St. James Vacation Homes

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Featured Vacation Homes in St. James

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in St. James

    Greenlight Inn & Suites

    Greenlight Inn & Suites

    110 N Outer Rd St. James MO
    $68 nightly
    The price is $77 total per night from Jun 1 to Jun 2
    $77 total
    Jun 1 - Jun 2
    Total with taxes and fees
    8.6/10 Excellent! (497 reviews)
    Economy Inn

    Economy Inn

    102 N Outer Rd St. James MO
    $50 nightly
    The price is $57 total per night from May 26 to May 27
    $57 total
    May 26 - May 27
    Total with taxes and fees
    8.2/10 Very Good! (490 reviews)
    Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.

    Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.

    Saint James MO
    $157 nightly
    The price is $169 total per night from May 28 to May 29
    $169 total
    May 28 - May 29
    Total with taxes and fees
    10/10 Exceptional! (62 reviews)

St. James Vacation Homes

Book vacation homes in St. James
Next time you take a group getaway top St. James, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of St. James vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every St. James vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in St. James; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a St. James rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to St. James is sure to be a winner.

St. James Vacation Homes essential information

Accommodation
72 Vacation Homes
Lowest Price
$57
Highest Price
$645
Popular accommodation
Spacious 4-Bedroom Modern Farmhouse Ideal Family Getaway & Gatherings, Scenic Lakeside Chateau with Heated Pool, Hot Tub & Outdoor Kitchen-TV-Fireplace, Peaceful relaxing and fun , Leasburg Lakehouse vacation home & private stocked lake near Meramec River., The James Stay on Historic Route 66 • minutes away from Wineries & Restaurants, Farm View/Pool/FirePit/PS4/85"TV, Simply Sweet 3 Bedroom Home - near MS&T & Fort Leonard Wood, Secluded farmhouse retreat - Meramec river access!, 4 bedrooms Sleeps 14

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