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21c Museum Hotel Louisville

4.5 star property
Luxury hotel with a full-service spa and a 24-hour fitness center

Choose dates to view prices

Photo gallery for 21c Museum Hotel Louisville

Front of property
Fountain
Interior
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe
Bar (on property)

Reviews

9.2 out of 10
Wonderful

Popular amenities

  • Spa
  • Room service
  • Pet friendly

Explore the area

View in a map
700 W Main Street, Louisville, KY, 40202
  • Place, Louisville Slugger Museum
    ‪3 min walk‬
  • Place, Kentucky International Convention Center
    ‪8 min walk‬
  • Place, KFC Yum Center
    ‪8 min walk‬
  • Airport, Louisville, KY (SDF-Louisville Intl.)
    ‪11 min drive‬

Room options

View all photos for Deluxe Double Room, 2 Double Beds

Deluxe Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Deluxe Double Room, 2 Double Beds

9.6 out of 10
Exceptional
(29 reviews)
  • 335 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Luxury Double Room, 2 Double Beds

Luxury Double Room, 2 Double Beds | Premium bedding, down comforters, minibar, in-room safe

Luxury Double Room, 2 Double Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 435 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed

9.6 out of 10
Exceptional
(65 reviews)
  • 350 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Luxury Room, 1 King Bed

Luxury Room, 1 King Bed | Premium bedding, down comforters, minibar, in-room safe

Luxury Room, 1 King Bed

9.0 out of 10
Wonderful
(32 reviews)
  • 455 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite, Corner

Suite, Corner | Premium bedding, down comforters, minibar, in-room safe

Suite, Corner

  • 660 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room (Asleep in the Cyclone)

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Room (Asleep in the Cyclone)

  • 500 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Suite (Atrium)

Suite (Atrium) | Premium bedding, down comforters, minibar, in-room safe

Suite (Atrium)

  • 580 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Room, Balcony

Room, Balcony | Premium bedding, down comforters, minibar, in-room safe

Room, Balcony

10.0 out of 10
Exceptional
(1 review)
  • 315 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Double Room, Accessible

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

9.0 out of 10
Wonderful
(2 reviews)
  • 455 sq ft
  • Sleeps 4
  • 2 Double Beds

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 434 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

  • 435 sq ft
  • Sleeps 3
  • 1 King Bed

View all photos for Apartment, 1 Double Bed (Rooftop)

Apartment, 1 Double Bed (Rooftop) | Premium bedding, down comforters, minibar, in-room safe

Apartment, 1 Double Bed (Rooftop)

  • Sleeps 4
  • 1 Double Bed

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Exterior

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About the neighborhood

Louisville

Located in Downtown Louisville, 21c Museum Hotel Louisville is next to popular attractions like Ohio River Valley and Louisville Slugger Museum. This 91-room, 4.5-star hotel has a restaurant, a full-service spa, and a 24-hour gym.

What's nearby

  • Muhammad Ali Center - 3 min walk - 0.2 miles
  • Louisville Slugger Museum - 3 min walk - 0.2 miles
  • Fourth Street Live! - 8 min walk - 0.4 miles
  • Kentucky International Convention Center - 8 min walk - 0.5 miles
  • KFC Yum Center - 8 min walk - 0.5 miles

Getting around

  • Louisville Intl. Airport (SDF) - 10 min drive

Restaurants

  • ‪Heine Brothers' Coffee - ‬3 min walk
  • ‪Vincenzo's Italian Restaurant - ‬5 min walk
  • ‪Mussel & Burger Bar - ‬1 min walk
  • ‪Sunergos Coffee and Espresso Bar - ‬6 min walk
  • ‪Pokehana - ‬5 min walk

About this property

21c Museum Hotel Louisville

Luxury hotel with a full-service spa and a 24-hour fitness center
Guests staying at 21c Museum Hotel Louisville enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 32 per night, and there's also limo/town car service. The front desk has multilingual staff on hand 24/7 to help with dry cleaning/laundry, tours or tickets, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include meeting rooms, conference space, and a 24-hour business center.
50-inch LCD TVs come with cable channels, and guests can stay connected with free WiFi and wired Internet. Beds are dressed in premium bedding and down comforters, and bathrooms offer hair dryers and designer toiletries. IPod docks, minibars, and espresso makers are also standard. Change of towels is available on request.
Recreational amenities at the hotel include a 24-hour fitness center.

The recreational activities listed below are available either on site or nearby; fees may apply.

Guests can pamper themselves with a trip to the onsite spa, which has 2 treatment rooms. Services include massages.

