$153 Cheap flights to Santa Cruz

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Top places to visit in Santa Cruz

Cheap flights to Santa Cruz from $153 One Way, $308 Round Trip

$308 return flights and $153 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
GYEPuerto Baquerizo MorenoJune 26 to July 18$319
UIOPuerto Baquerizo MorenoJune 28 to July 1$348
GYESanta RosaJune 28 to July 3$434
UIOSanta RosaJune 28 to July 3$456
MIASanta RosaJune 26 to June 30$674
MIAPuerto Baquerizo MorenoJune 26 to June 29$687
IAHPuerto Baquerizo MorenoJune 27 to July 3$1,131
JFKPuerto Baquerizo MorenoJune 26 to June 30$1,156
IAHSanta RosaJune 27 to July 1$1,214
JFKSanta RosaJune 26 to July 3$1,339
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo Puerto Ayora Galapagos
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $152 total per night from Jun 24 to Jun 25
$152 total
Jun 24 - Jun 25
Stay at this hotel in Puerto Ayora. Enjoy free WiFi, 3 hot tubs, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Tortuga ...
9/10 Wonderful! (416 reviews)
"We had an excellent stay at Hotel Fiesta. Vanessa and Gabriel at the front desk were exceptional. They were always willing to help with anything we needed, in a professional, friendly, and welcoming manner. They truly made our experience even better. The hotel is beautiful and very well located, ..."

Reviewed on Jun 23, 2026

Opens in a new windowHotel Fiesta
Hotel el descanso del Guia

Hotel el descanso del Guia

3.5 out of 5
Calle Delfin, Barrio el Mirador Puerto Ayora Galapagos
$78 nightly
The price is $78 total per night from Jun 24 to Jun 25
$78 total
Jun 24 - Jun 25
Book a stay at this family-friendly hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (212 reviews)
"We dropped our baggage and left for another island Staff was extremely helpful Hotel is not responsible for power outages but the n the few days we were there .. yes we had power outages"

Reviewed on Jun 22, 2026

Opens in a new windowHotel el descanso del Guia
Finch Bay Galapagos Hotel

Finch Bay Galapagos Hotel

4.5 out of 5
Barrio Punta Estrada Puerto Ayora Galapagos
$522 nightly
The price is $579 total per night from Jun 24 to Jun 25
$579 total
Jun 24 - Jun 25
Book a stay at this luxury hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and a full-service spa. Popular attractions Tortuga Bay Beach and Playa de ...
9.4/10 Exceptional! (100 reviews)
"Highly recomended"

Reviewed on May 1, 2026

Opens in a new windowFinch Bay Galapagos Hotel
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Maidith Galapagos Inn

Maidith Galapagos Inn

3 out of 5
Calle Cucuve #341 y Seymour, Santa Cruz Puerto Ayora Galápagos
$126 nightly
The price is $126 total per night from Jun 24 to Jun 25
$126 total
Jun 24 - Jun 25
Book a stay at this family-friendly hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the breakfast and the helpful ...
10/10 Exceptional! (145 reviews)
"Good breakfast"

Reviewed on Jun 12, 2026

Opens in a new windowMaidith Galapagos Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Santa Cruz

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.