Book 4 Star Hotels in Santee

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Dec 25 - Dec 26
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Dec 26 - Dec 27
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Featured Santee 4 Stars Hotels

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Free Cancellation
Reserve now, pay when you stay
0.26 mi from city center
$103 nightly
The price is $114 total per night
$114 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Tru By Hilton Santee, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. This hotel also has a 24-hour business center.
Pool
Breakfast included
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Free Cancellation
Reserve now, pay when you stay
0.26 mi from city center
$75 nightly
The price is $83 total per night
$83 total
Dec 28 - Dec 29
Total with taxes and fees
At Baymont by Wyndham Santee, guests have access to free WiFi in public areas, coffee in a common area, and express check-in. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help with concierge services, and answer any questions about the area. Additional amenities include express check-out and a vending machine.
Breakfast included
Pet friendly
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy Santee SC
0.62 mi from city center
$121 nightly
The price is $134 total per night
$134 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests staying at Fairfield Inn & Suites by Marriott Santee enjoy an outdoor pool, a gym, and free WiFi in public areas. You can put free parking to good use if you drive. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, luggage storage, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Breakfast included
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.59 mi from city center
$133 nightly
The price is $148 total per night
$148 total
Jan 22 - Jan 23, 2026
Total with taxes and fees
At Hampton Inn Santee-I-95, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Free Cancellation
Reserve now, pay when you stay
0.17 mi from city center
$103 nightly
The price is $114 total per night
$114 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Renovated in 2023, Comfort Inn & Suites Santee offers a gym, free WiFi in public areas, and a business center. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to help secure valuables, and answer any questions about the area. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a computer station.
Pool
Breakfast included
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
Free Cancellation
0.17 mi from city center
$104 nightly
The price is $115 total per night
$115 total
Dec 28 - Dec 29
Total with taxes and fees
At Holiday Inn Santee by IHG, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Other amenities at this golf hotel include meeting rooms, conference space, and a business center.
Pool
Pet friendly
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Free Cancellation
Reserve now, pay when you stay
0.56 mi from city center
$118 nightly
The price is $131 total per night
$131 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Guests staying at Best Western Plus Santee Inn enjoy an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff always at the ready. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include conference space, a business center, and free newspapers.
Pool
Breakfast included
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
8929 Old Number Six Highway Santee SC
Free Cancellation
Reserve now, pay when you stay
0.14 mi from city center
$59 nightly
The price is $66 total per night
$66 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Quality Inn & Suites Santee I-95 features free WiFi in public areas, a seasonal outdoor pool, and microwave in a common area. If you drive, put free parking to good use. The 24-hour front desk has multilingual staff ready to assist with sightseeing, directions, and local dining recommendations. Additional amenities include a refrigerator in a common area, a computer station, and laundry facilities.
Pool
Breakfast included
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Free Cancellation
Reserve now, pay when you stay
0.73 mi from city center
$61 nightly
The price is $68 total per night
$68 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Travelodge by Wyndham Santee features free WiFi in public areas, a business center, and coffee in a common area. Free parking is available if you drive. The 24-hour front desk has staff standing by to help with securing valuables and tours/tickets. Additional amenities include an ATM and a vending machine.
Breakfast included
Pet friendly
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find 4 star hotels in Santee

A good hotel meets your expectations, but a great hotel exceeds them. A true 4 star hotel definition includes things like big, comfy beds, stylish décor and friendly service. At Orbitz, we understand that your choice in hotel can make or break an experience, and we are here to help you find the best 4 star hotels for your time in Santee. 

What's the difference between a 4 and 5 star hotel?
The difference comes down to level of luxury. While 4 star hotels offer excellent service and quality products, most 5 star hotels will feature complimentary services that go above and beyond, like gourmet dining, luxury spa experiences and poolside service. With 4 star hotels, you’ll find the most comfort without splurging on extras you may not need.

What should I look for in a 4 star hotel?
Santee 4 star hotels are likely to include things like:

  • Pool and fitness center
  • Valet parking
  • Room service
  • Dedicated concierge
  • Pillow top mattresses
  • Minibar
  • Bathrobes and bath products
  • Artwork

How do I find the best 4 star hotel?
Orbitz makes finding the best 4 star hotel in Santee simple:

  • Pick your price: You’ll find room rates ranging from $66 to $148
  • Get the best quality: 4 star hotels in Santee have an average rating of 0.0
  • Read the reviews: Read through reviews to help you choose the hotel that has everything you want

Santee hotels essential information

Accommodation
305 hotels
Lowest Price
$66
Highest Price
$148
Popular hotels
Tru By Hilton Santee, Baymont by Wyndham Santee, Fairfield Inn & Suites by Marriott Santee, Hampton Inn Santee-I-95, Comfort Inn & Suites Santee, Holiday Inn Santee by IHG, Best Western Plus Santee Inn, Quality Inn & Suites, Travelodge by Wyndham Santee

Recent Reviews

Tru By Hilton Santee

Tru By Hilton Santee

5/5 Excellent
" the rooms are clean. The bed was comfortable. I liked the way they supply shampoo and conditioner and such in each room. Showers were nice and clean plenty of towels. Water pressure was good. Enjoyed our stay. We always try to stay at a true when traveling."
A verified traveler stayed at Tru By Hilton Santee
Posted 4 days ago
Tru By Hilton Santee

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