$142 Cheap flights to Santa Cruz

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Puerto Ayora

Puerto Ayora

Cheap flights to Santa Cruz from $142 One Way, $275 Round Trip

$275 return flights and $142 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Mar 20 - Tue, Mar 23
UIO
Quito
SCY
San Cristobal
$275 Roundtrip, found 6 days ago
$275
Roundtrip
found 6 days ago
Select avianca flight, departing Sat, Mar 20 from Quito to San Cristobal, returning Tue, Mar 23, priced at $275 found 6 days ago
Mon, Mar 22 - Wed, Mar 24
GYE
Guayaquil
SCY
San Cristobal
$283 Roundtrip, found 6 days ago
$283
Roundtrip
found 6 days ago
Select avianca flight, departing Mon, Mar 22 from Guayaquil to San Cristobal, returning Wed, Mar 24, priced at $283 found 6 days ago
Thu, Apr 8 - Tue, Apr 13
UIO
Quito
GPS
Santa Cruz Island
$308 Roundtrip, found 6 days ago
$308
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, Apr 8 from Quito to Santa Cruz Island, returning Tue, Apr 13, priced at $308 found 6 days ago
Fri, Mar 5 - Mon, Mar 8
GYE
Guayaquil
GPS
Santa Cruz Island
$311 Roundtrip, found 2 hours ago
$311
Roundtrip
found 2 hours ago
Select LATAM Airlines Group flight, departing Fri, Mar 5 from Guayaquil to Santa Cruz Island, returning Mon, Mar 8, priced at $311 found 2 hours ago
Tue, Nov 17 - Tue, Nov 24
CUE
Cuenca
GPS
Santa Cruz Island
$339 Roundtrip, found 7 hours ago
$339
Roundtrip
found 7 hours ago
Select LATAM Airlines Group flight, departing Tue, Nov 17 from Cuenca to Santa Cruz Island, returning Tue, Nov 24, priced at $339 found 7 hours ago
Tue, Nov 24 - Mon, Nov 30
CUE
Cuenca
SCY
San Cristobal
$368 Roundtrip, found 12 hours ago
$368
Roundtrip
found 12 hours ago
Select avianca flight, departing Tue, Nov 24 from Cuenca to San Cristobal, returning Mon, Nov 30, priced at $368 found 12 hours ago
Thu, Nov 12 - Wed, Nov 18
FLL
Fort Lauderdale
SCY
San Cristobal
$485 Roundtrip, found 7 hours ago
$485
Roundtrip
found 7 hours ago
Select avianca flight, departing Thu, Nov 12 from Fort Lauderdale to San Cristobal, returning Wed, Nov 18, priced at $485 found 7 hours ago
Sat, Oct 24 - Sat, Oct 31
FLL
Fort Lauderdale
GPS
Santa Cruz Island
$558 Roundtrip, found 9 hours ago
$558
Roundtrip
found 9 hours ago
Select avianca flight, departing Sat, Oct 24 from Fort Lauderdale to Santa Cruz Island, returning Sat, Oct 31, priced at $558 found 9 hours ago
Sat, Mar 6 - Sun, Mar 14
BOS
Boston
SCY
San Cristobal
$589 Roundtrip, found 2 hours ago
$589
Roundtrip
found 2 hours ago
Select avianca flight, departing Sat, Mar 6 from Boston to San Cristobal, returning Sun, Mar 14, priced at $589 found 2 hours ago
Mon, Nov 30 - Sun, Dec 6
MIA
Miami
SCY
San Cristobal
$603 Roundtrip, found 2 hours ago
$603
Roundtrip
found 2 hours ago
Select avianca flight, departing Mon, Nov 30 from Miami to San Cristobal, returning Sun, Dec 6, priced at $603 found 2 hours ago
Tue, Jan 26 - Thu, Feb 4
MIA
Miami
GPS
Santa Cruz Island
$621 Roundtrip, found 2 hours ago
$621
Roundtrip
found 2 hours ago
Select avianca flight, departing Tue, Jan 26 from Miami to Santa Cruz Island, returning Thu, Feb 4, priced at $621 found 2 hours ago
Thu, Apr 1 - Fri, Apr 30
BOS
Boston
GPS
Santa Cruz Island
$624 Roundtrip, found 2 hours ago
$624
Roundtrip
found 2 hours ago
Select avianca flight, departing Thu, Apr 1 from Boston to Santa Cruz Island, returning Fri, Apr 30, priced at $624 found 2 hours ago

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
GYEPuerto Baquerizo MorenoOctober 23 to October 26$308
UIOSanta RosaOctober 25 to October 28$316
GYESanta RosaOctober 24 to October 30$329
UIOPuerto Baquerizo MorenoOctober 25 to October 27$335
LIMSanta RosaOctober 25 to October 28$661
MIAPuerto Baquerizo MorenoOctober 23 to October 28$720
JFKPuerto Baquerizo MorenoOctober 23 to October 28$721
JFKSanta RosaOctober 24 to October 30$754
MIASanta RosaOctober 23 to October 28$905
LAXSanta RosaOctober 23 to October 27$1,289
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
$129 nightly
The price is $129 total per night from Nov 19 to Nov 20
$129 total
Nov 19 - Nov 20
Stay at this hotel in Puerto Ayora. Enjoy free WiFi, 3 hot tubs, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Las ...
9/10 Wonderful! (449 reviews)
"We had a great stay. Quiet and close to everything"

Reviewed on Oct 13, 2026

Opens in a new windowHotel Fiesta
Hotel el descanso del Guia

Hotel el descanso del Guia

3.5 out of 5
Calle Delfin, Barrio el Mirador Puerto Ayora Galapagos
$73 nightly
The price is $73 total per night from Nov 3 to Nov 4
$73 total
Nov 3 - Nov 4
Book a stay at this family-friendly hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (235 reviews)
"All the staff were wonderful and very helpful. The breakfast was great and offered a good amount of food. Eric was the best and helped us navigate getting around the island. I would definitely stay at this hotel again."

Reviewed on Oct 16, 2026

Opens in a new windowHotel el descanso del Guia
Finch Bay Galapagos Hotel

Finch Bay Galapagos Hotel

4.5 out of 5
Barrio Punta Estrada Puerto Ayora Galapagos
$524 nightly
The price is $580 total per night from Oct 25 to Oct 26
$580 total
Oct 25 - Oct 26
Book a stay at this luxury hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and a full-service spa. Popular attractions Playa de los Alemanes and Malecon ...
9.4/10 Exceptional! (105 reviews)
"המלון הכי טוב בגלאפגוס רמה גבוהה מאוד שירות מדהים קצת יקר אבל שווה את המחיר מומלץ מאוד"

Reviewed on Oct 14, 2026

Opens in a new windowFinch Bay Galapagos Hotel
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Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
$117 nightly
The price is $117 total per night from Oct 31 to Nov 1
$117 total
Oct 31 - Nov 1
Book a stay at this family-friendly hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the breakfast and the helpful ...
Opens in a new windowMaidith Galapagos Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass
  • 5 people
Jeep Compass
SUV Jeep Compass

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.