Cape Girardeau Luxury Hotels
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Featured Cape Girardeau Luxury Hotels

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
Guests of this apartment enjoy access to a water park, laundry facilities, and barbecue grills.

Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Dec 22 - Dec 23
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau Near the Medical Center enjoy free WiFi in public areas, coffee in a common area, and express check-out. Front-desk staff are standing by 24/7 to assist with any requests. This smoke-free hotel also has a TV in a common area.

Quality Inn
2011 North Kingshighway Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$60 nightly
The price is $67 total per night
$67 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Guests of Quality Inn Cape Girardeau North enjoy features like an outdoor pool, free WiFi in public areas, and a computer station. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready. Additional amenities include laundry facilities, a vending machine, and a TV in a common area.
Pool
Breakfast included

Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Dec 22 - Dec 23
Total with taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a hot tub, meeting rooms, and a business center.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cape Girardeau hotels essential information
Accommodation | 172 hotels |
|---|---|
Lowest Price | $67 |
Highest Price | $102 |
Popular hotels | Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Quality Inn, Drury Inn & Suites Cape Girardeau |
Recent Luxury Hotels Reviews

Candlewood Suites Cape Girardeau by IHG
5/5 Excellent
"Room was clean and spacious."
A verified traveler stayed at Candlewood Suites Cape Girardeau by IHG
Posted 3 days ago
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