Southeast Missouri Luxury Hotels
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Featured Southeast Missouri Luxury Hotels

Super 8 by Wyndham Pevely
1711 Highway Z, Pevely, MO
At Super 8 by Wyndham Pevely, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.

Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
$79 nightly
The price is $83 total per night
$83 total
Jul 28 - Jul 29
Total includes taxes and fees
Guests staying at Motel 6 Poplar Bluff, MO enjoy free WiFi in public areas, laundry facilities, and a vending machine. You can take advantage of free parking if you drive. The front desk is staffed 24 hours a day to help with tours/tickets and luggage storage.
Pet friendly
Parking included

Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$71 nightly
The price is $81 total per night
$81 total
Aug 3 - Aug 4
Total includes taxes and fees
Renovated in 2023, Days Inn and Suites by Wyndham Sikeston offers a gym, free WiFi in public areas, and meeting rooms. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a library, laundry facilities, and a banquet hall.

Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Guests of this apartment enjoy access to a water park, laundry facilities, and barbecue grills.
Kitchen
Washer

Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$70 nightly
The price is $79 total per night
$79 total
Jul 28 - Jul 29
Total includes taxes and fees
Guests of Pear Tree Inn Cape Girardeau Near the Medical Center enjoy free WiFi in public areas, coffee in a common area, and express check-out. Front-desk staff are standing by 24/7 to assist with any requests. This smoke-free hotel also has a TV in a common area.
Pet friendly
Free WiFi

Comfort Inn Festus - St Louis South
1303 Veterans Blvd, Festus, MO
Free Cancellation
Reserve now, pay when you stay
$84 nightly
The price is $95 total per night
$95 total
Aug 24 - Aug 25
Total includes taxes and fees
At Comfort Inn Festus - St Louis South, guests have access to a gym, free WiFi in public areas, and a business center. Free parking is included with your stay. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, securing valuables, and tours or tickets. Additional amenities include free newspapers, laundry facilities, and a vending machine.

Super 8 by Wyndham Poplar Bluff Missouri
2831 N Westwood Blvd, Poplar Bluff, MO
Free Cancellation
Reserve now, pay when you stay
$59 nightly
The price is $66 total per night
$66 total
Aug 7 - Aug 8
Total includes taxes and fees
Guests of Super 8 by Wyndham Poplar Bluff Missouri enjoy free WiFi in public areas, a 24-hour business center, and laundry facilities. There's free parking if you drive. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Additional amenities include a vending machine, an ATM, and a picnic area.
Breakfast included
Pet friendly

Quality Inn Festus
1200 W Gannon Dr, Festus, MO
At Quality Inn Festus, guests enjoy an indoor pool, a gym, and free WiFi in public areas. There's free parking and a free beach shuttle. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and coffee/tea in a common area.

Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$67 nightly
The price is $76 total per night
$76 total
Jul 28 - Jul 29
Total includes taxes and fees
Guests of Quality Inn enjoy features like an outdoor pool, free WiFi in public areas, and a computer station. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready. Additional amenities include laundry facilities, a TV in a common area, and a vending machine.
Pool
Breakfast included

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $103 total per night
$103 total
Aug 14 - Aug 15
Total includes taxes and fees
Drury Inn & Suites Sikeston, MO features an indoor pool, an outdoor pool, and a gym. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and a business center.
Pool
Breakfast included

Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Free Cancellation
Reserve now, pay when you stay
$90 nightly
The price is $102 total per night
$102 total
Aug 1 - Aug 2
Total includes taxes and fees
Guests of Drury Inn & Suites Cape Girardeau have access to an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a hot tub, meeting rooms, and a business center.
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southeast Missouri hotels essential information
Accommodation | 588 hotels |
---|---|
Lowest Price | $66 |
Highest Price | $103 |
Popular hotels | Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Quality Inn Festus, Quality Inn, Drury Inn & Suites Sikeston, MO, Drury Inn & Suites Cape Girardeau |
Recent Luxury Hotels Reviews

The Farmstead Hotel
5/5 Excellent
"Highly recommend to anyone staying for a night or having a casino getaway in a quiet town. Girl who helped me check in wednesday afternoon was very helpful ."
A verified traveler stayed at The Farmstead Hotel
Posted 3 days ago
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