Package deals near Mississippi River

Save more on your trip when booking your flight + hotel together

Top Mississippi River vacation deals

Price found within the past 48 hours. Click for updated prices.
Hilton Grand Vacations Club Chicago Magnificent Mile
3.5-star property

Hilton Grand Vacations Club Chicago Magnificent Mile

Downtown Chicago
9.2/10 Wonderful! (317 reviews)

Mar 20 - Mar 22

2 night stay

Newark Liberty Intl. Airport (EWR) to Chicago (ORD)

American Airlines • Coach

Chicago (ORD) to Newark Liberty Intl. Airport (EWR)

Spirit Airlines • Coach
Save 100% on your flight
Price was $607, price is now $376 per person
$376
per person
found 1 day ago
close to everything we will be staying here again on our next vacation to Chicago

Reviewed on Aug 31, 2024

Hotel Riu Plaza Chicago
4.0-star property

Hotel Riu Plaza Chicago

Downtown Chicago
9.4/10 Exceptional! (2,790 reviews)

Apr 2 - Apr 5

3 night stay

Newark Liberty Intl. Airport (EWR) to Chicago (ORD)

Spirit Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $826, price is now $450 per person
$450
per person
found 1 day ago
I recommend 100% Everything was good, the staff, room and the food. Also, it is located in a good area.

Reviewed on Jan 14, 2026

Waldorf Astoria Chicago
5.0-star property

Waldorf Astoria Chicago

Downtown Chicago
9.4/10 Exceptional! (1,000 reviews)

Apr 5 - Apr 10

5 night stay

Newark Liberty Intl. Airport (EWR) to Chicago (ORD)

Spirit Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $1,786, price is now $1,017 per person
$1,017
per person
found 12 hours ago
Lovely room and spacious bathroom plus all of the high end touches (robes, slippers to soft mats and towels and great bath products and loved the nespresso maker!) View was not great but gym and lobby made up for it; bar was too crowded and we couldn’t get a late checkout but at least it was noon and they held our bags for a few hours!

Reviewed on Dec 31, 2025

theWit Chicago, a Hilton Hotel
4.5-star property

theWit Chicago, a Hilton Hotel

Downtown Chicago
9/10 Wonderful! (1,001 reviews)

Apr 2 - Apr 5

3 night stay

Newark Liberty Intl. Airport (EWR) to Chicago (ORD)

Spirit Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $705, price is now $422 per person
$422
per person
found 1 day ago
It's really a problem that the elevators are prioritized for people going to the rooftop vs guests of the hotel. We had to wait as several elevators took people to the rooftop while guests were standing there waiting on an elevator. Really disappointing.

Reviewed on Aug 4, 2025

The Wildwood Hotel
3.5-star property

The Wildwood Hotel

9.2/10 Wonderful! (1,600 reviews)

Apr 5 - Apr 9

4 night stay

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

United • Coach

St. Louis (STL) to Newark Liberty Intl. Airport (EWR)

Frontier Airlines • Coach
Price was $743, price is now $475 per person
$475
per person
found 13 hours ago
This hotel was fantastic! Check in was easy with friendly staff, the room was beautiful and well appointed. Breakfast was advertised as a Continental, however they had hot options as well, which was great. Every staff member we saw in the hotel said hi and was friendly. I would definitely stay here again!

Reviewed on Oct 16, 2025

The Langham, Chicago
5.0-star property

The Langham, Chicago

Downtown Chicago
9.8/10 Exceptional! (1,001 reviews)

Mar 23 - Mar 26

3 night stay

Minneapolis (MSP) to Chicago (ORD)

Delta • Coach

Chicago (ORD) to Minneapolis (MSP)

Southwest Airlines • Coach
Save 100% on your flight
Price was $937, price is now $603 per person
$603
per person
found 6 hours ago
Just an absolutely beautiful hotel with spectacular service. Highly recommend.

Reviewed on Mar 29, 2024

Hotel deals near Mississippi River

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln St. Ann MO
Free Cancellation
Reserve now, pay when you stay
69.84 mi from Mississippi River
$90 nightly
The price is $106 total per night
$106 total
Jan 24 - Jan 25
Total with taxes and fees
Pear Tree Inn St. Louis Airport features a gym, free WiFi in public areas, and conference space. You can take advantage of free parking, along with a free airport shuttle (available on request). Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a business center, a seasonal outdoor pool, and coffee/tea in a common area.
Pool
Breakfast included
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Free Cancellation
Reserve now, pay when you stay
75.98 mi from Mississippi River
$90 nightly
The price is $105 total per night
$105 total
Jan 30 - Jan 31
Total with taxes and fees
Guests of Clayton Plaza Hotel & Extended Stay have access to an indoor pool, a 24-hour gym, and a sauna. Self parking is offered for USD 6.00 per night. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and conference space.
Pool
Breakfast included
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Free Cancellation
Reserve now, pay when you stay
81.27 mi from Mississippi River
$148 nightly
The price is $173 total per night
$173 total
Feb 9 - Feb 10
Total with taxes and fees
Guests of 21C Museum Hotel St Louis have access to an indoor pool, a gym, and a steam room. Valet parking is offered for USD 50 per day. The front desk is staffed 24/7 to help with concierge services, dry cleaning/laundry, and luggage storage. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a business center.
Pool
Spa
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book a Mississippi River vacation package

Stop dreaming and start traveling. If you’ve always wanted to see Mississippi River, now is the perfect time. Book your getaway to with Orbitz and get ready to tick this attraction off your bucket list. Plus when you lock in your package with us, you’ll have plenty of cash leftover to splash out on other amazing  sights. Because travel is all about investing in experiences, not things!

If you’re hoping to stay close to Mississippi River, we’ve got you covered. Choose from a great range of hotels not far from this attraction. Roll out of bed, slip on your walking shoes and you’ll be there within moments. What could be more convenient than that? You won’t just be close to all the action — you’ll save money on transportation, and a hot shower and cozy bed will be within reach after a big day of exploring. Now that’s what we call a stress- free, full-of-fun getaway.

Orbitz has your ticket to a rewarding Mississippi River vacation. Book your  package with us and you’ll be able to access Orbitz Rewards. Earn Orbucks when you reserve your flights, hotels and activities with Orbitz and redeem them at over 385,000 hotels worldwide. $1 Orbuck = $1 off your next hotel. Join, earn, redeem — just like that! When you join Orbitz Rewards, you’ll also instantly unlock exclusive deals and save on thousands of properties with Insider Pricing.

We believe the best reward that you can give to yourself or others is the gift of travel. So, don’t put off exploring Mississippi River any longer. Save a bundle and book your  escape with Orbitz today.

^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from 2019-04-01 - 2020-03-31 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.