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21c Museum Hotel Louisville

4.5 star property
Luxury hotel with a full-service spa and a 24-hour fitness center

Choose dates to view prices

Photo gallery for 21c Museum Hotel Louisville

Front of property
Interior
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Fountain
Bar (on property)

Reviews

9.2 out of 10
Wonderful

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi
  • Air conditioning
  • Gym

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, 21c Museum Hotel
    ‪1 min walk‬
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, KFC Yum Center
    ‪8 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪10 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(30 reviews)
  • 335 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 435 sq ft
  • City view
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(66 reviews)
  • 350 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.2 out of 10
Wonderful
(33 reviews)
  • 455 sq ft
  • City view
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

  • 660 sq ft
  • City view
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • 315 sq ft
  • City view
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 434 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 435 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

  • City view
  • Sleeps 4
  • 1 Double Bed

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About the neighborhood

Louisville

Located in Downtown Louisville, 21c Museum Hotel Louisville is adjacent to Louisville Slugger Museum and within a 10-minute walk of other popular attractions like KFC Yum Center. This 91-room, 4.5-star hotel has a restaurant, a full-service spa, and a 24-hour gym.

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.0 miles
  • Muhammad Ali Center - 3 min walk - 0.2 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Kentucky International Convention Center - 8 min walk - 0.5 miles
  • KFC Yum Center - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk
  • ‪Proof on Main - ‬1 min walk

About this property

21c Museum Hotel Louisville

Luxury hotel with a full-service spa and a 24-hour fitness center
Guests staying at 21c Museum Hotel Louisville enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 32 per night, and there's also limo/town car service. The front desk has multilingual staff on hand 24/7 to help with securing valuables, luggage storage, and concierge services. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include meeting rooms, conference space, and a 24-hour business center.
50-inch LCD TVs come with cable channels, and guests can stay connected with free WiFi and wired Internet. Beds are dressed in premium bedding and down comforters, and bathrooms offer hair dryers and designer toiletries. IPod docks, minibars, and espresso makers are also standard.
Recreational amenities at the hotel include a 24-hour fitness center.

The recreational activities listed below are available either on site or nearby; fees may apply.

21c Spa has 2 treatment rooms. Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. The spa is equipped with a sauna and a steam room. The spa is open daily.

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Limited onsite valet parking
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance

Business services

  • 24-hour business center
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • Deep-tissue massages
  • Hot stone massages
  • In-room massages
  • Prenatal massages
  • Sauna
  • Spa open daily
  • Sports massages
  • Steam room
  • Swedish massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • At least 80% lighting from LEDs
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • Built in 2006
  • Comprehensive food waste policy
  • Double-glazed windows
  • Eco-friendly cleaning products used
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed
  • Vegan dining options

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 40.00 per accommodation, per stay
  • Pet weight must not exceed 50 lbs per pet
  • Food and water bowls are available
  • Service animals exempt from fees

Children and extra beds

  • Rollaway/extra beds are available for USD 30.0 per night
  • Free cribs/infant beds are available

Property payment types

Important information

Fees

  • Service fee: USD 5.00 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
This property uses eco-friendly cleaning products
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)
  • Check-in: 4 PM
  • Check-out: 11 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply), along with a car charging station.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A credit card for incidental charges and a government-issued photo ID may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • The credit card used at check-in for incidentals must be in the name of the primary guest who made the reservation.
  • This property uses eco-friendly cleaning products.
  • Onsite safety features include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards.
  • This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
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21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
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Louisville 21c Museum Hotel Louisville - MGallery Hotel
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Frequently asked questions

Is a free cancellation option available at 21c Museum Hotel Louisville?

21c Museum Hotel Louisville provides free cancellation on certain room rates. For more details, review the cancellation policy on our site.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Dec 28, 2025, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Jan 1, 2026 start from $139.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What is there to do near 21c Museum Hotel Louisville?

This hotel is situated in Downtown Louisville within a 10-minute walk of Louisville Slugger Museum and KFC Yum Center. You'll also find 21c Museum Hotel and Muhammad Ali Center less than a mile away.

Will I be able to park at 21c Museum Hotel Louisville?

Yes, valet parking is offered for USD 32 per night with in/out privileges. Accessible parking and electric car charging are also available for guests.

Is there a spa at 21c Museum Hotel Louisville?

21c Spa is the hotel's full-service spa and services include deep-tissue massages.

Does 21c Museum Hotel Louisville have a casino at the property?

No, 21c Museum Hotel Louisville doesn't have a casino.

Will I find an indoor pool at 21c Museum Hotel Louisville?

No, there is no indoor pool at this hotel.

What amenities will couples enjoy at 21c Museum Hotel Louisville?

At this boutique hotel, couples will welcome the many amenities including Champagne service and in-room massages along with a bar.

Are there hot tubs at 21c Museum Hotel Louisville?

No, but this hotel does have a steam room.

Does 21c Museum Hotel Louisville have a restaurant that serves breakfast?

