$74 Cheap flights to Florence County

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Top places to visit in Florence County

A historic brick building with arched windows and a river in the foreground.
FlightsFlights
FlightsFlights

Florence

Florence
A sunset over a forested landscape with a river and a parking lot.
FlightsFlights
FlightsFlights

Lake City

Lake City

Cheap flights to Florence County from $74 One Way, $167 Round Trip

$167 return flights and $74 one-way flights to Florence County were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Mar 29 - Fri, Apr 2
LCK
Columbus
MYR
Myrtle Beach
$167 Roundtrip, found 8 hours ago
$167
Roundtrip
found 8 hours ago
Select Allegiant Air flight, departing Mon, Mar 29 from Columbus to Myrtle Beach, returning Fri, Apr 2, priced at $167 found 8 hours ago
Mon, Oct 5 - Fri, Oct 9
LCK
Columbus
MYR
Myrtle Beach
$201 Roundtrip, found 4 hours ago
$201
Roundtrip
found 4 hours ago
Select Allegiant Air flight, departing Mon, Oct 5 from Columbus to Myrtle Beach, returning Fri, Oct 9, priced at $201 found 4 hours ago
Wed, Oct 28 - Sat, Oct 31
MSP
Minneapolis
MYR
Myrtle Beach
$217 Roundtrip, found 6 days ago
$217
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Oct 28 from Minneapolis to Myrtle Beach, returning Sat, Oct 31, priced at $217 found 6 days ago
Wed, Oct 28 - Sat, Oct 31
MSP
Minneapolis
MYR
Myrtle Beach
$217 Roundtrip, found 6 days ago
$217
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Wed, Oct 28 from Minneapolis to Myrtle Beach, returning Sat, Oct 31, priced at $217 found 6 days ago
Sat, Oct 17 - Tue, Oct 20
CMH
Columbus
MYR
Myrtle Beach
$221 Roundtrip, found 6 days ago
$221
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 17 from Columbus to Myrtle Beach, returning Tue, Oct 20, priced at $221 found 6 days ago
Sat, Oct 17 - Tue, Oct 20
CMH
Columbus
MYR
Myrtle Beach
$221 Roundtrip, found 6 days ago
$221
Roundtrip
found 6 days ago
Select Delta flight, departing Sat, Oct 17 from Columbus to Myrtle Beach, returning Tue, Oct 20, priced at $221 found 6 days ago

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
TPAMyrtle BeachSeptember 26 to September 26$181
FLLMyrtle BeachSeptember 26 to September 28$183
SWFMyrtle BeachSeptember 27 to October 2$244
DENMyrtle BeachSeptember 25 to October 10$371
BOSMyrtle BeachSeptember 26 to October 3$383
ALBMyrtle BeachSeptember 25 to September 28$402
EWRMyrtle BeachSeptember 25 to September 29$411
LGAMyrtle BeachSeptember 25 to September 25$615
MSPMyrtle BeachSeptember 26 to October 3$890
JFKFlorenceSeptember 27 to September 30$891
DFWMyrtle BeachSeptember 26 to September 27$1,337
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Florence County Accommodation Deals

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Fully refundable
$89 nightly
The price is $100 total per night from Oct 4 to Oct 5
$100 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Opens in a new windowPark Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $72 total per night from Sep 23 to Sep 24
$72 total
Sep 23 - Sep 24
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Opens in a new windowHoward Johnson by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Oct 4 to Oct 5
$100 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (376 reviews)
"The room and bathroom were clean. Bed was comfy and the room had everything needed. I didn't realize that room access was from the outside but I didn't pay attention when I booked the room so that's on me. Breakfast was good and everything was neat and clean . The AC in my room only worked correctly ..."

Reviewed on Sep 19, 2026

Opens in a new windowQuality Inn & Suites Florence Civic Center
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Fully refundable
$101 nightly
The price is $113 total per night from Oct 18 to Oct 19
$113 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,366 reviews)
"Room was very clean and comfortable. Breakfast was as expected with the usual waffles, yogurt, scrambled eggs and sausage. We enjoyed our stay. Staff very friendly and helpful."

Reviewed on Sep 21, 2026

Opens in a new windowComfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass
  • 5 people
Jeep Compass
SUV Jeep Compass

Florence County

Are you in the mood for a cruise? Shop Orbitz today for cheap cruises and flights to Florence County. Our award-winning cruise site features exclusive offers, information for first-timers and top destinations and activities. Make discount domestic and international travel plans in an instant with cutting-edge mobile tools from Orbitz.

Top Pick

Orbitz holds a “Best of the Web” Cruise Site Award from Forbes Magazine. You won’t find better deals anywhere on low cost cruises and low fare Florence County flights. Our Customer Care and guaranteed low prices make Orbitz the team to beat in budget cruises and air ticket sales.

Exclusive Offers

Register for Orbitz email updates and our cruise experts will notify you of bargain tickets on cruises as they’re posted. Install our free mobile apps on your iPad, iPhone or Android for easy booking and mobile-only savings on flights to Florence County. Visit www.Orbitz.com to learn more about these amazing benefits and our 110% Best Price Guarantee.

