See all properties

21c Museum Hotel Louisville

4.5 star property
Luxury hotel with a full-service spa, steps from Louisville Slugger Museum

Choose dates to view prices

Photo gallery for 21c Museum Hotel Louisville

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Fountain
Breakfast, lunch and dinner served
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Interior

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Spa
  • Pet friendly
  • Free WiFi

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, 21c Museum Hotel
    ‪1 min walk‬
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, KFC Yum Center
    ‪8 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪10 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(31 reviews)
  • 335 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • City view
  • 435 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(68 reviews)
  • 350 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(34 reviews)
  • City view
  • 455 sq ft
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

  • City view
  • 660 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • City view
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 434 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

10.0 out of 10
Exceptional
(1 review)
  • 435 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

  • City view
  • Sleeps 4
  • 1 Double Bed

You may also like

Ad
Lobby

Hyatt Regency Louisville

Downtown Louisville
  • Pool
  • Free WiFi
  • Restaurant
  • Air conditioning
8.8 out of 10, Excellent, 1,002 reviews
$144 nightly
The price is $169
Feb 26 - Feb 27
Total with taxes and fees
Hyatt Regency Louisville

About the neighborhood

Louisville

Located in Downtown Louisville, 21c Museum Hotel Louisville is adjacent to Louisville Slugger Museum and within a 10-minute walk of other popular attractions like KFC Yum Center. This 91-room, 4.5-star hotel has a restaurant, a full-service spa, and a 24-hour gym.

What's nearby

  • 21c Museum Hotel - 1 min walk - 0.0 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Kentucky International Convention Center - 8 min walk - 0.5 miles
  • KFC Yum Center - 8 min walk - 0.5 miles
  • Whiskey Row - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Jockey Silks Bourbon Bar - ‬7 min walk
  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Swizzle - ‬8 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk

About this property

21c Museum Hotel Louisville

Luxury hotel with a full-service spa, steps from Louisville Slugger Museum
Guests staying at 21c Museum Hotel Louisville enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 32 per night, and there's also limo/town car service. The front desk has multilingual staff on hand 24/7 to help with tours or tickets, dry cleaning/laundry, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include meeting rooms, conference space, and a 24-hour business center.
50-inch LCD TVs come with cable channels, and guests can stay connected with free WiFi and wired Internet. Beds are dressed in premium bedding and down comforters, and bathrooms offer hair dryers and designer toiletries. IPod docks, minibars, and espresso makers are also standard.
Recreational amenities at the hotel include a 24-hour fitness center.

The recreational activities listed below are available either on site or nearby; fees may apply.

21c Spa has 2 treatment rooms. Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. The spa is equipped with a sauna and a steam room. The spa is open daily.

Similar properties

4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham
  • Pool
  • Spa
  • Pet friendly
  • Free WiFi
9.0 out of 10, Wonderful, 4,087 reviews
$160 nightly
The price is $188
Feb 18 - Feb 19
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham

Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Full breakfast available for a fee 7:00 AM to 10:00 AM on weekdays and 8:00 AM to 1:00 PM on weekends; USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance

Business services

  • 24-hour business center
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • Deep-tissue massages
  • Hot stone massages
  • In-room massages
  • Prenatal massages
  • Sauna
  • Spa open daily
  • Sports massages
  • Steam room
  • Swedish massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • At least 80% lighting from LEDs
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • Built in 2006
  • Comprehensive food waste policy
  • Double-glazed windows
  • Eco-friendly cleaning products used
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed
  • Vegan dining options

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Food and drink

  • Champagne service
  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 40.00 per accommodation, per stay
  • Pet weight must not exceed 50 lbs per pet
  • Food and water bowls are available
  • Service animals exempt from fees

Children and extra beds

  • Rollaway/extra beds are available for USD 30.0 per night
  • Free cribs/infant beds are available

Property payment types

Important information

Fees

  • Service fee: USD 5.00 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
This property uses eco-friendly cleaning products
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)
  • Check-in: 4 PM
  • Check-out: 11 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply), along with a car charging station.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A credit card for incidental charges and a government-issued photo ID may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • The credit card used at check-in for incidentals must be in the name of the primary guest who made the reservation.
  • This property uses eco-friendly cleaning products.
  • Onsite safety features include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards.
  • This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
21c Museum Louisville Mgallery
21c Museum Louisville
21c Museum Hotel Louisville Hotel
21c Museum Hotel Louisville MGallery
21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

Is a free cancellation option available at 21c Museum Hotel Louisville?

21c Museum Hotel Louisville provides free cancellation on certain room rates. For more details, review the cancellation policy on our site.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Feb 17, 2026, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Feb 18, 2026 start from $179.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What is there to do near 21c Museum Hotel Louisville?

This hotel is situated in Downtown Louisville, just steps from Louisville Slugger Museum, and within a 10-minute walk of KFC Yum Center and Whiskey Row. You'll also find Ohio River Valley and 21c Museum Hotel less than a mile away.

Will I be able to park at 21c Museum Hotel Louisville?

Yes, valet parking is offered for USD 32 per night with in/out privileges. Accessible parking and electric car charging are also available for guests.

Is there a spa at 21c Museum Hotel Louisville?

21c Spa is the hotel's full-service spa and services include deep-tissue massages.

Does 21c Museum Hotel Louisville have a casino at the property?

