Southeast Missouri Luxury Hotels
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Featured Southeast Missouri Luxury Hotels

Super 8 by Wyndham Pevely
1711 Highway Z, Pevely, MO
At Super 8 by Wyndham Pevely, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
$76 nightly
The price is $80 total per night
$80 total
Nov 16 - Nov 17
Total with taxes and fees
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$63 nightly
The price is $72 total per night
$72 total
Nov 16 - Nov 17
Total with taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a banquet hall.
Breakfast included
Pet friendly

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Guests of this apartment enjoy access to a water park, laundry facilities, and barbecue grills.
Kitchen
Washer

Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Nov 17 - Nov 18
Total with taxes and fees
Guests of Pear Tree Inn Cape Girardeau Near the Medical Center enjoy free WiFi in public areas, coffee in a common area, and express check-out. Front-desk staff are standing by 24/7 to assist with any requests. This smoke-free hotel also has a TV in a common area.
Pet friendly
Free WiFi

Comfort Inn Festus - St Louis South
1303 Veterans Blvd, Festus, MO
Free Cancellation
Reserve now, pay when you stay
$82 nightly
The price is $93 total per night
$93 total
Nov 16 - Nov 17
Total with taxes and fees
At Comfort Inn Festus - St Louis South, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. Front-desk staff can answer questions 24/7, and assist with securing valuables, dry cleaning/laundry, and tours or tickets. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Breakfast included
Parking included

Super 8 by Wyndham Poplar Bluff Missouri
2831 N Westwood Blvd, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
$54 nightly
The price is $61 total per night
$61 total
Dec 7 - Dec 8
Total with taxes and fees
Guests of Super 8 by Wyndham Poplar Bluff Missouri enjoy free WiFi in public areas, a 24-hour business center, and laundry facilities. There's free parking if you drive. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Additional amenities include an ATM, a picnic area, and a vending machine.
Breakfast included
Pet friendly

Baymont by Wyndham Festus
1200 W. Gannon Drive, Festus, MO
Free Cancellation
Reserve now, pay when you stay
$81 nightly
The price is $93 total per night
$93 total
Nov 16 - Nov 17
Total with taxes and fees
At Baymont by Wyndham Festus, guests enjoy an indoor pool, a gym, and free WiFi in public areas. There's free parking and a free beach shuttle. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$58 nightly
The price is $65 total per night
$65 total
Nov 19 - Nov 20
Total with taxes and fees
Guests of Quality Inn enjoy features like an outdoor pool, free WiFi in public areas, and a computer station. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready. Additional amenities include laundry facilities, a vending machine, and a TV in a common area.
Pool
Breakfast included

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$96 nightly
The price is $110 total per night
$110 total
Nov 17 - Nov 18
Total with taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Nov 23 - Nov 24
Total with taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a hot tub, meeting rooms, and a business center.
Pool
Hot Tub
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 600 hotels |
|---|---|
Lowest Price | $61 |
Highest Price | $110 |
Popular hotels | Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Baymont by Wyndham Festus, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau |
Recent Luxury Hotels Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
5/5 Excellent
"Thanks "
A verified traveler stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Posted 4 days ago
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