Seneca Vacation Packages

Get set to craft your dream Seneca adventure. Sit back and let the brilliant team at Orbitz find amazing flight and hotel combos for you. It's simple to save by bundling your bookings. Choose your preferred airfares, hotels, rental cars and experiences and you could save up to $374! And remember — you have loads of flexibility. Customize your trip with 500 partner airlines and some 500,000 accommodation options globally. There are endless available options to create your own incredible vacation, whatever your interests, budget or needs.

Where is Seneca?

Wondering where Seneca is? It's a neighborhood of Anderson. You'll discover it 20 miles northwest of the downtown area. Anderson is home to some 27,000 local residents.

Places to Visit in Seneca

How about some cycling? It's one of the best things to do in the Anderson region and a terrific excuse to head outdoors. Shore fishing is another activity to put on your itinerary.

Car Rentals in Seneca

Hi-ya, globetrotter. We know you want to get the most out of your vacation, so why not check out car rentals in Seneca? Book with Orbitz and get your adventure on the road today! If you're arriving at Anderson County Regional Airport and want to get your hands on a car fast, look up Enterprise. You'll find it at 4112 Clemson Blvd, 19 miles from the terminal. If you're planning on staying around the city, stop by Enterprise at 204 By Pass 123. It is situated just 1 mile from the center of town.

Places to Visit in Seneca

How about some cycling? It's one of the best things to do in the Anderson region and a terrific excuse to head outdoors. Shore fishing is another activity to put on your itinerary.

Nearest Airports to Seneca

Arriving by air? You'll be taking in the attractions of Anderson in no time! Situated 45 miles east of Seneca, Greenville-Spartanburg International Airport (GSP) is the closest terminal.

Popular Places to Visit Near Seneca

Why not visit Clemson? It is around 8 miles away.

No Cancellation Fees

Having to cancel a booking can often be a bother — but not with us! We won't impose a fee, which makes the process a cinch.^ Hotels and airlines can have the same policy, so it's a wise idea to contact them.

Top Seneca vacation package deals

Price found within the past 48 hours. Click for updated prices.

2.0-star property

Days Inn by Wyndham Seneca / Clemson Area

6.8/10 (688 reviews)

Oct 30 - Nov 2

3 night stay

New York (LGA) to Greenville (GSP)

American Airlines • Roundtrip • Coach

per person

found 21 hours ago

The beds are extremely comfortable! The room was clean for what it was. The room smelled musty and of cigarette smoke. There were water stains on the ceiling, and everything looked extremely dated despite an obvious bathroom facelift. She's no show pony, but for the price it will do for a decent night's sleep. With a little loving the place could be a gem.

Reviewed on Nov 20, 2023