Yes, 21c Museum Hotel Louisville serves a full breakfast for a surcharge each morning at Proof on Main.

Will 21c Museum Hotel Louisville allow pets to stay free of charge?

Although they can't stay for free, pets are welcome at 21c Museum Hotel Louisville for a fee of USD 40.00 per accommodation, per stay. The property also provides food and water bowls.

Does 21c Museum Hotel Louisville have connecting rooms?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

How far is the airport from 21c Museum Hotel Louisville?

The closest major airport to 21c Museum Hotel Louisville is Louisville Intl. Airport (SDF), which is 7.1 mi away (10 minutes by car). Another top airport is Louisville, KY (LOU-Bowman Field), which is located 8.1 mi away (11-minute drive).

Can I book a room with a balcony at 21c Museum Hotel Louisville?

Yes, some guestrooms at 21c Museum Hotel Louisville offer a furnished balcony and may feature city views.

21c Museum Hotel Louisville Reviews

Reviews

9.2

Wonderful

Rating 10 - Excellent. 761 out of 1002 reviews
Rating 8 - Good. 137 out of 1002 reviews
Rating 6 - Okay. 61 out of 1002 reviews
Rating 4 - Poor. 23 out of 1002 reviews
Rating 2 - Terrible. 20 out of 1002 reviews

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Jennifer

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing location and great hotel. Staff was great. Restaurant was delicious. Great location on Main Street!!
Stayed 4 nights in Sep 2025

10/10 Excellent

Jennifer

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities
Room was very clean and staff were very friendly.
Stayed 1 night in Sep 2025

10/10 Excellent

jennifer

Loved it!!
Stayed 2 nights in Sep 2025

10/10 Excellent

Jessica

Traveled with partner
Liked: Cleanliness, staff & service, property conditions & facilities
Shout out to the valet staff, super friendly and helpful and truly made the weekend great.
Stayed 3 nights in Sep 2025

10/10 Excellent

Kimberley, Seattle

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fun place to stay! Eclectic, unique and eccentric decor. Really enjoyed the location and convenient, walkable access.
Stayed 3 nights in Sep 2025

10/10 Excellent

Eric

Liked: Cleanliness, staff & service, property conditions & facilities
The art museum is pretty cool. Staff were super nice.
Stayed 5 nights in Sep 2025

10/10 Excellent

Michael Sheridan, Chicago

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very cool art in a perfect location, walkable to so many great venues. Very friendly, helpful staff. The adjacent restaurant, Proof, was cool and delicious. The rooms were well appointed with in room safe, mini fridge, nice shower and comfortable beds. We would definitely stay here again.
Stayed 2 nights in Sep 2025

10/10 Excellent

Heather

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice property. Room was comfortable, easy check in and check out. Staff were pleasant and atmosphere was cool.
Stayed 2 nights in Sep 2025

10/10 Excellent

Cristina

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Worth every mile!

I can’t say enough amazing things about this hotel. It in itself is worth the trip. The exhibits are amazing, the staff were everything you want them to be. They recalled who we were, why we were there…. I will most definitely be returning.
Stayed 2 nights in Sep 2025

10/10 Excellent

Julie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Sep 2025

10/10 Excellent

Jeffrey

Stayed 2 nights in Aug 2025

10/10 Excellent

Jean-Paul

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in Sep 2025

6/10 Okay

Barrett

Liked: Cleanliness, staff & service
This is a pretty decent hotel that I’ve stayed in many times and enjoyed myself. This time I felt a bit disappointed with the room I was in
Stayed 1 night in Sep 2025

10/10 Excellent

Adam

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 4 nights in Sep 2025

10/10 Excellent

Angela

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Sep 2025

10/10 Excellent

Jeffrey

Liked: Cleanliness, staff & service, property conditions & facilities
I would definitely stay again at this chic hotel chain
Stayed 1 night in Sep 2025

10/10 Excellent

Andrea

Liked: Cleanliness, staff & service, property conditions & facilities
Love my stay at this unique musuem hotel!
Stayed 1 night in Aug 2025

10/10 Excellent

Ellen

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

we'll be back

We love the opportunity to encounter art at every turn. The room was very nice. great location, staff friendly. Bar on premises was cool with a very nice bartender and an amazing bourbon selection of course!
Stayed 1 night in Sep 2025

6/10 Okay

Donna

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Aug 2025

10/10 Excellent

Sachiko, Tell City

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in May 2025

10/10 Excellent

Jae

Stayed 1 night in Aug 2025

8/10 Good

Deron

Liked: Cleanliness, property conditions & facilities
Stayed 1 night in Aug 2025

10/10 Excellent

Robert

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very professional staff throughout the entire building- everyone was courteous and helpful during my stay.
Stayed 1 night in Aug 2025

10/10 Excellent

Patricia

Traveled with family
Liked: Cleanliness, amenities
The staff was great. Rooms were big and immaculate. Food/drinks were great.
Stayed 3 nights in Aug 2025

10/10 Excellent

David

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Aug 2025

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