Package deals near Mississippi River
Save more on your trip when booking your flight + hotel together
Top Mississippi River vacation deals
Hotel Riu Plaza Chicago
Oct 9 - Oct 11
Boston (BOS) to Chicago (ORD)
Reviewed on Sep 3, 2026
The Talbott, Autograph Collection
Nov 5 - Nov 9
Boston (BOS) to Chicago (ORD)
Reviewed on Sep 2, 2026
Four Seasons Hotel Minneapolis
Nov 7 - Nov 10
Chicago (ORD) to Minneapolis (MSP)
Reviewed on Aug 30, 2026
The Maidstone New Orleans
Oct 27 - Nov 3
Boston (BOS) to New Orleans (MSY)
New Orleans (MSY) to Boston (BOS)
Reviewed on Jun 1, 2026
The Wheeler Mansion
Oct 15 - Oct 19
Fort Lauderdale (FLL) to Chicago (ORD)
Reviewed on Sep 3, 2026
Hotel deals near Mississippi River
Renaissance St. Louis Airport Hotel
Clayton Plaza Hotel & Extended Stay
Pear Tree Inn St. Louis Airport
Book a Mississippi River vacation package
Stop dreaming and start traveling. If you’ve always wanted to see Mississippi River, now is the perfect time. Book your getaway to with Orbitz and get ready to tick this attraction off your bucket list. Plus when you lock in your package with us, you’ll have plenty of cash leftover to splash out on other amazing sights. Because travel is all about investing in experiences, not things!
If you’re hoping to stay close to Mississippi River, we’ve got you covered. Choose from a great range of hotels not far from this attraction. Roll out of bed, slip on your walking shoes and you’ll be there within moments. What could be more convenient than that? You won’t just be close to all the action — you’ll save money on transportation, and a hot shower and cozy bed will be within reach after a big day of exploring. Now that’s what we call a stress- free, full-of-fun getaway.
Orbitz has your ticket to a rewarding Mississippi River vacation. Book your package with us and you’ll be able to access Orbitz Rewards. Earn Orbucks when you reserve your flights, hotels and activities with Orbitz and redeem them at over 385,000 hotels worldwide. $1 Orbuck = $1 off your next hotel. Join, earn, redeem — just like that! When you join Orbitz Rewards, you’ll also instantly unlock exclusive deals and save on thousands of properties with Insider Pricing.
We believe the best reward that you can give to yourself or others is the gift of travel. So, don’t put off exploring Mississippi River any longer. Save a bundle and book your escape with Orbitz today.
- Walt Disney World® Resort
- Disneyland® Resort
- Universal Studios Florida
- Universal Studios Hollywood
- Times Square
- Universal Orlando Resort
- Waikiki Beach
- Disney SpringsTM
- Glacier National Park
- Grand Teton National Park
- LEGOLAND® California
- Port Everglades
- Magic Kingdom® Park
- Zion National Park
- Acadia National Park
- Fort Lauderdale Beach
- Great Smoky Mountains National Park
- Las Vegas Convention Center
- Disney's Animal Kingdom® Theme Park
- Seattle Cruise Ship Terminal 91
Top Trending
- Beach Resorts & Hotels in Destin
- Hotels near Pymatuning State Park
- Hotels near Heavenly Ski Resort
- Oceanfront Hotels in Virginia Beach
- Hotels in Land Between the Lakes National Recreation Area
- Hotels near John Pennekamp Coral Reef State Park
- Hotels near Great Smoky Mountains National Park
- Hotels near Carowinds Theme Park
- Hotels in Myrtle Beach
- Hotels in Atlantic City
- Hotels in Assateague Island National Seashore
- Hotels in New York
- Hotels in San Francisco
- Kid Friendly Hotels in Assateague Island National Seashore
- Hotels in New Orleans
- Hotels in Bighorn Canyon National Recreation Area
- Hotels in Las Vegas
- Hotels near Channel Islands National Park
^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from 2019-04-01 - 2020-03-31 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.