Beginning of main content

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Featured Vacation Homes in Panama City

Great Value IN A Resort Community! Open 4/18-25! Sleeps UP TO 7!
Great Value IN A Resort Community! Open 4/18-25! Sleeps UP TO 7!
Panama City Beach, FL
Guests of this resort have access to a spa tub.
Beach Studio Studio Bedroom Home
Beach Studio Studio Bedroom Home
3.0 out of 5.0 9815 Beach Blvd, Unit 2, Panama City Beach, FL
At this vacation home, guests enjoy an outdoor pool, a fitness center, and a spa tub. A stay here includes free offsite parking.
Endless Summer Units
Endless Summer Units
3.5 out of 5.0 17614 Front Beach Road #A-26, Panama City Beach, FL
At Endless Summer Units, guests have access to free WiFi in public areas. Staff members can help with accommodation requests, and provide front-desk service ...
The Summit 325
The Summit 325
3.5 out of 5.0 8743 Thomas Drive, 325, Panama City Beach, FL
$161
Guests of this vacation home have access to an outdoor pool, a fitness center, and a spa tub. Onsite parking is offered for a fee. Other amenities at this golf ...
Relaxing Beach Resort Town Home-close to Everything
Relaxing Beach Resort Town Home-close to Everything
Panama City Beach, FL
A fitness center and an outdoor tennis court are features at this resort.
Moondrifter 501
Moondrifter 501
3.5 out of 5.0 8815 Thomas Drive, 501, Panama City Beach, FL
$213
Guests of this vacation home enjoy features like an outdoor pool, an outdoor tennis court, and a terrace. Onsite parking is available for a fee. Other amenities ...
No Management Fees!! Budget Friendly. 3 Minute Walk to Beach
No Management Fees!! Budget Friendly. 3 Minute Walk to Beach
Panama City Beach, FL
Guests staying at this resort enjoy a water park, an outdoor tennis court, and a garden.
? Start "making Memories" Beautiful Pet Friendly Home Away From Home ?
? Start "making Memories" Beautiful Pet Friendly Home Away From Home ?
Panama City Beach, FL
At this vacation home, guests have access to a garden.
Premier Townhomes by Panhandle Getaways
Premier Townhomes by Panhandle Getaways
3.0 out of 5.0 17195 Front Beach Rd, Panama City Beach, FL
$265
At this vacation home, guests have access to free WiFi in public areas and a terrace. There's free parking and an airport shuttle for a fee.
Map

Panama City Vacation Homes

Book vacation homes in Panama City
Next time you take a group getaway top Panama City, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Panama City vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Panama City vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Panama City; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Panama City rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Panama City is sure to be a winner.

Hotel Options in Panama City

See all 6,480 Properties in Panama City
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.