Awards and affiliations

Eco-Certified Property
This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Electric car charging station on site
  • Limo/town car service
  • Valet parking on site (USD 32 per night; includes in/out privileges)
  • Wheelchair-accessible parking available

Food and drink

  • Daily full breakfast available for a fee: USD 5 to 25 per person
  • A bar/lounge
  • A restaurant
  • Coffee and tea in common areas

Restaurants on site

  • Proof on Main

Things to do

  • 24-hour gym
  • Full-service spa
  • Yoga classes

Family friendly

  • In-room crib
  • Laundry facilities
  • Rollaway/extra bed (surcharge)
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Free newspapers in lobby
  • Gift shop/newsstand
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Multilingual staff
  • Porter/bellhop
  • Tour and ticket assistance
  • Turndown service

Business services

  • 24-hour business center
  • 5,000 square feet of conference space
  • Computer station
  • Meeting rooms

Full-service spa

  • 2 treatment rooms
  • In-room massages

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Elevator
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible registration desk

More

  • 1 building
  • 4 floors
  • At least 80% lighting from LEDs
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • Built in 2006
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Blackout drapes
  • Down comforter
  • Free crib
  • Hypo-allergenic bedding
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathrobes
  • Designer toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 50-inch LCD TV with premium cable channels
  • iPod dock

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service
  • Minibar

More

  • Air conditioning (climate-controlled)
  • Cleaning products are eco-friendly
  • Connecting rooms available
  • Desk
  • Eco-friendly toiletries
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Soundproofed rooms
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4 PM; Check-in end time: midnight
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

  • This property welcomes pets for USD 40.00 per accommodation, per stay
  • Pet weight must not exceed 50 lbs per pet
  • Food and water bowls are available
  • Service animals exempt from fees

Children and extra beds

  • Rollaway/extra beds are available for USD 30.0 per night
  • Free cribs/infant beds are available

Property payment types

Important information

Fees

  • Service fee: USD 5.00 per accommodation, per stay

These are all of the charges provided to us by the property.

Optional extras

These fees and deposits will be charged at check-in, check-out, or the time of service.

  • Fee for full breakfast: approximately USD 5 to 25 per person
  • Valet parking fee: USD 32 per night (in/out privileges)
  • Pet fee: USD 40.00 per accommodation, per stay
  • Service animals are exempt from fees
  • Rollaway bed fee: USD 30.0 per night

This list may not be comprehensive. Fees and deposits might not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards
This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels)
  • Check-in: 4 PM
  • Check-out: 11 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers valet parking (fees apply), along with a car charging station.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A credit card for incidental charges and a government-issued photo ID may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • The credit card used at check-in for incidentals must be in the name of the primary guest who made the reservation.
  • Onsite safety features include a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards.
  • This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

Additional information about polices, regulations, and more:

  • Reservations need to be made in advance for massage services. Contact the hotel at the phone number listed on your booking confirmation.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

21c Hotel Louisville
21c Hotel Museum
21c Louisville Hotel
21c Museum
21c Museum Hotel
21c Museum Hotel Louisville
21c Museum Louisville
Louisville 21c Hotel
Louisville 21c Museum
Museum Hotel 21c
21c Museum Hotel Louisville MGallery
21c Museum Louisville MGallery
Hotel 21c Museum Hotel Louisville - MGallery Louisville
Louisville 21c Museum Hotel Louisville - MGallery Hotel
21c Museum Hotel Louisville - MGallery Louisville
Hotel 21c Museum Hotel Louisville - MGallery
21c Museum Hotel MGallery
21c Museum MGallery
21c Museum Hotel Louisville
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21c Museum Hotel Louisville Louisville
21c Museum Hotel Louisville Hotel Louisville

Frequently asked questions

Is a free cancellation option available at 21c Museum Hotel Louisville?

21c Museum Hotel Louisville provides free cancellation on certain room rates. For more details, review the cancellation policy on our site.

How much does it cost to stay at 21c Museum Hotel Louisville?

As of Nov 5, 2025, prices found for a 1-night stay for 2 adults at 21c Museum Hotel Louisville on Nov 20, 2025 start from $161.1, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What is there to do near 21c Museum Hotel Louisville?

This hotel is situated in Downtown Louisville, just steps from Ohio River Valley and Louisville Slugger Museum, and within a short walk of KFC Yum Center. You'll also find Fourth Street Live! and Whiskey Row less than a mile away.

Is parking available on site at 21c Museum Hotel Louisville?

Yes, valet parking is offered for USD 32 per night with in/out privileges. Accessible parking and electric car charging are also available for guests.

Is there a spa at 21c Museum Hotel Louisville?

There is a full-service spa available for guests to enjoy and services include massages.

Does 21c Museum Hotel Louisville have a casino at the property?

No, 21c Museum Hotel Louisville doesn't have a casino.

Will I find an indoor pool at 21c Museum Hotel Louisville?

No, there is no indoor pool at this hotel.

What do couples enjoy most about 21c Museum Hotel Louisville?

This boutique hotel offers many amenities for couples, including in-room massages as well as a bar and a restaurant.

Does 21c Museum Hotel Louisville have a hot tub?

No, there isn't a spa tub at this hotel.

Does 21c Museum Hotel Louisville have a restaurant that serves breakfast?

Yes, 21c Museum Hotel Louisville serves a full breakfast for a surcharge each morning at Proof on Main.

Will 21c Museum Hotel Louisville allow pets to stay free of charge?

Although they can't stay for free, pets are welcome at 21c Museum Hotel Louisville for a fee of USD 40.00 per accommodation, per stay. The property also provides food and water bowls.

