Find South Carolina Midlands Boutique Hotels
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Tomorrow night
Check prices in South Carolina Midlands for tomorrow night, Dec 25 - Dec 26Featured South Carolina Midlands Boutique Hotels

Hotel Florence, Tapestry Collection by Hilton
126 W Evans St Florence SC
Free Cancellation
Reserve now, pay when you stay
$130 nightly
The price is $146 total per night
$146 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Guests staying at Hotel Florence, Tapestry Collection by Hilton enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Other amenities at this spa hotel include meeting rooms, conference space, and a 24-hour business center.
Spa
Parking included

The Inn at the Crossroads
128 West Main Street Lake City SC
Free Cancellation
Reserve now, pay when you stay
$127 nightly
The price is $143 total per night
$143 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
The Inn at the Crossroads features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, tours or tickets, and luggage storage. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a terrace.
Breakfast included
Parking included

The Mantissa Hotel
130 East Carolina Ave Hartsville SC
Free Cancellation
Reserve now, pay when you stay
$162 nightly
The price is $181 total per night
$181 total
Dec 30 - Dec 31
Total with taxes and fees
Guests staying at The Mantissa Hotel enjoy a gym, a rooftop terrace, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a business center and a banquet hall.
Breakfast included
Parking included

Inn on the Square, an Ascend Collection Hotel
104 Court Avenue East Greenwood SC
Free Cancellation
$108 nightly
The price is $120 total per night
$120 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
Inn on the Square, an Ascend Collection Hotel features free WiFi in public areas, meeting rooms, and a conference center. A stay here includes free parking. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and concierge services. Additional amenities include coffee/tea in a common area, a terrace, and a ballroom.
Parking included
Free WiFi

Graduate by Hilton Columbia SC
1619 Pendleton Street Columbia SC
Free Cancellation
Reserve now, pay when you stay
$108 nightly
The price is $122 total per night
$122 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Graduate by Hilton Columbia SC features a 24-hour gym, free WiFi in public areas, and conference space. Self parking is offered for USD 10 per night. Front-desk staff can answer questions 24/7, and assist with luggage storage, securing valuables, and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include coffee/tea in a common area, a library, and express check-in.
Pet friendly
Free WiFi

Hyatt Place Columbia/Downtown/The Vista
819 Gervais Street Columbia SC
Free Cancellation
Reserve now, pay when you stay
$110 nightly
The price is $123 total per night
$123 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Guests of Hyatt Place Columbia/Downtown/The Vista have access to an indoor pool, a gym, and free WiFi in public areas. Valet parking is offered for USD 18.00 per day. The 24-hour front desk has staff standing by to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included

Sheraton Columbia Downtown Hotel
1400 Main St Columbia SC
Free Cancellation
Reserve now, pay when you stay
$101 nightly
The price is $113 total per night
$113 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
At Sheraton Columbia Downtown Hotel, guests have access to a 24-hour gym, free WiFi in public areas, and a business center. Valet parking is offered for USD 31.32 per night. The 24-hour front desk has staff standing by to help with securing valuables, dry cleaning/laundry, and luggage storage. Additional amenities include a computer station and express check-out.
Free WiFi
Air conditioning

Lookaway Inn
103 W Forest Ave North Augusta SC
$149 nightly
The price is $167 total per night
$167 total
Dec 27 - Dec 28
Total with taxes and fees
Guests of Lookaway Inn enjoy access to free WiFi in public areas, conference space, and coffee in a common area. Free parking is included with your stay. Additional amenities include free newspapers, a terrace, and a garden.
Breakfast included
Parking included

Quality Inn Kingstree
1610 N Longstreet St Kingstree SC
Free Cancellation
Reserve now, pay when you stay
$65 nightly
The price is $72 total per night
$72 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests of Quality Inn Kingstree North enjoy access to free WiFi in public areas, meeting rooms, and a business center. There's free parking if you drive. Staff members can answer questions about accommodations, and also provide front-desk service during limited hours. Additional amenities include express check-in, express check-out, and a picnic area.
Breakfast included
Pet friendly
Don't see what you're looking for?
See all available properties in South Carolina Midlands
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
South Carolina Midlands hotels essential information
Accommodation | 3,078 hotels |
|---|---|
Lowest Price | $72 |
Highest Price | $181 |
Popular hotels | Hotel Florence, Tapestry Collection by Hilton, The Inn at the Crossroads, The Mantissa Hotel, Inn on the Square, an Ascend Collection Hotel, Graduate by Hilton Columbia SC, Hyatt Place Columbia/Downtown/The Vista, Sheraton Columbia Downtown Hotel, Lookaway Inn, Quality Inn Kingstree |
Recent Boutique Hotels Reviews

Clarion Pointe Rock Hill Near University
5/5 Excellent
"I stayed only one night, the room was clean and the bed was comfortable "
A verified traveler stayed at Clarion Pointe Rock Hill Near University
Posted 3 days ago
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