No, 21c Museum Hotel Louisville doesn't have a casino.

Will I find an indoor pool at 21c Museum Hotel Louisville?

No, there is no indoor pool at this hotel.

Is 21c Museum Hotel Louisville good for couples?

At this boutique hotel, couples will welcome the many amenities including Champagne service and in-room massages along with a bar.

Does 21c Museum Hotel Louisville have a hot tub?

No, but this hotel does have a steam room.

Does 21c Museum Hotel Louisville have a restaurant that serves breakfast?

Yes, 21c Museum Hotel Louisville serves a full breakfast for a surcharge each morning at Proof on Main.

Will 21c Museum Hotel Louisville allow pets to stay free of charge?

Although they can't stay for free, pets are welcome at 21c Museum Hotel Louisville for a fee of USD 40.00 per accommodation, per stay. The property also provides food and water bowls.

Are there connecting rooms at 21c Museum Hotel Louisville?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

How far is the airport from 21c Museum Hotel Louisville?

The closest major airport to 21c Museum Hotel Louisville is Louisville Intl. Airport (SDF), which is 7.1 mi away (10 minutes by car). Another top airport is Louisville, KY (LOU-Bowman Field), which is located 8.1 mi away (11-minute drive).

Can I book a room with a balcony at 21c Museum Hotel Louisville?

Yes, some guestrooms at 21c Museum Hotel Louisville offer a furnished balcony and may feature city views.

21c Museum Hotel Louisville Reviews

Reviews

9.4

Exceptional

Rating 10 - Excellent. 770 out of 1006 reviews
Rating 8 - Good. 134 out of 1006 reviews
Rating 6 - Okay. 62 out of 1006 reviews
Rating 4 - Poor. 22 out of 1006 reviews
Rating 2 - Terrible. 18 out of 1006 reviews

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

Reviews

10/10 Excellent

Clark and Margaret

Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Room clean , comfortable and quiet.
Stayed 1 night in Nov 2025

10/10 Excellent

Keith

Stayed 1 night in Nov 2025

6/10 Okay

Dwight

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The room was nice and our balcony great but we paid an upgrade fee for the balcony and got an early morning (Sunday) stampede of door slamming from housekeeping who’s entrance was DIRECTLY across from our room (unbeknownst to us). Then, at 9AM, they’re knocking on our door to cleaning when checkout was at 11am. 👎😡 Whatt!? I complained to front desk at checkout but was told there was nothing they could do. I’ve stayed at many 5 star hotels around the world and this was NOT 5 star service or thinking. Ruined our stay.
Stayed 1 night in Nov 2025

10/10 Excellent

Jan Elliott

Traveled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent in every way. The art museum was an added bonus!!!
Stayed 3 nights in Nov 2025

10/10 Excellent

Glenn

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Room comfortable and clean. Staff very helpful and friendly. Loved the art!
Stayed 1 night in Nov 2025

10/10 Excellent

david

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Beautiful environment Helpful friendly staff
Stayed 1 night in Nov 2025

8/10 Good

ABBEY

Traveled with family
Liked: Cleanliness
Bed was comfortable, room was large, bathroom was OK. Staff was kind. Wish the breakfast opened earlier on Sunday.
Stayed 3 nights in Oct 2025

10/10 Excellent

Matthew

Stayed 2 nights in Oct 2025

10/10 Excellent

John

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Oct 2025

10/10 Excellent

Robin, Safety Harbor

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21c Museum Hotel is a fun and unique experience. Beautiful rooms and centrally located to shops, restaurants and distilleries in Louisville.
Stayed 2 nights in Oct 2025

8/10 Good

Richard

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Breakfast had a good variety but in some cases a little over cooked. Right on whiskey row, plenty of dining options
Stayed 3 nights in Oct 2025

10/10 Excellent

Steven

Stayed 2 nights in Oct 2025

10/10 Excellent

Erica

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved our stay, would definitely plan to come back if we are ever in the area again.
Stayed 1 night in Oct 2025

10/10 Excellent

Melissa

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We've wanted to stay at a 21c Museum hotel. We love the concept. And the room was large and well appointed. Staff was A+. We highly recommend when visiting Louisville.
Stayed 1 night in Oct 2025

8/10 Good

Thomas

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Front desk and valets were great. But our room wasn't serviced, which makes the stay less comfortable.
Stayed 2 nights in Oct 2025

10/10 Excellent

Savannah

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Oct 2025

10/10 Excellent

Natalie

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 3 nights in Oct 2025

10/10 Excellent

Stephanie

Traveled with group
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Loved the strange art. I thought the building maintained the character I was expecting by the name and the reviews. Gym was actually better than the reviews.
Stayed 2 nights in Oct 2025

10/10 Excellent

earl

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Perfect location for walking Louisville
Stayed 4 nights in Oct 2025

8/10 Good

Pamela

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Nice art
Stayed 1 night in Oct 2025

6/10 Okay

Kevin

Stayed 3 nights in Oct 2025

10/10 Excellent

Shelley

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We only stayed 1 night, but everything was excellent
Stayed 1 night in Oct 2025

10/10 Excellent

Courtney

Liked: Cleanliness
Stayed 1 night in Sep 2025

8/10 Good

mirtha

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Good location
Stayed 2 nights in Oct 2025

10/10 Excellent

Ralph

Stayed 1 night in Sep 2025

Hotels

Flights

Activities