Are there connecting rooms at 21c Museum Hotel Louisville?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

How far is the airport from 21c Museum Hotel Louisville?

The closest major airport to 21c Museum Hotel Louisville is Louisville Intl. Airport (SDF), which is 7.1 mi away (10 minutes by car). Another top airport is Louisville, KY (LOU-Bowman Field), which is located 8.1 mi away (11-minute drive).

Are there rooms with balconies at 21c Museum Hotel Louisville?

Yes, some guestrooms at 21c Museum Hotel Louisville offer a furnished balcony.

Reviews

21c Museum Hotel Louisville Reviews

9.2

Wonderful

9.6/10

Cleanliness

9.4/10

Staff & service

9.0/10

Amenities

9.6/10

Property conditions & facilities

9.2/10

Eco-friendliness
Rating 10 - Excellent. 758 out of 1000 reviews
Rating 8 - Good. 138 out of 1000 reviews
Rating 6 - Okay. 61 out of 1000 reviews
Rating 4 - Poor. 23 out of 1000 reviews
Rating 2 - Terrible. 20 out of 1000 reviews

Reviews

8/10 Good

Alison

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 6 nights in Jul 2025

10/10 Excellent

Brian

Liked: Cleanliness, staff & service, property conditions & facilities
Nice
Stayed 1 night in Jul 2025

10/10 Excellent

Charles

Stayed 4 nights in Aug 2025

10/10 Excellent

Edward

Stayed 4 nights in Jul 2025

10/10 Excellent

Kathryn, Columbia

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The art gallery was fun. Parking was rough but I chose to do valet and that took care of it. It was pricey but worth it to not have to battle finding parking in the area. The hotel was beautiful and so fun and unique. Close to everything!
Stayed 1 night in Jul 2025

10/10 Excellent

Daniel M

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Centrally located in downtown. Steps to the Ali Center and Louisville Slugger Museum. Staff was friendly and accommodating.
Stayed 3 nights in Jul 2025

6/10 Okay

Nathan

Stayed 1 night in Jul 2025

10/10 Excellent

judith

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Unexpected

Offbeat elegance with just a touch whimsy we throughly enjoyed the 21C. Room was spacious and comfortable and oh so quiet. We loved roaming the galleries and were entertained by the random Penguins. The restaurant was excellent and the staff in the bar and restaurant were stellar. The location was excellent as well.
Stayed 3 nights in Jul 2025

8/10 Good

Verified traveler

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Fun hotel to stay at. I wanted a relaxing stay and that's what I got. TV in room kept freezing up so I ended up watching things from my laptop, but otherwise room was perfect for my needs.
Stayed 2 nights in Jul 2025

10/10 Excellent

Sybil

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was great, ver helpful with answering questions about the city. Restaurant had good food and atmosphere. Loved being surrounded by so many wonderful works of art. We would definitely stay again... it's such a vibe.
Stayed 3 nights in Jun 2025

10/10 Excellent

Halyna

Stayed 2 nights in Jul 2025

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Jul 2025

6/10 Okay

Glenda

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 4 nights in Jun 2025

10/10 Excellent

Tom

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location. Great hotel. Great team members.
Stayed 2 nights in Jul 2025

2/10 Terrible

derek

Stayed 1 night in Jul 2025

8/10 Good

Verified traveler

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It isn't for families
Stayed 1 night in Jul 2025

10/10 Excellent

George

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in Jul 2025

10/10 Excellent

Patricia

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
From the time we walked in to this property the staff was amazing! Anya checked us in and was very friendly and gave us some great food recommendations. This property is quiet and clean. The museum/art aspect is a wonderful piece to the hotel. This property is within 2 blocks of the Louisville Slugger and Mohammed Ali Center...super continent! We would absolutely stay here again!
Stayed 2 nights in Jul 2025

10/10 Excellent

Matt

Stayed 1 night in Jul 2025

10/10 Excellent

Monte

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

21c is Amazing

The hotel and the hotel staff were both excellent. We appreciated the friendliness of every staff member we encountered and the aesthetics of the entire hotel. Our room was very clean, comfortable, appealing and so quiet. We were very pleased with our stay.
Stayed 1 night in Jul 2025

10/10 Excellent

Michael, Austin

Was great
Stayed 4 nights in Jun 2025

10/10 Excellent

Britney

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Very cool hotel

Great hotel in the heart of the Bourbon Trail, loved the big rooms, art and the smiling door man.
Stayed 3 nights in Jun 2025

10/10 Excellent

Thomas, Dingley Village

Stayed 2 nights in Jun 2025

4/10 Poor

Valerie

Traveled with partner
Liked: Cleanliness
The walls were paper thin. Made the stay really uncomfortable. This is my second visit to this hotel, and the art this time around was very disappointing. No exciting installations at all. Location is great. Staff was friendly, I was just really under whelmed with the experience. I don't think I'll be back.
Stayed 2 nights in Jun 2025

10/10 Excellent

Megha

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Jun 2025

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