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Comfort Inn & Suites Sikeston I-55

2.5 star property
Hotel in Sikeston with a fitness center and a 24-hour front desk

Choose dates to view prices

Photo gallery for Comfort Inn & Suites Sikeston I-55

Exterior
Lobby
Room, 2 Queen Beds, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks
Meeting facility
Breakfast area

Reviews

8.4 out of 10
Very good

Popular amenities

  • Gym
  • Laundry
  • Pet friendly
  • Parking included
  • Free WiFi

Explore the area

View in a map
109 Matthews Ln, Sikeston, MO, 63801
  • Place, City of Miner Convention Center
    ‪5 min walk‬
  • Place, Isle Casino Cape Girardeau
    ‪33 min drive‬
  • Place, Southeast Missouri State University
    ‪33 min drive‬
  • Airport, Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    ‪24 min drive‬

Room options

View all photos for Standard Room, 2 Queen Beds, Non Smoking

Standard Room, 2 Queen Beds, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 2 Queen Beds, Non Smoking

8.0 out of 10
Very good
(11 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Suite, 1 King Bed with Sofa bed, Non Smoking

Suite, 1 King Bed with Sofa bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Suite, 1 King Bed with Sofa bed, Non Smoking

  • 1 bedroom
  • Sleeps 4
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Room, 1 King Bed, Accessible, Non Smoking

Room, 1 King Bed, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 1 King Bed, Accessible, Non Smoking

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds, Accessible, Non Smoking

Room, 2 Queen Beds, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Room, 2 Queen Beds, Accessible, Non Smoking

10.0 out of 10
Exceptional
(4 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Standard Room, 1 King Bed, Non Smoking

Standard Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks

Standard Room, 1 King Bed, Non Smoking

8.0 out of 10
Very good
(14 reviews)
  • Sleeps 2
  • 1 King Bed

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    About the neighborhood

    Sikeston

    Located within a leisurely stroll of City of Miner Convention Center, Comfort Inn & Suites Sikeston I-55 is within a 10-minute drive of Sikeston Depot Museum. This 64-room hotel welcomes guests with conveniences like an indoor pool, free in-room WiFi, and free self parking.

    What's nearby

    • City of Miner Convention Center - 5 min walk - 0.3 miles
    • Saint Francis Medical Center - 28 min drive - 36.0 miles
    • Isle Casino Cape Girardeau - 33 min drive - 38.0 miles
    • Southeast Missouri State University - 33 min drive - 38.5 miles
    • Show Me Center - 34 min drive - 39.1 miles

    Getting around

    • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 29 min drive

    Restaurants

    • ‪Lambert's Cafe - ‬17 min walk
    • ‪Buffalo Wild Wings - ‬5 min drive
    • ‪Pizza Inn - ‬2 min drive
    • ‪Burger King - ‬4 min drive
    • ‪McDonald's - ‬2 min walk

    About this property

    Comfort Inn & Suites Sikeston I-55

    Hotel in Sikeston with a fitness center and a 24-hour front desk
    At Comfort Inn & Suites Sikeston I-55, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. A stay here includes free parking. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Additional amenities include a business center and laundry facilities.
    Guests can expect to find free WiFi. Other amenities include coffee makers, phones, and desks.
    Recreational amenities at the hotel include an indoor pool and a fitness center.

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    Drury Inn & Suites Sikeston, MO
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    • Breakfast included
    • Pet friendly
    • Parking included
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    Dec 2 - Dec 3
    Total with taxes and fees
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    Property amenities

    Internet

    • Available in all rooms: Free WiFi
    • Available in some public areas: Free WiFi

    Parking and transportation

    • Free self parking on site
    • Wheelchair-accessible parking available

    Things to do

    • Gym
    • Indoor pool

    Family friendly

    • Indoor pool
    • Laundry facilities

    Conveniences

    • 24-hour front desk
    • Laundry facilities
    • Safe at front desk

    Business services

    • Business center

    Accessibility

    • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
    • Elevator
    • Wheelchair accessible (may have limitations)
    • Wheelchair-accessible parking
    • Wheelchair-accessible registration desk

