Hotels in Seneca

Search over 1,508 hotels from $59

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

May 15 - May 16
Tonight
Check prices in Seneca for tonight, May 15 - May 16
May 16 - May 17
Tomorrow night
Check prices in Seneca for tomorrow night, May 16 - May 17

Top Rated Seneca Hotels

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
5.27 mi from city center
The price is $109 per night
$109
per night
May 16 - May 17
Guests staying at Lakeside Lodge Clemson enjoy a 24-hour gym, free WiFi in public areas, and a spa tub. Free parking is available if you drive. The front desk is staffed 24 hours a day to help with concierge services and securing valuables. This hotel also has a seasonal outdoor pool.
Hot Tub
Pet friendly
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
5.12 mi from city center
The price is $106 per night
$106
per night
May 31 - Jun 1
Tru by Hilton Seneca Clemson features a gym, free WiFi in public areas, and a business center. You can take advantage of free parking if you drive. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include coffee/tea in a common area, an arcade/game room, and laundry facilities.
Pet friendly
Breakfast included
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
1.92 mi from city center
The price is $71 per night
$71
per night
May 30 - May 31
Guests of Days Inn by Wyndham Seneca / Clemson Area enjoy access to free WiFi in public areas, conference space, and a business center. A stay here includes free parking. The 24-hour front desk has staff always at the ready. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and free newspapers.
Pet friendly
Breakfast included
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
1.15 mi from city center
The price is $110 per night
$110
per night
Jun 9 - Jun 10
Hampton Inn & Suites Seneca-Clemson Area features a 24-hour gym, free WiFi in public areas, and a 24-hour business center. There's free parking if you drive. Front-desk staff can answer questions 24/7, and assist with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a meeting room.
Breakfast included
Pool
Quality Inn Seneca US-123

Quality Inn Seneca US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Free Cancellation
Reserve now, pay when you stay
0.16 mi from city center
The price is $89 per night
$89
per night
Jun 6 - Jun 7
Guests of Quality Inn Seneca US-123 enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include coffee/tea in a common area, a vending machine, and a water dispenser.
Pet friendly
Breakfast included
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

4.53 mi from city center
The price is $795 per night
$795
per night
May 23 - May 24
At this vacation home, guests have access to a spa tub, an arcade/game room, and local meal delivery service. Other amenities at this family-friendly vacation home include a garden and barbecue grills.
Hot Tub
Fireplace
June Discounted Rates! Waterfront Home w/ Covered Dock, 2 Decks, & Pet Friendly

June Discounted Rates! Waterfront Home w/ Covered Dock, 2 Decks, & Pet Friendly

5.82 mi from city center
Guests staying at this vacation home have access to an arcade/game room, a garden, and barbecue grills.
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
6.55 mi from city center
The price is $169 per night
$169
per night
May 19 - May 20
The Shepherd Hotel Downtown Clemson features free WiFi in public areas and a TV in a common area. Valet parking is available for USD 22 per night. Front-desk staff can answer questions 24/7, and assist with securing valuables, concierge services, and luggage storage. Additional amenities include a water dispenser, a reception hall, and a porter/bellhop.
Pet friendly
Breakfast available
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd, Anderson, SC
Free Cancellation
Reserve now, pay when you stay
16.01 mi from city center
The price is $59 per night
$59
per night
Jun 3 - Jun 4
Guests of Days Inn by Wyndham Anderson enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is included with your stay. The front desk is staffed 24 hours a day to help with access to locker space and securing valuables. Additional amenities include coffee/tea in a common area, free use of bicycles, and a computer station.
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
7.18 mi from city center
The price is $87 per night
$87
per night
May 18 - May 19
Guests of Inn @ Clemson enjoy a gym, free WiFi in public areas, and meeting rooms. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help with concierge services, and answer any questions about the accommodations. Additional amenities include a business center, coffee/tea in a common area, and a microwave in a common area.
Breakfast included
Parking included
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
Free Cancellation
Reserve now, pay when you stay
7.27 mi from city center
The price is $101 per night
$101
per night
Jun 11 - Jun 12
Best Western Plus Clemson Hotel & Conference Center features a 24-hour gym, free WiFi in public areas, and meeting rooms. You can put free parking to good use if you drive. Multilingual staff at the 24-hour front desk can assist with luggage storage, concierge services, and securing valuables. Additional amenities include a conference center, a 24-hour business center, and a seasonal outdoor pool.
Pet friendly
Breakfast included
Holiday Inn Express & Suites Clemson, an IHG Hotel

