Business Hotels in O'Fallon, MO
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured O'Fallon Business Hotels

Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive O'Fallon MO
Free Cancellation
$79 nightly
The price is $93 total per night
$93 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Guests of Sleep Inn & Suites O'Fallon MO - Technology Drive have access to an indoor pool, a gym, and free WiFi in public areas. Free parking is included with your stay. Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include a 24-hour business center, laundry facilities, and a vending machine.
Pool
Breakfast included

Holiday Inn Express St. Louis West - O'Fallon by IHG
1175 Technology Dr O'Fallon MO
Free Cancellation
$91 nightly
The price is $107 total per night
$107 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Holiday Inn Express St. Louis West - O'Fallon by IHG enjoy an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking, along with a free area shuttle. The front desk is staffed 24/7 to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included

Hilton Garden Inn St. Louis/O'Fallon MO
2310 Technology Dr O'Fallon MO
Free Cancellation
Reserve now, pay when you stay
$95 nightly
The price is $112 total per night
$112 total
Jan 23 - Jan 24, 2026
Total with taxes and fees
At Hilton Garden Inn St. Louis/O'Fallon MO, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Pet friendly

Residence Inn by Marriott O'Fallon
101 Progress Point Ct. O'Fallon MO
Free Cancellation
Reserve now, pay when you stay
$114 nightly
The price is $134 total per night
$134 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
At Residence Inn by Marriott O'Fallon, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, dry cleaning/laundry, and luggage storage. Additional amenities include an outdoor tennis court, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Comfort Inn & Suites St. Louis - O'Fallon
100 Comfort Inn Ct O'Fallon MO
Free Cancellation
Reserve now, pay when you stay
$78 nightly
The price is $92 total per night
$92 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
At Comfort Inn & Suites St. Louis - O'Fallon, guests have access to an indoor pool, free WiFi in public areas, and a business center. A stay here includes free parking. The 24-hour front desk has staff always at the ready. Additional amenities include coffee/tea in a common area, express check-out, and laundry facilities.
Pool
Breakfast included

Staybridge Suites O'Fallon Chesterfield by IHG
1155 Technology Drive O'Fallon MO
Free Cancellation
$116 nightly
The price is $137 total per night
$137 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
Staybridge Suites O'Fallon Chesterfield by IHG features a 24-hour gym, free WiFi in public areas, and meeting rooms. If you drive, put free parking to good use. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include a business center, a seasonal outdoor pool, and free newspapers.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
O'Fallon hotels essential information
Accommodation | 957 hotels |
|---|---|
Lowest Price | $92 |
Highest Price | $137 |
Popular hotels | Sleep Inn & Suites O'Fallon MO - Technology Drive, Holiday Inn Express St. Louis West - O'Fallon by IHG, Hilton Garden Inn St. Louis/O'Fallon MO, Residence Inn by Marriott O'Fallon, Comfort Inn & Suites St. Louis - O'Fallon, Staybridge Suites O'Fallon Chesterfield by IHG |
Recent Business Hotels Reviews

Renaissance St. Louis Airport Hotel
5/5 Excellent
"Clean rooms and friendly, accommodating staff. "
A verified traveler stayed at Renaissance St. Louis Airport Hotel
Posted 4 days ago


