Southeast Missouri Vacation Homes

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Featured Vacation Homes in Southeast Missouri

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Southeast Missouri

    Drury Plaza Hotel Cape Girardeau Conference Center

    Drury Plaza Hotel Cape Girardeau Conference Center

    3351 Percy Drive Cape Girardeau MO
    $96 nightly
    The price is $108 total per night from Apr 12 to Apr 13
    $108 total
    Apr 12 - Apr 13
    Total with taxes and fees
    9.6/10 Exceptional! (1,008 reviews)
    The Riverview

    The Riverview

    777 Main St Cape Girardeau MO
    $122 nightly
    The price is $138 total per night from Apr 29 to Apr 30
    $138 total
    Apr 29 - Apr 30
    Total with taxes and fees
    9.4/10 Exceptional! (541 reviews)
    Drury Inn & Suites Sikeston, MO

    Drury Inn & Suites Sikeston, MO

    2608 East Malone Ave, Miner Sikeston MO
    $110 nightly
    The price is $126 total per night from Apr 9 to Apr 10
    $126 total
    Apr 9 - Apr 10
    Total with taxes and fees
    9.4/10 Exceptional! (1,008 reviews)

Southeast Missouri Vacation Homes

Book vacation homes in Southeast Missouri
Next time you take a group getaway top Southeast Missouri, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Southeast Missouri vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Southeast Missouri vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Southeast Missouri; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Southeast Missouri rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Southeast Missouri is sure to be a winner.

Southeast Missouri Vacation Homes essential information

Accommodation
191 Vacation Homes
Lowest Price
$108
Highest Price
$587
Popular accommodation
"Little Brick House on Main (1865)”, Little Blue Cottage on Spanish, “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau, The Sutton House 2 blocks from Main Street & Courthouse Square, Unique cabins in the woods
Not friendly for Street Bikes. , Living Waters Estates, Elegant 3 BR Home with kids area, hot tub, sleeps 12, Unbeatable convenience in amazing Eminence!, Serenity South -- Gardens, River-Views, and Refreshing Space, Shawnee Creek Hideaway - Close to Eminence and the Jacks Fork River!

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