, and an airport shuttle (available 24 hours) for USD 80 per room roundtrip. The 24-hour front desk has staff always at the ready. Other amenities at this golf hotel include meeting rooms, a conference center, and a 24-hour business center.
Pool
Breakfast included

Econo Lodge
9112 Old 6 Highway Santee SC
Free Cancellation
Reserve now, pay when you stay
$63 nightly
The price is $70 total per night
$70 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Econo Lodge Santee features free WiFi in public areas and barbecue grills. There's free parking if you drive. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. This hotel also has a garden.
Pet friendly
Parking included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Santee hotels essential information
Accommodation | 306 hotels |
|---|---|
Lowest Price | $70 |
Highest Price | $118 |
Popular hotels | Red Roof Inn Santee, Comfort Inn & Suites Santee, Baymont by Wyndham Santee, Ramada by Wyndham Santee I-95, Econo Lodge |
Recent Luxury Hotels Reviews

Tru By Hilton Santee
5/5 Excellent
"Clean room. Courteous staff. And a really fun vibe! "
A verified traveler stayed at Tru By Hilton Santee
Posted 23 hours ago
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