Southeast Missouri Luxury Hotels
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Featured Southeast Missouri Luxury Hotels

Super 8 by Wyndham Pevely
1711 Highway Z Pevely MO
Free Cancellation
Reserve now, pay when you stay
$79 nightly
The price is $91 total per night
$91 total
Mar 31 - Apr 1
Total with taxes and fees
At Super 8 by Wyndham Pevely, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$73 nightly
The price is $77 total per night
$77 total
Mar 31 - Apr 1
Total with taxes and fees
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$68 nightly
The price is $78 total per night
$78 total
Apr 2 - Apr 3
Total with taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a vending machine.
Breakfast included
Pet friendly

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Cape Girardeau MO
At this apartment, guests have access to features like laundry facilities. This smoke-free apartment building also has barbecue grills.
Kitchen
Washer

Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
Free Cancellation
$73 nightly
The price is $83 total per night
$83 total
Apr 19 - Apr 20
Total with taxes and fees
At Comfort Inn Festus - St Louis South, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. Front-desk staff can answer questions 24/7, and assist with tours or tickets, dry cleaning/laundry, and securing valuables. Additional amenities include free newspapers, laundry facilities, and a gift shop.
Breakfast included
Parking included

Super 8 by Wyndham Poplar Bluff Missouri
2831 N Westwood Blvd Poplar Bluff MO
Free Cancellation
Reserve now, pay when you stay
$55 nightly
The price is $62 total per night
$62 total
Apr 12 - Apr 13
Total with taxes and fees
Guests of Super 8 by Wyndham Poplar Bluff Missouri enjoy free WiFi in public areas, a 24-hour business center, and laundry facilities. There's free parking if you drive. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Additional amenities include a picnic area, a vending machine, and an ATM.
Breakfast included
Pet friendly

Baymont by Wyndham Festus
1200 W. Gannon Drive Festus MO
Free Cancellation
Reserve now, pay when you stay
$69 nightly
The price is $79 total per night
$79 total
Apr 12 - Apr 13
Total with taxes and fees
At Baymont by Wyndham Festus, guests enjoy an indoor pool, a gym, and free WiFi in public areas. There's free parking and a free beach shuttle. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Quality Inn Cape Girardeau North
2011 North Kingshighway Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$67 nightly
The price is $75 total per night
$75 total
Apr 6 - Apr 7
Total with taxes and fees
Guests of Quality Inn Cape Girardeau North enjoy features like an outdoor pool, free WiFi in public areas, and a computer station. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready. Additional amenities include laundry facilities, a TV in a common area, and a vending machine.
Pool
Breakfast included

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $108 total per night
$108 total
Apr 5 - Apr 6
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Free Cancellation
Reserve now, pay when you stay
$94 nightly
The price is $106 total per night
$106 total
Apr 7 - Apr 8
Total with taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with luggage storage and securing valuables. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 630 hotels |
|---|---|
Lowest Price | $62 |
Highest Price | $108 |
Popular hotels | Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Baymont by Wyndham Festus, Quality Inn Cape Girardeau North, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau |
Recent Luxury Hotels Reviews

Hampton Inn Sikeston
5/5 Excellent
"Yes"
A verified traveler stayed at Hampton Inn Sikeston
Posted 2 hours ago
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