    More

    • 3 floors
    • Smoking not allowed

    Room amenities

    Bedroom

    • Bedsheets provided

    Bathroom

    • Bathtub or shower
    • Private bathroom
    • Towels provided

    Entertainment

    • Cable/satellite channels

    Food and drink

    • Coffee/tea maker

    More

    • Air conditioning
    • Desk
    • Phone

    Policies

    Check-in

    Check-in start time: 2:00 PM; Check-in end time: anytime
    Minimum check-in age: 21

    Check-out

    Check-out before 11:00 AM

    Special check-in instructions

    Front desk staff will greet guests on arrival at the property
    Information provided by the property may be translated using automated translation tools

    Access methods

    Staffed front desk

    Pets

    • This property welcomes pets for USD 20 per pet, per night
    • Dogs and cats only
    • 2 total (20 lbs is the maximum weight per pet)
    • Certain rooms only
    • Guests can request a pet-friendly room by contacting the property at the number on the booking confirmation
    • Service animals exempt from fees

    Property payment types

    Important information

    Optional extras

    These fees and deposits will be charged at check-in, check-out, or the time of service.

    • Pet fee: USD 20 per pet, per night
    • Service animals are exempt from fees

    This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

    You need to know

    Extra-person charges may apply and vary depending on property policy
    Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
    Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
    This property accepts credit cards; cash is not accepted
    This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)
    • Check-in: 2:00 PM
    • Check-out: 11:00 AM
    • Minimum check-in age: 21
    The front desk is open 24 hours a day. Driving? This property offers free parking.

    We should mention

    Details about charges, deposits, or other important information:

    • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
    • Charges for extra guests may apply and vary depending on the property's policy.
    • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
    • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
    • This property accepts credit cards. Cash is not accepted. 
    • This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice).

    Additional information about polices, regulations, and more:

    • No cribs or infant beds are available.
    • No rollaway or extra beds are available.

    Property is also known as

    Comfort Inn Sikeston Hotel
    Comfort Inn Sikeston

    Frequently asked questions

    Is free cancellation available at Comfort Inn & Suites Sikeston I-55?

    Comfort Inn & Suites Sikeston I-55 provides free cancellation on some room rates. For additional details, look at the cancellation policy on our site.

    How much does it cost to stay at Comfort Inn & Suites Sikeston I-55?

    As of Nov 28, 2025, prices found for a 1-night stay for 2 adults at Comfort Inn & Suites Sikeston I-55 on Dec 7, 2025 start from $84.15, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

    What's there to do close to Comfort Inn & Suites Sikeston I-55?

    This hotel is located in Sikeston, close to Central Park and Sikeston Depot Museum.

    Will I be able to park at Comfort Inn & Suites Sikeston I-55?

    Yes, self parking is offered for free at the hotel. Accessible parking is also available for guests.

    Does Comfort Inn & Suites Sikeston I-55 have a casino?

    No, Comfort Inn & Suites Sikeston I-55 doesn't have a casino.

    Is there an indoor pool at Comfort Inn & Suites Sikeston I-55?

    Yes, this hotel has an indoor pool.

    What amenities will couples enjoy at Comfort Inn & Suites Sikeston I-55?

    Amenities at this hotel that appeal to couples include an indoor pool and a 24-hour front desk.

    Does Comfort Inn & Suites Sikeston I-55 have a hot tub?

    No, this hotel doesn't have a spa tub.

    Does Comfort Inn & Suites Sikeston I-55 have a restaurant that serves breakfast?

    No, Comfort Inn & Suites Sikeston I-55 doesn't have a restaurant that serves breakfast.

    Does Comfort Inn & Suites Sikeston I-55 allow pets to stay for free?

    Although they can't stay for free, cats and dogs are welcome at Comfort Inn & Suites Sikeston I-55 for a fee of USD 20 per pet, per night.

    Are there connecting rooms at Comfort Inn & Suites Sikeston I-55?

    No, there aren't connecting guestrooms at this hotel.

    How far is the airport from Comfort Inn & Suites Sikeston I-55?

    The closest major airport to Comfort Inn & Suites Sikeston I-55 is Cairo, IL (CIR-Cairo Regional), which is 28.1 mi away (29 minutes by car). Another top airport is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is located 26.7 mi away (29-minute drive).

    Are there rooms with balconies at Comfort Inn & Suites Sikeston I-55?

    No, there aren't any guestrooms with balconies at Comfort Inn & Suites Sikeston I-55.

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