First-Timers

Are you and your family cruise newbies? Orbitz offers Cruising 101 and Cruise FAQ to answer any questions you may have. Book your cruise and air travel with Orbitz On the Go for greater savings on Florence County flights.

Ports and Play

Be sure to check our cruise page for free shore excursions, onboard spending, balcony upgrades and other perks. Orbitz offers last-minute, luxury, weekend and summer cruises. You can even designate which port you want to sail from and pre-book on-shore activities. Get there on the cheap with discounts on flights to Florence County and Florence County flights. Get more bang for your travel buck at Orbitz.

Frequently asked questions

What is the best airport to fly to in Florence County?
There's one main entry point for this region — Florence Regional Airport (FLO). Book your flights to this popular gateway and see all that Florence County has to offer.
How much is a flight to Florence County?
Round-trip prices dropped as low as $167 this week to Florence County, and reached a high of $1,337. Passengers flying out of Columbus (LCK) managed to land one-way flights from just $74.
How to book the cheapest flight to Florence County?
Snapping up cheap flights to Florence County is as simple as booking your ticket with Orbitz. But if you'd love to make sure you're nabbing the best flight deals around, here are a few tips worth following:

  • Depending on your place of departure, choose the 'Nearby airports' function (located under the departure and arrival options). At times, other departure points will have cheaper fares.
  • Also, click on the 'Show flexible dates' link to view the prices for days around your chosen departure. You may be able to pick up cheaper flight deals if you're flexible with your schedule.
  • You can also use the 'Show options' link to filter results for your preferred carrier, seating class, nonstop flights and refundable flights. Under 'Sort & Filter' to the left, you can even choose the time of day you want to fly.
  • Once you've sorted out your travel dates, don't delay booking. Prices generally increase as the departure date nears.
  • Think about bundling your hotels, flights and car rental into an Orbitz package — the more you book, the more you save.
  • Flying during busier seasons means steep airfares. If possible, plan your trip outside of popular periods, such as Thanksgiving, New Year's Eve and Easter.

What is the best time to book a flight to Florence County?
Generally speaking, January is the cheapest time to purchase your plane ticket. This is closely followed by February and August. Bear this in mind while you search for a cheap flight to Florence County.
What day of the week is the cheapest to book a flight to Florence County?
If you're after inexpensive fares to Florence County, the best days to make a booking are Tuesdays, Wednesdays and Saturdays. With Orbitz (and some good timing!), an unbeatable flight deal will be all yours.
What is the cheapest day of the week to fly to Florence County?
Based on Orbitz data from 2020, Monday tends to be the best day to nab cheap flights to Florence County. Tuesday also offers budget-friendly airfares, whereas Saturday has the most expensive ticket prices. Although flying out at the weekend can be more suitable, you'll have more money in your pocket to play with if you jet out early in the week.
What is the cheapest month to fly to Florence County?
If you're flexible with your travel dates, consider leaving during August. Orbitz data shows that this is generally the best month to take off if you're looking for cheap flights to Florence County. As you would imagine, fares get pricier in June and flights book out quickly.
Which airlines allow free cancellation?
Life changes, and we believe your ticket should be able to do the same. That's why Orbitz makes it a snap to search for airlines with free cancellation and no change fees. Just enter your departure and arrival points and then select "Filter by flexible change policies." How's that for peace of mind?
What do I need for the flight to Florence County?
Whether you're accustomed to flying or you're new to the skies, it's always great to be prepared when you travel. Here are several tips and things to take into consideration:

  • Make sure you've packed your travel documents and identification. For overseas trips, you'll need your passport. When booking your seats, always use the same name, birth date and gender as listed on your current ID.
  • Pack your carry-on bag with snacks and things to keep you busy and watch time whiz by on this medium-haul flight. Wherever possible, hop on the airport's Wi-Fi and transfer your favorite playlist or podcast to your phone or tablet before take off.
  • Never mind what the season is, airplane cabins are often quite cold. Bring a sweater with you on your journey to stay cozy and warm.

How do I get cheap first-class/business deals to Florence County?
There are ways of booking first or business-class airfares to Florence County that won't burn through your budget. Pick up a seat at the front of the plane for less with these useful tips:

  • Be flexible with your travel dates and wait for huge sales on business or first-class airfares.
  • Budget airlines offer business-class seating at a fraction of the usual price. Ditch the full-service carriers and fly with one these cheaper options.
  • Make a bid for an upgrade. Some carriers hold online auctions that let you offer a price for a seat at the front of the plane. You may also be able to upgrade with points earned through a loyalty program.

What is the best time to go to Florence County?
If you'd like to experience Florence County in the peak season, March, April and July are the top months to visit. June 20 marks the onset of summer in the Northern Hemisphere and is an awesome time to travel if you love being outside. During this time of the year, average daily temperatures generally range from 70 ºF to 90 ºF.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.