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Featured Vacation Homes in Panama

Bocas Villas - Private Acqua Villas
Bocas Villas - Private Acqua Villas
Bocas del Toro, Bocas del Toro (province)
Guests of this vacation home have access to designated smoking areas.
Hacienda mi Montañita
Hacienda mi Montañita
3.0 out of 5.0 Calle Los Altos de Cerro Azul, El Portin, Cerro Azul, Panama
$77
Guests of Hacienda mi Montañita enjoy features like an outdoor pool, free WiFi in public areas, and a terrace. Free parking is available if you drive. This smoke-free ...
Casa Little Italy
Casa Little Italy
3.0 out of 5.0 Urbanizacion Dona Fela 40, Boqueron, Chiriqui
Guests of this vacation home enjoy features like an outdoor pool, free WiFi in public areas, and a terrace. You can take advantage of free parking, along with ...
Marina beach house
Marina beach house
3.0 out of 5.0 Carr. Nombre de Dios, Nombre de Dios, Colon
Guests of this vacation home enjoy features like an outdoor pool, WiFi in public areas, and a terrace. You can put free parking to good use if you drive. Additional ...
Casita La Ermita
Casita La Ermita
2.5 out of 5.0 La Ermita, Sainillo, San Carlos, Panama
Guests staying at Casita La Ermita enjoy an outdoor pool, express check-in, and express check-out. There's free parking if you drive. Multilingual staff is on ...
Complete House in Gamboa, by Panama Canal-casa Completa en Gamboa
Complete House in Gamboa, by Panama Canal-casa Completa en Gamboa
Gamboa, Colon
At this vacation home, guests have access to a garden.
A House for Rent in Anton Valley - A Piece of Paradise
A House for Rent in Anton Valley - A Piece of Paradise
El Valle de Anton, cocle
$90
At this vacation home, guests have access to a garden.
Sand Dollar Villa
Sand Dollar Villa
3.5 out of 5.0 Lobster Cove Boca Chica Playa Hermosa, Boca Chica
$275
This vacation home features an indoor pool, free WiFi in public areas, and microwave in a common area. If you decide to drive, there's free parking. Front-desk ...
Country House in La Laguna de San Carlos Panama
Country House in La Laguna de San Carlos Panama
panama, panama
$70
This vacation home is a smoke-free vacation home.
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Panama Vacation Homes

Book vacation homes in Panama
Next time you take a group getaway top Panama, don’t confine your friends and family to one or two hotel rooms. Instead, snag a deal on a full-sized house and get the best of both worlds. Vacation home rentals are perfect for families and large groups that want to live like locals on vacation. Whether you are searching for a villa that pulls out all the stops or a four-bedroom house to host the best summer vacation ever, Orbitz has a variety of Panama vacation homes for rent that are ideal for you. Your perfect pad is only a few clicks away.

Homes for every Panama vacation
If you’re planning a vacation with a lot of people, you’ll want room to stretch out, and a rental home has plenty of space. Many vacation homes also come with everything you’ll need for a proper getaway, like kitchens with every gadget you can think of, along with updated furnishings, fancy spa tubs and balconies. You may even wind up in a rental home that has a sprawling backyard for barbecues, games and general relaxation. These rentals offer the added bonus of putting you right in the thick of things in Panama; instead of going to a small hotel room at the end of a busy day, you’re going home.

Vacations are all about creating lasting memories, and a Panama rental home makes it easy to create good ones. Whether you’re getting the college crowd back together or bringing along your folks and your kids, a trip to Panama is sure to be a winner.

Hotel Options in Panama

See all 1,279 Properties in Panama
*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.