St. James Vacation Homes

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Featured Vacation Homes in St. James

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in St. James

    Greenlight Inn & Suites

    Greenlight Inn & Suites

    110 N Outer Rd St. James MO
    $68 nightly
    The price is $77 total per night from Aug 26 to Aug 27
    $77 total
    Aug 26 - Aug 27
    Total with taxes and fees
    8.6/10 Excellent! (584 reviews)
    Economy Inn

    Economy Inn

    102 N Outer Rd St. James MO
    $50 nightly
    The price is $57 total per night from Aug 26 to Aug 27
    $57 total
    Aug 26 - Aug 27
    Total with taxes and fees
    Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.

    Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.

    Saint James MO
    $132 nightly
    The price is $142 total per night from Aug 26 to Aug 27
    $142 total
    Aug 26 - Aug 27
    Total with taxes and fees
    10/10 Exceptional! (77 reviews)

St. James Vacation Homes

Book vacation homes in St. James
Next time you take a group getaway top St. James, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of St. James vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every St. James vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in St. James; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a St. James rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to St. James is sure to be a winner.

St. James Vacation Homes essential information

Accommodation
77 Vacation Homes
Lowest Price
$57
Highest Price
$327
Popular accommodation
The Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James , The James Stay on Historic Route 66 • minutes away from Wineries & Restaurants, Spacious 3BR Retreat | Sleeps 6 | Near Downtown, Peaceful relaxing and fun , Vineyard Ridge Farmhouse • 3BR • 2BA • Vineyard View • Fire pit • , Charming house near Maramec Spring Park, Steelville/St. James, 4 bedrooms Sleeps 14, Cozy Home on the edge of Rolla!, Club Boulders by Pinemark® Pool+Pickleball+HotTub

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