Southeast Missouri Vacation Homes

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Featured Vacation Homes in Southeast Missouri

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Southeast Missouri

    Baymont Inn and Suites by Wyndham Farmington, MO

    Baymont Inn and Suites by Wyndham Farmington, MO

    1625 W Columbia St, Farmington, MO
    $54 nightly
    The price is $61 total per night from Oct 26 to Oct 27
    $61 total
    Oct 26 - Oct 27
    Total with taxes and fees
    8/10 Very Good! (1,003 reviews)
    Drury Plaza Hotel Cape Girardeau Conference Center

    Drury Plaza Hotel Cape Girardeau Conference Center

    3351 Percy Drive, Cape Girardeau, MO
    $90 nightly
    The price is $102 total per night from Oct 12 to Oct 13
    $102 total
    Oct 12 - Oct 13
    Total with taxes and fees
    9.4/10 Exceptional! (1,008 reviews)
    The Riverview

    The Riverview

    777 Main St, Cape Girardeau, MO
    $132 nightly
    The price is $149 total per night from Nov 2 to Nov 3
    $149 total
    Nov 2 - Nov 3
    Total with taxes and fees
    9.2/10 Wonderful! (428 reviews)

Southeast Missouri Vacation Homes

Book vacation homes in Southeast Missouri
Next time you take a group getaway top Southeast Missouri, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Southeast Missouri vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Southeast Missouri vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Southeast Missouri; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Southeast Missouri rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Southeast Missouri is sure to be a winner.

Southeast Missouri Vacation Homes essential information

Accommodation
175 Vacation Homes
Lowest Price
$61
Highest Price
$245
Popular accommodation
The Sutton House 2 blocks from Main Street & Courthouse Square, Doves Nest Guest House
Tranquil & Relaxing , Your home away from home in downtown, historic Farmington!, Clifford's Country Cottage, Unique cabins in the woods
Not friendly for Street Bikes. , Beautiful 3-bedrm , 3.5 ba Log/Stone in Eminence MO. Will sleep up to 16 guests., Little Blue Cottage on Spanish, Serenity South -- Gardens, River-Views, and Refreshing Space, “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

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