Holiday Inn Express & Suites Clemson, an IHG Hotel

2.5 out of 5
1381 Tiger Blvd, Clemson, SC
Free Cancellation
7.67 mi from city center
The price is $119 per night
$119
per night
May 19 - May 20
At Holiday Inn Express & Suites Clemson, an IHG Hotel, guests have access to a gym, free WiFi in public areas, and a conference center. A stay here includes free parking. Multilingual staff at the front desk are standing by 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a business center, a computer station, and express check-out.
Don't see what you're looking for?
See all available properties in Seneca
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cheap Seneca hotels options

    Days Inn by Wyndham Seneca / Clemson Area

    Days Inn by Wyndham Seneca / Clemson Area

    11015 N Radio Station Rd, Seneca, SC
    The price is $71 per night from May 30 to May 31
    $71
    per night
    May 30 - May 31
    6.8/10 (599 reviews)
    Best Western Seneca-Clemson

    Best Western Seneca-Clemson

    511 Bypass Highway 123, Seneca, SC
    The price is $99 per night from Jun 11 to Jun 12
    $99
    per night
    Jun 11 - Jun 12
    8.4/10 Very Good! (518 reviews)
    Quality Inn Seneca US-123

    Quality Inn Seneca US-123

    226 Hi Tech Rd, Seneca, SC
    The price is $89 per night from Jun 6 to Jun 7
    $89
    per night
    Jun 6 - Jun 7
    7.8/10 Good! (480 reviews)

What's the best place for a stay in Seneca?

What are the best hotels for a stay with my pet in Seneca?

You and your furry companion will find 7 pet-friendly hotels in Seneca for your trip. Lakeside Lodge Clemson is a pet-friendly hotel with free WiFi, free parking, and a 24-hour fitness center. You and your pet can also consider Tru by Hilton Seneca Clemson, a pet-friendly hotel with free breakfast, free WiFi, and free parking. Quality Inn Seneca US-123 is another option, and it's a pet-friendly hotel with free breakfast, free WiFi, and free parking.

What are the best hotels in central Seneca?

Here are some of our travelers' favorite hotels in the center of Seneca:

Stop in at the coffeehouses in family-friendly Seneca, and then enjoy the local attractions such as the sporting events.

What are some favorite hotels near Keowee Reservoir?

Get out into nature at this local spot, located 3.8 mi from the heart of Seneca. There are 68 hotels within 5 miles of Keowee Reservoir, giving you plenty of options to choose from including:

Seneca hotels essential information

Accommodation
1,508 hotels
Lowest Price
$59
Highest Price
$795
Popular hotels
Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson, Days Inn by Wyndham Seneca / Clemson Area, Hampton Inn & Suites Seneca-Clemson Area, Quality Inn Seneca US-123, 5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!, June Discounted Rates! Waterfront Home w/ Covered Dock, 2 Decks, & Pet Friendly, The Shepherd Hotel Downtown Clemson, Days Inn by Wyndham Anderson, Inn @ Clemson, Best Western Plus Clemson Hotel & Conference Center, Holiday Inn Express & Suites Clemson, an IHG Hotel

Recent Reviews

Lakeside Lodge Clemson

Lakeside Lodge Clemson

5/5 Excellent
"Nice rooms located along the lake with shops and restaurants walkable next door. Comfortable bed and clean room. Definitely would stay again. "
A verified traveler from San Jose stayed at Lakeside Lodge Clemson
Posted 4 days ago
Lakeside Lodge Clemson

Areas Of Seneca

Hotels Near

Hotel Themes

Flights To