Business Hotels in Seneca, SC
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Seneca Business Hotels
Best Western Seneca-Clemson
511 Bypass Highway 123 Seneca SC
Free Cancellation
Reserve now, pay when you stay
$84 nightly
The price is $93 total per night
$93 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Guests of Best Western Seneca-Clemson enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. If you plan to drive, free parking is available. The 24-hour front desk has staff always at the ready. Additional amenities include a computer station, free newspapers, and a vending machine.
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street Seneca SC
Free Cancellation
Reserve now, pay when you stay
$119 nightly
The price is $131 total per night
$131 total
Dec 28 - Dec 29
Total with taxes and fees
Hampton Inn & Suites Seneca-Clemson Area features a 24-hour gym, free WiFi in public areas, and a 24-hour business center. There's free parking if you drive. Front-desk staff can answer questions 24/7, and assist with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a seasonal outdoor pool, coffee/tea in a common area, and a meeting room.
Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd Seneca SC
Free Cancellation
Reserve now, pay when you stay
$73 nightly
The price is $80 total per night
$80 total
Dec 28 - Dec 29
Total with taxes and fees
Guests of Days Inn by Wyndham Seneca / Clemson Area enjoy access to free WiFi in public areas, a seasonal outdoor pool, and coffee in a common area. A stay here includes free parking. The 24-hour front desk has staff always at the ready. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Pool
Breakfast included
Quality Inn Seneca Clemson Area US-123
226 Hi Tech Rd Seneca SC
Free Cancellation
Reserve now, pay when you stay
$79 nightly
The price is $87 total per night
$87 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests of Quality Inn Seneca Clemson Area US-123 enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. Free parking is available if you drive. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include coffee/tea in a common area, a water dispenser, and a vending machine.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Seneca hotels essential information
Accommodation | 1,655 hotels |
|---|---|
Lowest Price | $80 |
Highest Price | $131 |
Popular hotels | Best Western Seneca-Clemson, Hampton Inn & Suites Seneca-Clemson Area, Days Inn by Wyndham Seneca / Clemson Area, Quality Inn Seneca Clemson Area US-123 |
Recent Business Hotels Reviews
Tru by Hilton Seneca Clemson
5/5 Excellent
"Staff is amazing, hotel and amenities are great. "
A verified traveler stayed at Tru by Hilton Seneca Clemson
Posted 2 days ago
