Package deals near Mississippi River
Save more on your trip when booking your flight + hotel together
Top Mississippi River vacation deals
Hilton New Orleans Riverside
Jun 29 - Jul 3
Boston (BOS) to New Orleans (MSY)
New Orleans (MSY) to Boston (BOS)
Reviewed on Apr 25, 2026
The Wildwood Hotel
Jul 8 - Jul 11
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
Reviewed on Feb 24, 2026
Hotel Riu Plaza Chicago
Jul 24 - Jul 27
Boston (BOS) to Chicago (ORD)
Reviewed on Mar 8, 2026
Swissotel - Chicago
Jul 24 - Jul 27
Boston (BOS) to Chicago (ORD)
Reviewed on Apr 21, 2026
Hotel Felix River North/Magnificent Mile
Jul 29 - Aug 3
Boston (BOS) to Chicago (ORD)
Reviewed on May 2, 2026
Level Chicago Fulton Market
Jul 22 - Jul 26
Boston (BOS) to Chicago (ORD)
Chicago (ORD) to Boston (BOS)
Hotel deals near Mississippi River
Hyatt Regency St. Louis at The Arch
Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Book a Mississippi River vacation package
Stop dreaming and start traveling. If you’ve always wanted to see Mississippi River, now is the perfect time. Book your getaway to with Orbitz and get ready to tick this attraction off your bucket list. Plus when you lock in your package with us, you’ll have plenty of cash leftover to splash out on other amazing sights. Because travel is all about investing in experiences, not things!
If you’re hoping to stay close to Mississippi River, we’ve got you covered. Choose from a great range of hotels not far from this attraction. Roll out of bed, slip on your walking shoes and you’ll be there within moments. What could be more convenient than that? You won’t just be close to all the action — you’ll save money on transportation, and a hot shower and cozy bed will be within reach after a big day of exploring. Now that’s what we call a stress- free, full-of-fun getaway.
Orbitz has your ticket to a rewarding Mississippi River vacation. Book your package with us and you’ll be able to access Orbitz Rewards. Earn Orbucks when you reserve your flights, hotels and activities with Orbitz and redeem them at over 385,000 hotels worldwide. $1 Orbuck = $1 off your next hotel. Join, earn, redeem — just like that! When you join Orbitz Rewards, you’ll also instantly unlock exclusive deals and save on thousands of properties with Insider Pricing.
We believe the best reward that you can give to yourself or others is the gift of travel. So, don’t put off exploring Mississippi River any longer. Save a bundle and book your escape with Orbitz today.
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^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from 2019-04-01 - 2020-03-31 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.