Southeast Missouri Vacation Homes

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Featured Vacation Homes in Southeast Missouri

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Southeast Missouri

    Baymont Inn and Suites by Wyndham Farmington, MO

    Baymont Inn and Suites by Wyndham Farmington, MO

    1625 W Columbia St, Farmington, MO
    $56 nightly
    The price is $64 total per night from Jun 3 to Jun 4
    $64 total
    Jun 3 - Jun 4
    Total includes taxes and fees
    8/10 Very Good! (951 reviews)
    Drury Plaza Hotel Cape Girardeau Conference Center

    Drury Plaza Hotel Cape Girardeau Conference Center

    3351 Percy Drive, Cape Girardeau, MO
    $90 nightly
    The price is $102 total per night from Jun 1 to Jun 2
    $102 total
    Jun 1 - Jun 2
    Total includes taxes and fees
    9.4/10 Exceptional! (1,001 reviews)
    The Riverview

    The Riverview

    777 Main St, Cape Girardeau, MO
    $107 nightly
    The price is $121 total per night from Jun 1 to Jun 2
    $121 total
    Jun 1 - Jun 2
    Total includes taxes and fees
    9.2/10 Wonderful! (272 reviews)

Southeast Missouri Vacation Homes

Book vacation homes in Southeast Missouri
Next time you take a group getaway top Southeast Missouri, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Southeast Missouri vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Southeast Missouri vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Southeast Missouri; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Southeast Missouri rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Southeast Missouri is sure to be a winner.

Southeast Missouri Vacation Homes essential information

Accommodation
172 Vacation Homes
Lowest Price
$64
Highest Price
$610
Popular accommodation
"Little Brick House on Main (1865)”, Unbeatable convenience in amazing Eminence!, Quaint, Beautiful Home next to SEMO and Hospital, 5-Bedroom house on Current River, Living Waters Estates, Elegant 3 BR Home with kids area, hot tub, sleeps 12, Clifford's Country Cottage, RIVER FRONT HOUSE, Your home away from home in downtown, historic Farmington!, Secluded Gate House